Episode Summary:
Dr. Dean St. Mart returns for an advanced deep-dive into biological age optimization, mitochondrial peptide protocols, and longevity strategies that goes far beyond basic biohacking.
Dean reveals how he and his wife both tested 10 years younger than their chronological age according to glycation markers, then breaks down the critical mistakes most people are making with mitochondrial peptides like SLU-PP-332—including why low doses are actually more effective and how to properly support your system with activated B-vitamins, antioxidants, and strategic bloodwork monitoring.
The conversation covers telomere protection, cellular replication science, why bodybuilders age faster from chronic mTOR activation, and the pharmacology behind effective peptide dosing including first-pass metabolism and receptor occupancy.
TOP TAKEAWAYS:
Biological age can be measured through blood glycation markers
Dean and his wife both tested 10 years younger than their chronological age using GlycanAge testing, which measures how glycated proteins in your bloodstream indicate metabolic efficiency and oxidative stress levels. This provides actionable feedback on whether your optimization strategies are working.
Low-dose mitochondrial peptides are more effective than high doses
The human equivalent dose for SLU-PP-332 from mouse studies is around 400 micrograms per kilogram (roughly 400mg for a 220lb male), but Dean found optimal results at just 400 micrograms total daily. Taking more doesn't mean better results and significantly increases oxidative stress burden, potentially causing more harm than benefit.
Mitochondrial enhancement requires comprehensive antioxidant support
When using peptides like SLU-PP-332 or MOTS-c, you must support your body with activated B-complex vitamins (not regular forms), CoQ10, glutathione, and monitor GGT levels on bloodwork. Elevated GGT above 20 indicates excessive oxidative stress even when other markers appear normal.
Balance between AMPK and mTOR is essential for longevity
Chronic bodybuilding (constant mTOR activation) accelerates cellular aging and replication, while excessive AMPK stimulation from constant fasting and biohacking can lead to muscle loss. The optimal approach involves 3-4 days of anabolic training with 3-4 days of fasting or lower calories for cellular cleanup.
Hybrid training improves health markers without sacrificing muscle
Incorporating high-intensity cardio, functional movements, and varied training planes prevents joint degeneration, improves mitochondrial density, enhances metabolic flexibility, and maintains athleticism while building muscle mass for long-term health and performance.
CHAPTERS:
0:00 Introduction and Podcast Growth
2:08 Biological Age Testing and Glycation
4:41 Aging Processes and Telomere Protection
7:03 Mitochondrial Dysfunction and Disease
14:54 Risk Assessment and Health Optimization Strategy
17:03 SLU Dosing Philosophy and Concerns
28:02 SLU Risk Mitigation and Training Strategies
33:04 Antioxidant Support and GGT Monitoring
42:16 Alternatives to SLU for Mitochondrial Health
48:55 B Vitamins and MOSI Considerations
55:11 Training Periodization and Hybrid Approaches
1:06:04 AMPK vs mTOR Balance for Longevity
1:13:23 Final Thoughts and Where to Find Dean
Connect with Dr. Dean St. Mart:
Instagram: @Dnstm
Supplement Needs: supplementneeds.co.uk (Use code "Dr. Dean" for 10% off)
Education Platform: sneducation.co.uk
This episode is for educational purposes only. Consult with qualified healthcare professionals before implementing any protocols discussed.