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A bacterium found in the gut of frogs has powerful anti-cancer effects.  Researchers at the Japan Advanced Institute of Science and Technology report that the bacterium Ewingella americana, found in gastrointestinal tract of Japanese tree frogs, completely eliminates cancers in mice with few if any side effects. This bacterium was one of 45 initially isolated from frogs, newts, and lizards. After screening, it stood out due to its powerful anticancer effects. 

Using a mouse model of colorectal cancer, studies showed that a single intravenous dose too his bacterium eradicated 100 percent of cancers. This bacterial treatment outperforms chemotherapy and immune checkpoint drugs.

These frog bacteria destroy cancer cells using two mechanisms. First, the bacteria naturally target and multiply inside tumors killing them. Second, these bacteria spark an intense immune response that harnesses T cells, B cells, and their inflammatory cell fellow travelers that help the body destroy any remaining cancer cells.

Even better, these frog bacteria are well tolerated by mice. The clear rapidly from the bloodstream, do not colonize healthy organs, cause only brief inflammation, and create no long-term general toxicity during two months of follow up monitoring.

This exciting therapeutic possibility is still in the early stages of development. Still ahead is much more preclinical research before any clinic trials can begin.  Even so, the concept of using select biologic material from other species to eradicate treatment-resistant human disease could lead to spectacular outcomes….someday soon.

https://medicalxpress.com/news/2025-12-gut-bacteria-amphibians-reptiles-tumor.html

https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2599562

#frogs #cancer #bacteria