Moderator: Caterina Leone (Rome, Italy) Guest: Andrea Truini (Rome, Italy) In this episode, Caterina Leone speaks with Andrea Truini about small fibre neuropathy, a frequently under-recognised condition with a significant impact on patients’ quality of life. They discuss key clinical features, including neuropathic pain and autonomic symptoms, and explain why routine nerve conduction studies are often normal. The conversation highlights the role and limitations of skin biopsy and functional testing, the importance of identifying underlying causes, and practical approaches to diagnosis and management with realistic treatment expectations.

Moderator: Rob Hadden (London, United Kingdom) Guest: Claudia Sommer (Würzburg, Germany) In this episode, Rob Hadden and Claudia Sommer discuss ongoing challenges in treating CIDP. While most patients benefit from current therapies, some remain treatment-refractory, driving the need for innovation. They highlight emerging response definitions, promising FcRn and complement inhibitors, and the importance of individualized care and serum biomarkers for improving patient outcomes. This episode has been supported by an educational grant from Argenx. The programme has not been influenced in any way by its supporter.

Moderator: Yilidz Degirmenci (Istanbul, Türkiye) Guest: Hanneke Hulst (Auckland, New Zealand) In this episode, Yıldız Değirmenci speaks with Hanneke Hulst about cognitive problems in multiple sclerosis, an often invisible but highly disabling aspect of the disease. They discuss how common cognitive impairment is in MS, the domains most frequently affected, particularly information processing speed and memory, and the underlying white and gray matter pathology. The conversation highlights the real-world impact on work, relationships, and quality of life, as well as practical strategies for early detection, screening, and cognitive support in clinical practice.

Moderator: Alfonso Magliacano (Florence, Italy) Guest: Charlène Aubinet (Liege, Belgium) In this episode, Alfonso Magliacano is joined by Charlène Aubinet to examine how language and communication impairments shape the assessment and recovery of patients emerging from coma. They discuss the clinical distinctions between unresponsive wakefulness syndrome and the minimally conscious state, highlighting how aphasia and other comorbidities can obscure signs of awareness and lead to misdiagnosis. Dr. Aubinet outlines emerging tools, from eye-tracking assessments to EEG and fMRI markers, that help detect residual language processing even without behavioral responses. The conversation also explores how early linguistic abilities can serve as prognostic indicators, the practical challenges faced by speech therapists, and the evidence that some language processing may persist even in states of severely impaired consciousness, with important clinical and ethical implications.

Moderator: Justyna Paprocka Guests: Stephan Rüegg, Markus Leitinger In this episode, Justyna Paprocka welcomes Stefan Rüegg and Markus Leitinger to examine how clinicians can approach emergency EEG in suspected non-convulsive status epilepticus (NCSE). They discuss NCSE epidemiology, the importance of continuous EEG, and the use of structured diagnostic frameworks including the Salzburg criteria and the 2HELPS2B score. The conversation highlights practical strategies such as IV anti-seizure medication trials, pitfalls in benzodiazepine use, and the complexities of distinguishing NCSE from encephalopathy. The experts also address EEG interpretation in post-anoxic patients and recommend foundational literature for early-career neurologists.

Moderator: Messud Ashina (Copenhagen, Denmark) Guests: Theodoros Mavridis (Dublin, Ireland), Oxana Grosu (Chișinău, Moldova) In this episode, Messud Ashina is joined by Theodoros Mavridis and Oxana Grosu to discuss the latest advances in pain and headache medicine, as highlighted in the EAN Pain and Headache Panels' Yearbook chapters. The conversation dives into recent breakthroughs in the pathophysiology of pain and headaches, as well as cutting-edge approaches to prevention and treatment. The experts explore how new research is influencing clinical practice, with a focus on the synergies between pain and headache management. They also examine emerging trends, potential future directions, and the impact of these developments on patient care.

Moderator: Theodoros Mavridis (Dublin, Ireland) Guests: Diana Aguiar de Sousa (Lisbon, Portugal), Mira Katan (Basel, Switzerland) Embolic stroke of undetermined source (ESUS) continues to challenge clinicians as its definition and diagnostic approach evolve. In this episode, Theodoros Mavridis is joined by Diana Aguiar de Sousa and Mira Katan. They explore the epidemiological, clinical and mechanistic nuances of ESUS, discuss insights gained from major clinical trials, and examine current therapeutic strategies. The conversation also highlights advances in detecting covert embolic sources, the emerging relevance of atrial myopathy, the role of PFO closure, and the promise of biomarkers in shaping future patient care.

Theodoros Mavridis (Dublin, Ireland) Ana Catarina Fonseca (Lisbon, Portugal) In this episode, Theodoros Mavridis speaks with Ana Catarina Fonseca about the updated European guidelines for acute ischemic stroke. They discuss advances in reperfusion therapy, including extended time windows for thrombolysis using advanced imaging, broader eligibility criteria, and evidence supporting thrombectomy in patients with low ASPECTS scores, mild deficits, and posterior circulation strokes. The conversation also highlights the continued importance of stroke unit care and emerging pre-hospital technologies aimed at speeding diagnosis and improving outcomes.

Moderator: Theodoros Mavridis (Dublin, Ireland) Guest: David Seiffge (Bern, Switzerland) In this episode, Theodoros Mavridis speaks with guest David Seiffge about breakthrough strokes, a challenging condition where ischemic strokes occur despite the use of antithrombotic therapies. They explore the diagnostic process, investigating compliance, and identifying competing etiologies. Prof. Seiffge also discusses potential treatment options, including emerging therapies like Factor 11 inhibitors and left atrial appendage closure, offering insights into ongoing trials aimed at improving patient outcomes.

Moderator: Benedetta Storti (San Donà di Piave, Italy) Guest: Charlotte Cordonnier (Lille, France) Join Benedetta Storti and Charlotte Cordonnier for a discussion on the acute management of intracerebral hemorrhage. Discover the latest European Stroke Organization guidelines, the importance of timely intervention, and the evolving role of reversal agents and surgical approaches in stroke care.

Moderator: Mathilde Leonardi (Milan, Italy) Guests: Sanja Gluscevic (Podgorica, Montenegro), Simone Salemme (Modena, Italy) This episode explores how early-career neurologists can bridge science, policy, and society through advocacy—highlighting real examples of how EAN Brain Health Ambassadors are translating brain health into action both within and beyond clinical practice. Becoming a certified Brain Health Ambassador through the EAN's Advocacy Training programme offers neurologists the chance to advance brain health by gaining the knowledge and practical skills needed to advocate effectively at local, national, and European levels. As part of the training, participants will explore the principles of effective advocacy, develop communication strategies, and learn how to engage with key stakeholders such as policymakers and patient organizations in order to drive positive change.

Moderator: Alice Accorroni (Geneva, Switzerland) Guests: James Teo (London, UK), Giuseppe Jurman (Trento, Italy) In this special episode, Dr Alice Accorroni is joined by Professor James Teo and Professor Giuseppe Jurman to discuss the impact of artificial intelligence in neurology: They analyse the actual improvements provided by its adoption, the factors that are hindering this same adoption, especially in a clinical setting, the potential future landscape clinicians and data scientists will be facing and how neurologists' attitude can be oriented more favourably towards new AI solutions.

Moderator: Raphael Wurm (Vienna, Austria) Guest: Francisco Cardoso (Porto, Portugal) Artificial intelligence - hype or revolution? For this week’s special episode, Dr Raphael Wurm welcomes Prof. Cardoso, a movement disorder expert and busy clinician, to explain why he believes that human interaction and connection will remain the most important part of our profession.

Moderator: Roberta Balestrino (Milan, Italy) Guest: Nathalie Nasr (Poitiers, France) Join us as Dr Roberta Balestrino and Professor Nathalie Nasr takes us on a journey into the brain in space—uncovering the vascular challenges of microgravity, their impact on astronauts, and surprising lessons for our health here on Earth.

Moderator: Oxana Grosu (Chisinau, Moldova) Guest: Rolf-Detlef Treede (Mannheim, Germany) Prof. Treede and Dr. Grosu discuss the new ICD-11 classification of chronic pain, highlighting its significance in recognizing chronic pain as a disease in its own right. The need for this classification, its impact on clinical practice, health policy, and research, as well as the complexities surrounding nociplastic pain are highlighted. The dialogue emphasises the importance of precise coding and documentation in improving patient care and treatment outcomes.

Moderator: Simone Vigneri (Bologna, Italy) Guest: Marshall Devor (Jerusalem, Israel) This episode explores the complex clinical features and neurobiology of phantom limb pain, highlighting key mechanisms such as maladaptive plasticity, ectopic discharges, and cortical reorganization. Prof. Marshall Devor shares expert insights into current challenges and future directions in the management of this uniquely human neuropathic pain condition.

Moderator: Katarina Rukavina (Berlin, Germany) Guest: Keela Herr (Iowa City, USA) How do we recognize and manage pain in people with dementia? In this episode of EAN Cast: Weekly Neurology, Katarina Rukavina hosts Keela Herr and they talk about the impact of pain on people living with dementia, strategies for its assessment and management, and how healthcare professionals can work together with family members and carers to ensure holistic care.

EAN moderator: Anna K. Szewczyk (Lublin, Poland) Guest:Grazia Devigili (Milan, Italy) Anna K. Szewczyk and Grazia Devigili discuss Small fiber neuropathy (SFN), a broad group of conditions affecting small nerve fibers (Aδ or C). SFN is characterized by impaired pain and temperature sensation, as well as autonomic dysfunction. Its diagnosis and treatment are challenging, though recent findings on specific autoantibodies and ion channel polymorphisms offer new perspectives for understanding these forms and developing more targeted therapies.

Moderators and guests: Barbara Tettenborn (Bern, Switzerland) and Roberta Balestrino (Milan, Italy) Barbara Tettenborn and Roberta Balestrino discuss the journey of the EAN e-learning platform, eanCampus. Launched in 2022, the platform has transformed neurology education by aligning with European Training Requirements for Neurology and offering comprehensive content for all levels of experience. Discover how interactive modules, gamification, and a commitment to high-quality, peer-reviewed material have made the eanCampus a vital resource for neurologists worldwide.

Moderator: Tobias Cronberg (Lund, Sweden) Guest: Andrea Rossetti (Lausanne, Switzerland) In this episode, Cronberg speaks with Rossetti about the role of EEG in the neuro ICU, with a focus on prognostication and monitoring in critically ill patients. They explore clinical applications, organizational differences across countries, and the value—and limitations—of continuous EEG, spot EEG, and emerging AI tools.