Description
Deep dive into the science → Join elite biohackers: https://www.skool.com/ddtmethod**
Ready-to-use protocols & guides → Start optimizing today: https://www.realprimalhuman.com/website
Tom Sheppard breaks down the science of training optimization, peptide protocols, and performance enhancement for the modern biohacker. From hybrid training approaches that build strength and hypertrophy simultaneously to the most effective peptides for recovery and longevity, this episode delivers actionable strategies for maximizing human performance without compromising health.
KEY TAKEAWAYS:
• Why the "superhuman" biohacker needs to master multiple training modalities instead of specializing in just one
• The surprising truth about how slow real strength gains actually are (even for competitive powerlifters)
• Tom's exact framework for fitting power, strength, hypertrophy, and cardio into minimal weekly training time
• The peptide stack that addresses mitochondrial decline, inflammation, and hormone optimization as you age
• Why most people fail with over-the-counter testosterone boosters (and when they actually work)
• The injectable peptide combination that amplifies growth hormone effects without the side effects of higher doses
CHAPTERS:
0:00 Introduction to Tom Sheppard
1:17 Tom's Journey from Biology to Strength Coaching
4:07 The Modern Biohacker's Training Philosophy
9:12 Power Development and Plyometric Training
12:35 The Power Building Zone: 75-85% Training
16:00 Real Progress is Painfully Slow
21:55 Cardiovascular Training Simplified
26:04 Why All Training Methods Work
29:18 Programming for the Busy Professional
36:09 Movement Mastery and Technical Proficiency
43:05 Peptides and Performance Enhancement Fundamentals
47:03 Growth Hormone and Thymic Health
50:04 The Best Healing Peptides Explained
53:54 Where to Find Tom Sheppard
ABOUT TOM SHEPPARD:
Tom Sheppard is a strength and conditioning coach with a biology degree background who specializes in evidence-based training, nutrition, and peptide optimization. With over 16 years of coaching experience, he works with Elite FTS and co-hosts their Table Talk podcast. Tom combines scientific research with practical application to help athletes and biohackers achieve optimal performance through hybrid training approaches and strategic peptide protocols.
EPISODE RESOURCES:
Tom Sheppard's Social Media:
Instagram: https://www.instagram.com/tom_kaizen
Instagram (Train Kaizen): https://www.instagram.com/train_kaizen
Tom's Platforms:
Elite FTS YouTube: https://www.youtube.com/@EliteFTS
Train Kaizen Website: https://trainkaizen.com/
Deep dive into the science → Join elite biohackers: https://www.skool.com/ddtmethod
Ready-to-use protocols & guides → Start optimizing today: https://www.realprimalhuman.com/website
Dr. Scott Stevenson breaks down his revolutionary Fortitude Training system, revealing why higher frequency training with autoregulation produces superior hypertrophy results compared to traditional bro splits.
This episode covers advanced training periodization, the science of muscle rounds and cluster sets, intra-workout nutrition strategies, and the surprising power of placebo effects on performance.
Whether you're a competitive bodybuilder or optimizing for longevity, Scott's evidence-based approach to progressive overload across multiple rep ranges will transform how you think about building muscle.
KEY TAKEAWAYS:
• Why training each muscle group 3-4 times per week with adjusted volume outperforms traditional once-weekly splits for most lifters
• The autoregulation strategy that lets you maximize effective reps while avoiding overtraining—without rigid programming
• How muscle rounds (cluster sets) allow you to accumulate more high-quality reps at challenging loads than straight sets
• The metabolic reason intra-workout carbohydrates can preserve performance during high-volume training, especially when dieting
• Why open-label placebos work even when you know you're taking a placebo—and how to leverage this for training performance
• The surprising research showing that mouth-rinsing with sweet substances improves strength output through central nervous system effects
ABOUT DR. SCOTT STEVENSON:
Dr. Scott Stevenson is a former college professor, licensed acupuncturist, and competitive bodybuilder with over 30 years of coaching experience. He's the creator of the Fortitude Training system and author of "Be Your Own Bodybuilding Coach."
Scott has coached numerous competitive bodybuilders including IFBB Pro Dave Henry for 15 years, helping athletes achieve pro cards and stage success worldwide. His evidence-based approach combines exercise science, autoregulation principles, and practical coaching experience.
CHAPTERS:
0:00:00 Introduction to Dr. Scott Stevenson
0:01:47 Scott's Background and Career Journey
0:04:18 What is Fortitude Training?
0:08:02 Higher Frequency Training Principles
0:12:00 Individual Response to Training Volume
0:15:05 Autoregulation and Listening to Your Body
0:19:09 The Three Set Types in Fortitude Training
0:22:50 Why Variety Matters for Hypertrophy
0:25:46 Breaking Down Muscle Rounds (Cluster Sets)
0:32:02 How to Execute a Muscle Round Properly
0:39:57 Adjusting Training Based on Carbohydrate Intake
0:45:32 Intra-Workout Nutrition: Carbs and Protein Timing
0:52:32 The Science of Recovery and Nutrient Timing
For the science nerds → Advanced biohacking research: https://www.skool.com/ddtmethod
For the action-takers → Plug-and-play protocols: https://www.realprimalhuman.com/website
Join us for an in-depth conversation with David Herrera, the Solar Athlete, as we explore advanced training methodologies, circadian biology optimization, and cutting-edge health strategies. Learn how sunlight exposure, cold therapy, leptin management, and sleep architecture can dramatically transform your performance, body composition, and overall health. David breaks down the science behind GLP-1 drugs, light therapy protocols, and how to manipulate your environment for maximum results.
CHAPTERS:
0:00 Introduction and David's Current Training Focus
1:53 Building a Training Foundation for Competition
5:06 Unconventional Training Modalities: Bands and Kbox
9:39 The Role of Eccentric Training in Powerlifting Prep
12:17 Programming for Aesthetic vs Performance Goals
17:19 Diet Structure for Performance and Weight Class Competition
20:08 How Sunlight Affects Nutrient Digestion and Utilization
25:27 Manipulating Cold Exposure for Fat Loss
29:54 Box Breathing and Hypoxic Training Techniques
30:56 Using Heat and Light Therapy in Cold Climates
36:08 The Bell Curve of Red Light Therapy Exposure
39:53 Deuterium Depleted Water and Energy Preservation
42:19 Understanding Leptin: The Master Metabolic Regulator
51:00 Fixing Poor GLP-1 Drug Response with Lifestyle
56:24 Sleep Architecture and Melatonin Optimization
61:02 Green Light Therapy for Hemoglobin and Headaches
63:28 Iron States and Regeneration Through Hypoxia
66:30 PEMF and Frequency Therapy Applications
KEY TAKEAWAYS:
• Why David believes most strength athletes are missing critical rotational training that prevents injury and enhances torso stability
• The surprising way cold exposure can make you leaner in winter while eating more fat than in summer
• How leptin actually works at night and why most people taking GLP-1 drugs are missing the bigger picture
• The exact lighting protocol David uses to optimize melatonin and ensure leptin reaches the hypothalamus correctly
• Why green light exposure can eliminate headaches and stabilize hemoglobin in ways most people don't understand
• The truth about deuterium depleted water and whether cheaper alternatives actually exist
ABOUT DAVID HERRERA:
David Herrera, known as the Solar Athlete, is a powerlifting competitor, coach, and circadian biology expert who specializes in optimizing human performance through environmental manipulation. With decades of elite-level training experience, David integrates quantum biology principles, light therapy, and metabolic optimization to help athletes and health enthusiasts achieve peak performance. He's currently preparing for a powerlifting meet at age 40, aiming to surpass his totals from five years ago.
For the science nerds → Advanced biohacking research: https://www.skool.com/ddtmethodFor the action-takers → Coaching and Direct Support: https://www.realprimalhuman.com/websiteBryan Moskow (The Guerrilla Chemist) and Matt Chrisman break down the latest innovations in peptide science for muscle growth, longevity, and performance optimization. From growth hormone secretagogues to the groundbreaking new modified Follistatin and Klotho, this episode reveals cutting-edge protocols that go beyond traditional anabolics. Learn how to leverage these compounds for hypertrophy, recovery, and anti-aging without the typical side effects.CHAPTERS:0:00:00 Introduction - Meet The Guerrilla Chemist & Matt Chrisman0:02:22 Growth Hormone Peptides for Building Muscle0:04:42 IGF-1 LR3 - Does It Actually Work?0:06:03 Stacking Growth Hormone with Secretagogues0:09:05 PEG-MGF and Mechano Growth Factor Explained0:13:56 Water Retention as a Sign of GH Side Effects0:16:01 Insulin Protocols for Muscle Growth and Performance0:19:52 Retatrutide as a Nutrient Partitioner0:24:22 The New Modified Follistatin - Game Changer0:31:01 Why This Follistatin Doesn't Cause Cardiac Issues0:33:53 Real-World Results - 9 Weeks on Follistatin0:42:53 Training Protocols to Maximize Follistatin0:45:56 Klotho for Longevity and Kidney Health0:53:03 Klotho's Impact on Vascular Health and Performance0:56:56 Recommended Age to Start Klotho and Follistatin1:03:30 What's Coming Next from Bio Longevity Labs1:06:56 Important Administration Notes for FollistatinKEY TAKEAWAYS:• Why the new modified Follistatin has a 19-day half-life and doesn't bind to activin (eliminating cardiac side effects that plagued Big Pharma drugs)• The surprising truth about IGF-1 LR3 and whether it actually binds to receptors or just floats around in your bloodstream• How Matt gained 5 pounds of skeletal muscle in 6 weeks while traveling and eating ad libitum with only Follistatin and TRT• Why Klotho may reverse aging at the cellular level by optimizing kidney function, brain health, and endothelial function• The exact insulin timing protocols top bodybuilders use (4-5 IU pre-workout) without risking hypoglycemia• What growth hormone water retention really signals about insulin resistance and why it's a red flag, not a badge of honor
For the science nerds → Advanced biohacking and PED education: https://www.skool.com/ddtmethod
Big Paul returns for the ultimate deep dive into insulin protocols, blood sugar manipulation, and navigating the current PED landscape. Learn the exact insulin dosing strategies that elite bodybuilders use, why insulin is being misused by 99% of people for physique enhancement, and how to structure carb cycling with rapid-acting insulin for maximum muscle growth without getting fat. Paul breaks down the synergy between growth hormone and insulin, the truth about Nandrolone's age-related side effects, and why the mitochondrial peptide stack is revolutionizing contest prep.
Chapters:
0:00 Introduction: Demystifying Insulin for Bodybuilders
0:25 Paul's Training Break & Recovery from Surgery
2:50 The Half-Truths About Steroid Dosages
6:00 Paul's Diabetic Journey & GLP-1 Experience
12:00 Coming Out of a Cut: When to Introduce Insulin
17:30 The Super Compensation Effect with High Volume Training
20:15 Glut-4 Translocation & Insulin Timing Around Workouts
24:40 Why Lantus (Long-Acting Insulin) Is Misused by Bodybuilders
29:00 Rapid-Acting Insulin: The Superior Choice for Meals
33:00 Growth Hormone & Insulin: Counterregulatory Hormones
38:00 Intra-Workout Nutrition & Glycogen Synthesis
42:40 The Powerlifter to Bodybuilder Transformation
47:00 Navigating the Steroid Shortage: No Primo or Masteron
50:30 Equipoise: The Estrogen-Crashing Compound
53:30 Nandrolone (Deca): Age-Related Side Effects
56:15 The Mitochondrial Stack: GLP-1, MOTS-c & SLU-PP-332
1:00:45 Should You Run Peptides Year-Round?
1:02:25 Being Cautious with New Compounds
1:04:40 Where to Find Paul's Content & Courses
KEY TAKEAWAYS:
• Why using Lantus to mask high fasting glucose is making bodybuilders pre-diabetic
• The exact rapid-acting insulin protocol: dosing at meals 1, 3, and 5 on high carb days to maximize glycogen synthesis
• How growth hormone and insulin work as counterregulatory hormones and why you should never take them together
• Why Nandrolone side effects seem to be age-related and how high estrogen exacerbates progesterone issues
• The mitochondrial peptide stack (GLP-1 + MC + SLU) produced the leanest physiques Paul has ever seen in 62 contest preps
Nerd out on the data: Join advanced discussions: https://www.skool.com/ddtmethodGet the playbook: Practical biohacking starts here: https://www.realprimalhuman.com/websiteJay Campbell returns to break down the ultimate performance enhancement protocols for fat loss, consciousness expansion, and longevity optimization. From GLP-1 peptides and Klotho to melanotan-1's spiritual benefits and the truth about high-dose melatonin, this conversation reveals cutting-edge biohacking strategies that pharma doesn't want you to know. Discover why micro-dosing is the key to sustainable results and how to use peptides as tools for radical health transformation.CHAPTERS:0:00 Introduction to Part 21:23 Melanotan-1 and Expanding Consciousness Through Melanin12:40 Pineal Gland Optimization: 5-MeO-DMT and Heroic Dose Melatonin24:15 Navy SEALs Curing PTSD with Plant Medicine42:10 Why Physical Optimization Unlocks Spiritual Connection48:25 Klotho: The Ultimate Longevity and Sexual Performance Protein1:14:20 Klotho's Power to Regenerate Cardiac and Kidney Tissue1:19:35 The Standard American Diet Causes Neurodegeneration1:31:10 GLP-1 Peptides: Why Pharma Doses Are Destroying People1:44:20 Leptin Sensitivity is the Key to GLP-1 Success1:50:35 Micro-Dosing GLPs: The Studies Prove We're Right2:08:30 Bio Longevity Labs and the Future of BiohackingKEY TAKEAWAYS:• Why melanotan-1 combined with sunlight creates profound meditative states and spiritual connection that most people never experience• The shocking truth about how Frank Barr's melanin research was buried after he was "suicided" in 1971• How heroic doses of melatonin (6-10 grams) combined with pinealon enable astral projection and lucid dreaming• Why Navy SEALs with severe PTSD achieved 100% cure rates using 5-MeO-DMT in ceremony• The real reason Klotho is being called the most important longevity protein ever discovered• Why pharmaceutical GLP-1 starting doses are destroying people's receptors and causing massive side effectsABOUT JAY CAMPBELL:Jay Campbell is a five-time international bestselling author, biohacker, and co-founder of Bio Longevity Labs. He's a globally recognized expert on testosterone optimization, therapeutic peptides, and longevity protocols. Jay specializes in teaching people how to unhook from the sick-care medical system through hormonal optimization, peptide therapy, and bio-regulator compounds. His upcoming book "Metabolic Awakening" reveals the truth about GLP-1 peptides and proper micro-dosing protocols.EPISODE RESOURCES:Jay Campbell's Social Media:Instagram: https://instagram.com/jaycampbell333Twitter/X: https://twitter.com/jaycampbell333Website: https://jaycampbell.comBio Longevity Labs: https://biolongevitylabs.comFree Resources & Books: https://jaycampbell.com/free-info
My team is taking on a limited number of 1-1 clients for 2026 apply here: https://realprimalhuman.com/website
Get nerdy with me and other like minded self-experimenters: https://www.skool.com/ddtmethod
Episode Overview
Jay Campbell returns to the DDT Method Podcast for an in-depth exploration of cutting-edge muscle-building peptides and human optimization protocols. Jay shares unprecedented real-world data from a small group of elite biohackers—including himself, Brian Moscow (the Gorilla Chemist), and others—who have added nearly 10 pounds of pure skeletal muscle in just 8 weeks while remaining relatively lean.
The episode dives deep into dosing strategies, optimal stacking protocols and the specific training methodologies required to maximize results. Beyond muscle building, Jay discusses the regulatory landscape shift coming in 2026 when major pharmaceutical companies will restrict GLP access, the emergence of superior small-molecule alternatives, and how practitioners can legally leverage cutting-edge research compounds.
This conversation serves as essential knowledge for anyone serious about advanced optimization, whether building muscle, burning fat, or pursuing comprehensive longevity and biological age reversal protocols.
Chapters:
0:00 Introduction and Jay Campbell's Return
4:19 Follistatin LGR242 Breakthrough and Results
12:01 Dosing Strategies and Stacking Follistatin
17:22 Future of GLP-1s and Regulatory Changes
26:09 Super Retatrutide and Small Molecule Revolution
36:37 Ultimate Muscle Building Stack Revealed
41:18 Training Methodology for Maximum Growth
48:49 Recovery Modalities and Nutrient Partitioning
56:19 Energy Systems and Periodization Principles
1:05:17 The God Stack for Shredding and Longevity
HEALTH DISCLAIMER:
This podcast is for educational purposes only and does not constitute medical advice. The protocols, compounds, and substances discussed (including peptides, growth hormone, anabolics, and research chemicals) carry significant health risks and legal considerations that vary by jurisdiction.
Listeners should consult qualified healthcare providers before implementing any protocols. The hosts are not medical doctors, and individual results vary based on genetics, training, nutrition, and overall health status. Self-administration of research compounds carries inherent risks. This content is designed for informed adults in jurisdictions where such discussions are legal.
Episode Summary:
Dr. Dean St. Mart returns for an advanced deep-dive into biological age optimization, mitochondrial peptide protocols, and longevity strategies that goes far beyond basic biohacking.
Dean reveals how he and his wife both tested 10 years younger than their chronological age according to glycation markers, then breaks down the critical mistakes most people are making with mitochondrial peptides like SLU-PP-332—including why low doses are actually more effective and how to properly support your system with activated B-vitamins, antioxidants, and strategic bloodwork monitoring.
The conversation covers telomere protection, cellular replication science, why bodybuilders age faster from chronic mTOR activation, and the pharmacology behind effective peptide dosing including first-pass metabolism and receptor occupancy.
TOP TAKEAWAYS:
Biological age can be measured through blood glycation markers
Dean and his wife both tested 10 years younger than their chronological age using GlycanAge testing, which measures how glycated proteins in your bloodstream indicate metabolic efficiency and oxidative stress levels. This provides actionable feedback on whether your optimization strategies are working.
Low-dose mitochondrial peptides are more effective than high doses
The human equivalent dose for SLU-PP-332 from mouse studies is around 400 micrograms per kilogram (roughly 400mg for a 220lb male), but Dean found optimal results at just 400 micrograms total daily. Taking more doesn't mean better results and significantly increases oxidative stress burden, potentially causing more harm than benefit.
Mitochondrial enhancement requires comprehensive antioxidant support
When using peptides like SLU-PP-332 or MOTS-c, you must support your body with activated B-complex vitamins (not regular forms), CoQ10, glutathione, and monitor GGT levels on bloodwork. Elevated GGT above 20 indicates excessive oxidative stress even when other markers appear normal.
Balance between AMPK and mTOR is essential for longevity
Chronic bodybuilding (constant mTOR activation) accelerates cellular aging and replication, while excessive AMPK stimulation from constant fasting and biohacking can lead to muscle loss. The optimal approach involves 3-4 days of anabolic training with 3-4 days of fasting or lower calories for cellular cleanup.
Hybrid training improves health markers without sacrificing muscle
Incorporating high-intensity cardio, functional movements, and varied training planes prevents joint degeneration, improves mitochondrial density, enhances metabolic flexibility, and maintains athleticism while building muscle mass for long-term health and performance.
CHAPTERS:
0:00 Introduction and Podcast Growth
2:08 Biological Age Testing and Glycation
4:41 Aging Processes and Telomere Protection
7:03 Mitochondrial Dysfunction and Disease
14:54 Risk Assessment and Health Optimization Strategy
17:03 SLU Dosing Philosophy and Concerns
28:02 SLU Risk Mitigation and Training Strategies
33:04 Antioxidant Support and GGT Monitoring
42:16 Alternatives to SLU for Mitochondrial Health
48:55 B Vitamins and MOSI Considerations
55:11 Training Periodization and Hybrid Approaches
1:06:04 AMPK vs mTOR Balance for Longevity
1:13:23 Final Thoughts and Where to Find Dean
Connect with Dr. Dean St. Mart:
Instagram: @Dnstm
Supplement Needs: supplementneeds.co.uk (Use code "Dr. Dean" for 10% off)
Education Platform: sneducation.co.uk
This episode is for educational purposes only. Consult with qualified healthcare professionals before implementing any protocols discussed.
Join my Advanced Biohacking Education Group Coaching for Elite Men Looking to Lose Fat and Gain Muscle
EPISODE SUMMARY:
In this power-packed episode, Drew sits down with industry legend Kris Gethin - former Bodybuilding.com executive, champion natural bodybuilder, supplement company founder, and now one of the world's leading peptide and longevity experts.
Kris shares his complete evolution from competitive natural bodybuilding to embracing peptides and biohacking after his mold toxicity diagnosis in 2014. He breaks down exactly why peptides don't violate natural bodybuilding principles (they're signaling molecules, not synthetic hormones), and reveals the specific stacks he uses for different goals.
You'll discover Kris's daily optimization routine including ice baths, red light therapy, hydrogen protocols, PEMF therapy, and his strategic approach to fasting. He explains the critical difference between hermetic and non-hermetic antioxidants, why most athletes are destroying their performance with caffeine, and how to shift from sympathetic to parasympathetic nervous system dominance.
This conversation goes deep on practical protocols you can implement immediately - from his "trifecta reset" using pinealon, thymolin and epitalon, to combating EMF exposure, to the exact supplement stack for a 60-day tour requiring peak mental and physical performance.
TOP TAKEAWAYS:
Why peptides are "signaling molecules" not synthetic overrides like TRT or HGH - they tell your body what it should already be producing
The "wired but tired" syndrome affecting high achievers and the pinealon/epitalon/thymolin reset protocol
Hydrogen therapy creates a "calming but focused state" and enhances cognitive performance better than most nootropics
Creatine combined with guanidino acetic acid provides superior absorption through 4 pathways vs. standard monohydrate
EMF sensitivity is real - proper grounding and Faraday protection dramatically improves HRV and sleep quality
The "Jedi mastery" approach: knowing when to use which biohacks based on daily demands rather than following rigid protocols
CHAPTER BREAKDOWN:00:00 Introduction - Kris Gethin Overview02:37 Meet Kris Gethin - Fitness Industry Legend03:35 Kris's Background and Entry into Fitness06:43 Transition to Endurance and Hybrid Athletics07:37 Discovering Biohacking Through Mold Toxicity08:25 Natural Bodybuilding vs Peptides Discussion10:18 Introduction to Peptides and the Wolverine Stack12:26 Kris's Daily Optimization Routine13:40 CNS Reset and Peptide Protocols16:23 Training Split and Nutrition Approach19:29 Jedi Mastery of Biohacking and Longevity21:41 Pinealon and Epitalon for Longevity25:37 Hydrogen Therapy Benefits and Applications29:19 Antioxidant Strategies and Supplementation33:10 Essential Supplements - Creatine and Vitamin D37:17 Unmatched Supplements and Gut Health39:26 Parasympathetic Nervous System Optimization43:22 Mindful Eating and Performance44:18 Vipassana Silent Retreat Experience47:20 EMF Exposure and Protection Strategies53:45 60-Day Tour Protocol for Mental and Physical Peak55:44 Where to Find Kris GethinCONNECT WITH KRIS GETHIN:Instagram: https://www.instagram.com/krisgethin/Kris' Supplement Company
Join my community of advanced biohackers
PEMF therapy has been misunderstood as solely a pain management tool, but this episode reveals its profound potential as a performance enhancement technology. Andy Smith, founder of Celler8 and host of the PEMF Podcast, shares how pulsed electromagnetic field therapy works at the cellular level to recharge mitochondria, increase ATP production, and enhance every biohack from red light therapy to cold plunges.After surviving a near-fatal infection at age 25, Andy discovered PEMF's healing power and has spent 13 years educating others on this NASA-backed technology. Dive into the science behind frequency therapy, optimal protocols for athletes and biohackers, proper device selection based on intensity versus frequency, and how PEMF creates the cellular environment needed for supplements and peptides to work effectively.
Whether you're an advanced optimizer or managing chronic conditions, this episode demonstrates why PEMF deserves a place in every performance enhancement protocol.
Connect with Andy Smith:Instagram - https://www.instagram.com/andysmith_pemf/Podcast - @ThePEMFPodcastCompany - https://www.newmedltd.co.uk
Work with me!
Real Primal Human - Coaching for Elite Men
Episode Summary:
Brandon Eisenhower (@biohackingu) joins Drew to break down the complete optimization playbook for ambitious entrepreneurs and athletes who want peak performance in every domain.
This isn't about taking one magic peptide - it's about understanding how to stack cognitive enhancers, physical performance compounds, and recovery protocols into a comprehensive system that actually works.
The conversation dives deep into cognitive optimization, comparing long-term brain builders like Dihexa and Cerebrolysin versus short-term stimulant strategies.
Brandon explains his controversial take on dopamine system restoration instead of chasing an "Adderall replacement."
He shares why working through the serotonin system for anxiety is more sustainable than GABA-focused compounds.
Lastly Brandon drops serious knowledge on TRT users missing neurosteroid production from skipping important polypharmacy, explaining the cognitive and sleep benefits most people don't realize they're missing.
This episode delivers actionable protocols you can implement immediately while understanding the "why" behind every compound choice.
TOP TAKEAWAYS:
• Steps to take BEFORE optimizing with compounds
• Short-term and long-term nootropic strategies
• Dopamine system repair vs Adderall chasing
• HCG for cognition
• Mitochondrial optimization strategic layering
Connect with Brandon Eisenhower:
Elite Men's Coaching - https://the.realprimalhuman.com/learn-more-hereJoin the Member's Community! Dosing, Protocols and More - https://www.skool.com/ddtmethodEpisode Summary:Chris Duffin sits down with Drew to share decades of practical peptide experience working with elite Bollywood action stars, high-performing executives, and world-class athletes. As the only human to squat and deadlift 1,000 pounds for reps, Chris brings unique insight into optimizing performance at the highest levels. He reveals why fixing dysfunction comes before optimization, explaining his "house building" analogy for understanding how BPC-157, TB-500, GHK-Cu, and KPV work together to create the proper terrain for cellular signaling.The conversation explores Chris's controversial take on popular peptides - why he prefers CJC-1295 over Tesamorelin, his concerns about MK-677, and the IGF-1 protocols that built his legendary strength. Chris breaks down how blood flow restriction training triggers the same angiogenesis and mitochondrial biogenesis signals as peptides, revealing protocols that combine BFR with AMPK-driving compounds for time-efficient muscle building. Drew and Chris compare notes on their current SS-31 and MOTC stacks, discussing optimal timing and why creating cellular responsiveness matters more than adding another compound.Chris shares his foundation supplement stack including fatty-15, TUDCA, ALCAR, and phosphatidylserine - the raw materials cells need before peptides can work properly. From PEMF mats to red light therapy to shockwave, he explains which recovery modalities actually move the needle and how they stack with peptide protocols. Whether you're healing a Bollywood star's staph infection or helping an executive perform at peak capacity while building muscle, this episode delivers battle-tested protocols you won't find anywhere else.CHAPTERS:0:00 - Introduction2:27 - Background & Journey to Human Optimization12:19 - Starting Point: Fixing Dysfunction Before Optimization16:00 - The "Glow Blend" Protocol: BPC, TB500, GHK & KPV18:08 - Understanding Peptide Signaling20:00 - Power Grid Optimization: PEMF, Shockwave & Red Light Therapy23:11 - Training Modalities: BFR, Flywheel & Metabolic Stress25:31 - Blood Flow Restriction: IPC vs Myorep Methods27:04 - The Missing Link in Modern Training30:31 - Peptides for Mass Gainin36:12 - Stacking Modalities for Stem Cell Proliferation36:25 - Growth Hormone Peptide Overview39:27 - Why Chris Avoids MK-677 & Tesamorelin40:00 - Mitochondrial Optimization: SS-31 & MOTS-C Deep Dive43:08 - Drew's Updated Mitochondria Protocol44:08 - Carbon 60: When & Why to Use Antioxidants47:29 - Five Amino 1MQ & TUDKA: NAD Recycling Over Supplementation49:05 - Essential Supplements: Building Cellular Resilience52:02 - The Foundation: Raw Materials, Training & Cellular Health54:05 - Jedi Mastery: Combining Peptides, Training & Biohacking54:35 - Where to Find Chris Duffin & Closing RemarksConnect with Chris Duffin:Instagram: https://www.instagram.com/mad_scientist_duffinYouTube: https://www.youtube.com/user/kabuki07Website: https://www.chrisduffin.com/Free Education Platform: https://www.skool.com/endless-evolution-8560/aboutPaid Education: https://chrisduffin.myshopify.com/pages/community
Elite Men's Coaching - https://the.realprimalhuman.com/learn-more-hereJoin the Member's Community! Dosing, Protocols and More - https://www.skool.com/ddtmethodDisclaimer:Since this podcast was recorded some information regarding the initial testing on bioglutide was made public and Anthony has released this statement - https://www.skool.com/castore-built-to-adapt-7414/statement-from-anthony-castore-and-alchemiq-on-the-bioglutide-biomed-situation?p=5245589aEpisode Summary:Drew and Anthony are back with part two, and this one's packed with protocols you can actually use. The big topic? Bioglutide - the newest GLP that's orally available and might be the answer to muscle loss concerns everyone's been talking about. It hits four different pathways including IGF-1, which changes the game for recovery and building muscle while staying lean.Anthony walks through exactly how to transition off retatrutide without losing progress, including the math on half-lives and strategic timing. Drew shares his personal plan for coming off after nearly a year of use, stacking bioglutide with MOTC, SS-31, and growth hormone for a recomp phase. This isn't theory - it's what they're actually doing.The conversation shifts to cellular health foundations that most people skip. Anthony breaks down his daily supplement stack and explains why plasmalogens, phosphatidylcholine, and TUDCA matter more than adding another peptide. They cover senolytic protocols using FOXO-4 to clear out damaged cells, strategic NAD optimization with 5-Amino-1MQ and 1-MNA, and why your membranes need repair before anything else works optimally.Whether you're deep into enhancement protocols or just trying to understand how to support what you're already doing, this episode delivers actionable information you won't find anywhere else.TOP TAKEAWAYS:• Bioglutide as a game-changing quad-agonist• Strategic GLP transitioning - Reta to Bioglutide• FOXO-4 senolytic protocol strategic timing• Plasmalogens the essential cellular membrane building blocks • Build your cellular foundation before advanced protocolsCHAPTERS:0:00 - Introduction 2:13 - Introduction to GLP-1 Agonists & Fat Loss2:58 - Understanding Bioglutide: The Quad Agonist Breakthrough10:40 - IGF-1 Modulation: How Bioglutide Differs from Injectable IGF14:27 - Transitioning Strategies to Bioglutide: Drew's Protocol Plan24:07 - Incorporating MOTS-c for Fuel Switching27:02 - Five Amino 1MQ: NAD Optimization & Fat Cell Reduction30:16 - Senolytic Protocols: FOX04 DRI for Cellular Cleanup38:44 - Introduction to Plasmalogens: The Building Blocks of Cell Membranes54:03 - Essential Supplement Stack: The Foundation for Optimization1:04:52 - Where to Find Anthony Castor & AlchemIQ Labs ProductsConnect with Anthony Castor:Anthony Castor's Community & Resources:Castor Built to Adapt - Free Skool Community - https://www.skool.com/castore-built-to-adapt-7414 Instagram: https://www.instagram.com/anthonycastore/?hl=en
DDT Method Experimentation Club - http://bit.ly/3KSdGxn
Real Primal Human (RPH) Coaching Program - http://bit.ly/4nl1W3PIn this advanced peptide discussion, Drew Donaldson sits down with human optimization specialist Anthony Castor to decode the controversial SLU-PP-332 dosing debate. While the internet argues between 100 micrograms and 400+ milligrams, Anthony breaks down the science-backed approach to finding your minimal effective dose. This conversation dives deep into mitochondrial function, explaining why overdosing SLU can cause brain fog, insulin resistance, and long-term health issues despite short-term fat loss results.Anthony reveals why most people don't need massive doses of SLU-PP-332, introducing the concept of mitochondrial optimization through strategic stacking with urolithin A. He explains the electron transport chain, mitochondrial fission and fusion, and why supporting your body's natural cleanup processes (mitophagy) is crucial for sustainable results. Drew shares his personal experience titrating from 100 micrograms to 4 milligrams, discovering that 2mg was his sweet spot when supported with proper substrate availability.The episode announces two major launches: the DDT Method exclusive members group for advanced peptide protocols and detailed PED education, plus Real Primal Human (RPH) coaching program featuring elite trainers specializing in human optimization. This is part one of a two-part series delivering actionable protocols for experienced lifters who've plateaued and want to push their physique and performance to the next level through science-backed enhancement strategies.TOP TAKEAWAYS:• Start with minimal effective dosing • Support mitochondrial health with Urolithin A • High doses can backfire • Individual response varies dramatically • Build a stable foundation first CHAPTERS:0:00 - Introduction & Podcast Overview0:53 - Announcements: DDT Method Exclusive Members Group & Real Primal Human Coaching2:29 - Welcome Back: Deep Dive into Peptides with Anthony Castor3:47 - The SLU Dosing Debate: Finding the Right Amount6:04 - Measuring SLU Effectiveness: Objective & Subjective Markers9:08 - Foundation First: Why Starting Dose Matters11:21 - Understanding Dosing Philosophy & Individual Response15:34 - The Problem with Animal Studies & Human Conversion18:01 - Comparing SLU to Known Compounds: The Clenbuterol Analogy20:31 - The Massive Dosage Discrepancy: Micrograms vs Milligrams23:37 - Potential Risks of High-Dose SLU25:09 - Mitochondrial Function & Organ Impact28:04 - Drew's Personal SLU Experience: Testing Different Doses33:01 - Understanding the Brain Fog Effect38:46 - Breaking Down Energy Creation: The Electron Transport Chain Explained47:22 - The Educator's Responsibility in the Modern PED Era48:28 - Introducing Urolithin A: The Missing Piece50:39 - Mitophagy Explained: Fission, Fusion & Cellular Cleanup56:02 - Why Urolithin A + SLU is the Optimal Combination
Pro bodybuilder Dusty Hanshaw joins the DDT Method podcast to share his journey from average genetics to earning his pro card through relentless dedication and smart training. In this comprehensive discussion, Dusty breaks down his experience with DC training and progressive overload protocols, explaining how he maximized his genetic potential by focusing on what he could control rather than lamenting his structural limitations. The conversation covers critical topics including training intensity versus volume, individualized nutrition approaches, and the importance of health monitoring for enhanced athletes.
Dusty and host Drew also share remarkably similar near-death experiences involving esophageal ruptures from years of forced feeding, offering a candid look at the often-overlooked risks of extreme bodybuilding practices. The discussion explores how these experiences shaped their current approaches to training, nutrition, and life priorities. Dusty emphasizes the importance of mastering fundamental training and nutrition principles before adding advanced protocols like peptides, and explains why different body parts may require completely different training approaches based on individual response and genetics.
TOP TAKEAWAYS:
Connect with Dusty Hanshaw:
Instagram - @dustyhanshaw08
Email - dusty@dustyhanshaw.com
Note: This episode contains important discussions about health risks in bodybuilding. Both host and guest emphasize the critical importance of monitoring health markers and not ignoring warning signs, regardless of competitive goals.
David Weck, inventor of the BOSU ball and pioneer of the rope flow movement, joins the DDT Method podcast for an explosive conversation about the fundamental flaws in modern fitness training. Weck shares his journey from Division 3 football player to movement revolutionary, explaining how chronic back pain led him to discover the stability ball and eventually challenge the entire fitness industry's understanding of core stability and human locomotion.
In this wide-ranging discussion, Weck dismantles the "core stability equals spinal stiffness" narrative that dominated exercise science in the 2000s, revealing how this flawed approach has created an epidemic of non-contact injuries and limited athletic potential. He introduces the concept of "force transmission" as the true foundation of athletic performance, explaining why balance and fluid movement patterns trump raw strength alone. From his work with world champion long drive golfer Justin James to his revolutionary approach to deadlifting, Weck provides practical insights for advanced athletes looking to break through plateaus while maintaining joint health and movement quality.
The conversation covers rope flow origins, the importance of rotational training, the "perfect poise to pounce" single-leg balance position, and Weck's vision for a paradigm shift in human movement understanding. Whether you're a competitive athlete, serious lifter, or movement enthusiast, this episode challenges everything you think you know about training the human body for optimal performance.
TOP TAKEAWAYS:
Connect with David Weck:
Website - weckmethod.com
Instagram - @thedavidweck
X/Twitter - @thedavidweck
Episode Summary:
Performance enhancement specialist Broderick Chavez joins the DDT Method Podcast for an extensive conversation about building effective PED protocols using scientific frameworks rather than cookie-cutter approaches. With nearly 40 years of experience starting as a teenage bodybuilder in the competitive 1980s, progressing through elite powerlifting and strongman, and learning from legends like Dr. Fred Hatfield and Tom Platz, Broderick breaks down his systematic methodology for designing personalized drug courses. This episode covers the critical importance of unified language in enhancement (why "course" beats "cycle"), the steroid family tree classification system (testosterone base, DHT derivatives, and 19-nors), and why growth hormone deserves consideration as foundational infrastructure rather than an advanced addition. Broderick explains how water retention actually builds muscle, why trenbolone's reputation is partially misunderstood through improper context, and the dose-response relationship between body weight and drug selection.
The conversation emphasizes assessment-first methodology, examining training history, past drug responses, body composition, and individual goals before selecting compounds. Broderick challenges common industry myths including the overuse of "optimization," the false distinction between "side effects" and "effects," and assumptions about mandatory on-the-fly adjustments versus strategic pre-planning. He provides practical frameworks for understanding why different drug families (DHT for strength with less water, 19-nors for fullness and volume, testosterone derivatives for broad-spectrum effects) serve different physique needs. This episode delivers actionable insights on strategic compound selection, proper dosing escalation, and the often-overlooked importance of building orthopedic infrastructure through growth hormone before accumulating massive muscle mass and training volume.
TOP TAKEAWAYS:
Connect with Broderick Chavez:
Team Evil GSP Member Site - members.teamevilgsp.com
Instagram - @teamevilgsp
Facebook - Team Evil GSP
Former IFBB Pro Steve Kuclo, who placed 6th at Mr. Olympia and 3rd at Arnold Classic, shares his journey from extreme bodybuilding to functional medicine and longevity optimization. As founder of Upgraded Human Wellness, Steve bridges the gap between performance enhancement and health optimization, revealing advanced protocols for those who want to push limits while maintaining long-term wellness.
Steve discusses the critical importance of comprehensive testing, liver health optimization, and smart enhancement strategies that minimize health risks. He reveals how he reversed hypothyroidism naturally, the truth about testosterone dosing, and why most people use far more compounds than necessary. The conversation covers cutting-edge peptide protocols, omega-3 optimization, estrogen management, and the emerging field of longevity medicine that's revolutionizing how athletes approach performance and health.
This episode provides actionable insights for both competitive athletes and health-conscious individuals seeking to optimize performance while prioritizing long-term wellness through science-based protocols and comprehensive health monitoring.
TOP TAKEAWAYS:
• Less is more with enhancement protocols - most people use 2-3x more testosterone and compounds than necessary for optimal results while creating unnecessary health risks
• Comprehensive testing including liver enzymes, omega-3 index, and genetic testing reveals long-term damage and optimization opportunities that standard blood panels miss
• Liver health is the foundation of all enhancement protocols - NAC and glutathione supplementation can dramatically improve compound metabolism and overall health outcomes
• Estrogen management requires precision - both too high and too low estrogen cause serious issues, with natural compounds like DIM often being more effective than harsh AI protocols
• Recovery peptides like BPC-157 and TB-500 should be cycled strategically rather than used year-round to maintain effectiveness and avoid potential long-term risks
CHAPTERS:
00:00 - Introduction: Bridging Bodybuilding and Longevity
03:01 - From Firefighter to IFBB Pro: Steve's Journey
05:54 - The Information Overload Problem in Health
08:26 - Transitioning from Competition to Optimization
11:28 - Testing and Reversing Bodybuilding Damage
14:34 - Natural Thyroid Recovery Protocol
17:27 - Can You Reverse Enhancement Consequences?
21:20 - Smart Enhancement for Young Athletes
25:48 - Testosterone Dosing: Why Less is More
31:08 - Liver Health and Detoxification Protocols
35:05 - Estrogen Management and AI Dangers
39:03 - Hematocrit Management Strategies
42:15 - Omega-3 Optimization and Testing
48:33 - Peptide Protocols for Performance and Recovery
58:53 - Mitochondrial and Longevity Peptides
01:02:14 - Steve's Current Enhancement Protocol
01:06:05 - Working with Upgraded Human Wellness
Connect with Steve Kuclo:
Instagram - https://www.instagram.com/stevekuclo/
Upgraded Human Wellness - https://www.upgradedhuman.com
Facebook - https://www.facebook.com/stevekuclo/
TikTok - https://www.tiktok.com/@stevekuclo
Join Drew from the DDT Method for a mind-bending conversation with polymath scientist Ian Mitchell, who works across chemistry, biochemistry, quantum physics, and materials science. Ian has collaborated with NASA and discovered breakthrough technologies that are revolutionizing human performance and longevity.
TOP TAKEAWAYS:
EPISODE HIGHLIGHTS:
Ian shares his incredible discovery journey that started with trying to fix arthritis and accidentally stumbled upon what could be immortality. Learn about the Nobel Prize-winning carbon molecule that acts like a "nanoscale adaptogen," providing protection against EMF stress, chemical toxins, and cellular damage while dramatically boosting mitochondrial efficiency.
Discover how Ian engineered water with 20x more oxygen than normal, developed quantum charging technology, and created stem cell activation protocols that have reversed Type 1 diabetes. This isn't science fiction - it's peer-reviewed research with clinical trials backing every claim.
CHAPTER BREAKDOWN:
GUEST COMPANIES & CONTACT:
Ian Mitchell is the founder of Wizard Sciences and works with multiple cutting-edge companies developing the future of human optimization:
Join Drew from the DDT Method as he sits down with IFBB Pro Jason Theobald for a groundbreaking discussion that bridges the gap between bodybuilding and functional health. Jason, owner of Scooby Health and co-owner of Advanced Vitality HRT and NewEthics Formulations, reveals how he revolutionized contest prep with his innovative "Slingshot Method."
TOP TAKEAWAYS:
EPISODE HIGHLIGHTS:
Jason shares his controversial Tampa Pro prep where he ate pizza just 10 weeks out, then used cutting-edge peptides and mitochondrial enhancers to achieve his best stage condition ever. Learn how optimizing cellular health, insulin sensitivity, and inflammation can transform your physique goals while actually improving your biomarkers.
Discover the science behind AMPK vs mTOR pathways, the anti-aging benefits of autophagy-inducing compounds, and why traditional "suffer through your diet" mentality is outdated. Jason explains his systematic approach to combining functional medicine principles with elite-level bodybuilding protocols.
CHAPTER BREAKDOWN:
Connect with Jason:
Jason Theobald is available for consultations and coaching through Scooby Health. His team of 14 functionally-trained coaches specializes in combining bodybuilding prep with health optimization protocols.
Experience the future of bodybuilding where getting shredded actually makes you healthier. Jason's approach proves you don't have to choose between aesthetics and longevity.