This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener questions about BMI cutoffs, weight cycling, metabolic adaptation, trauma, GLP-1 differences, and why some people gain weight on ultra-low calories. Dr. Cooper explains what’s really happening inside the metabolic system and why individualized treatment—not dieting—creates sustainable change.

Key Questions Answered

• If my BMI doesn’t “qualify” for GLP-1s, is Naltrexone + Bupropion helpful—and what labs matter first?
• Does being overweight always indicate metabolic dysfunction, and why are U.S. rates so high?
• If diets damage metabolism, what do you do when you’re already 80 pounds overweight?
• How long does it take for leptin and ghrelin to stabilize with mechanical eating?
• How can someone gain weight on 1,200 calories/day?
• After sleeve gastrectomy, how do you eat enough while on a GLP-1?
• Is set point theory real—and how does the melanocortin pathway influence it?
• If obesity runs in my family, will I need meds like Zepbound for life?
• How do trauma and stress alter long-term metabolic health?
• Can GLP-1s offset weight gain from steroids, mood meds, or hormones?
• Why might Ozempic work well while Mounjaro causes weight gain?

Key Takeaways

1. BMI rules don’t reflect metabolic truth.
A mid-20s BMI can still mask significant dysfunction, especially with weight cycling.

2. Weight cycling is metabolically stressful.
Repeated losses/regains increase visceral fat, insulin abnormalities, and cardiovascular risk.

3. Obesity is a multi-hormonal disease.
Most people need pharmacology plus sleep, fueling, and movement—not restrictive dieting.

4. Metabolic adaptation is powerful.
Under-fueling lowers thyroid output, suppresses fat-burning, and slows metabolism dramatically.

5. After bariatric surgery or on GLP-1s, frequency matters.
Frequent, nutrient-dense snacks protect muscle, metabolism, and energy.

6. Set point changes with better signaling.
GLP-1s and related therapies help the brain accurately detect weight and lower the defended level.

7. Genetics often mean lifelong support.
Family patterns of obesity usually indicate long-term need for metabolic medication.

8. Trauma amplifies metabolic risk.
Childhood trauma disrupts IGF-1, sleep, stress hormones, insulin, leptin, and ghrelin.

9. Medications can cause weight gain—GLP-1s can help counteract it.
Steroids, mood meds, hormonal agents, and more can be metabolically unfriendly.

10. “Newer” isn’t always better.
Some people respond poorly to the GIP component in Mounjaro/Zepbound. Individual physiology rules.

Dr. Cooper’s Actionable Tips

• Request deeper evaluation: DEXA, visceral fat, fasting insulin/glucose, leptin, reproductive hormones.
• Stop restrictive dieting permanently—mechanical eating protects metabolic stability.
• Work with a fueling-focused dietitian (often ED-trained).
• Review your medication list for drugs known to cause weight gain.
• Don’t switch GLP-1s or chase higher doses if your current regimen works.

Notable Quote

“Obesity isn’t a willpower problem. It’s a metabolic disease, and when the underlying system is supported, the body finally has permission to change.” — Dr. Emily Cooper

Links & Resources

• Podcast Home: Fat Science Podcast Website
• Submit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
• Dr. Emily Cooper on LinkedIn
• Mark Wright on LinkedIn
• Andrea Taylor on Instagram

Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.

Dr. Emily Cooper, Mark Wright, and Andrea Taylor talk with Maria from Buffalo, a longtime listener who shares her lifelong journey with obesity, psoriatic arthritis, and binge eating—and how finally understanding the science of metabolism gave her hope. Maria describes early childhood weight gain, joint damage, and years of restrictive dieting and food shame, then explains how GLP‑1 therapy (Zepbound) plus mechanical eating helped her lose about 50 pounds while eating more food, more often, and with more joy. 

Dr. Cooper breaks down the underlying biology—leptin, weight set point, the melanocortin pathway, and the impact of pain, sleep, and chronic inflammation on hunger hormones—and reframes obesity as a symptom of deeper metabolic problems, not a character flaw. This episode doubles as a practical, emotionally honest guide for patients trying to navigate a traditional health‑care system without a dedicated metabolic specialist.

Key Questions Answered

• How can rapid childhood weight gain, autoimmune disease, and early joint damage signal serious metabolic dysfunction rather than “too much food” or “not enough exercise”?

• What is leptin, what does “too low for your size” mean, and how does that affect hunger, weight set point, and weight loss?

• What is monogenic obesity testing, who might qualify for free genetic screening, and how can results inform (but not necessarily change) treatment?

• How do GLP‑1 medications like Zepbound work with mechanical eating so someone can lose weight while eating more regularly and with more variety?

• Which labs (fasting glucose, insulin, leptin, etc.) help uncover hidden metabolic issues, and when is a mixed‑meal test more useful than a simple fasting snapshot?

• When should brain‑active medications (such as bupropion/naltrexone combinations) be considered, and what trade‑offs and side effects matter?

• How can patients respectfully push for tests, challenge old “eat less, move more” advice, and set boundaries around weigh‑ins and stigmatizing language?

Key Takeaways

• It’s not your fault: Rapid childhood weight gain and early‑onset obesity often reflect serious metabolic biology, including rare gene variants, growth phases, and hormone signaling—not gluttony or laziness.

• Obesity is a symptom: Excess weight is better understood as a side effect of underlying metabolic fires (leptin issues, insulin resistance, brain signaling problems) that need proper diagnosis and treatment.

• Leptin really matters: Low leptin for your size can act as a biological brake on weight loss, and chronic dieting, under‑fueling, over‑exercise, and some high‑dose supplements can suppress it further.

• GLP‑1s plus mechanical eating: Medications like Zepbound can quiet food noise and support weight loss, but scheduled, balanced eating is essential to avoid under‑fueling, protect muscle, and support hormones.

• Pain and sleep are metabolic: Chronic pain and poor sleep increase hunger hormones like ghrelin and disrupt repair processes, worsening metabolic dysfunction unless directly addressed.

• Script your visits: Bring a printed list of diagnoses, medications, and questions; use patient portals to request specific tests; and practice simple boundary phrases around weighing and diet talk.

Notable Quote
“This isn’t all just caused by diets and things like that. There was an original metabolic problem. It was amplified because of the food restriction and the psychology around it, but you are a product of cumulative insults to your system—not a moral failure.” — Dr. Emily Cooper

Links & Resources

• Podcast Home: https://fatsciencepodcast.com/

• Cooper Center for Metabolism & Fat Science Episodes: https://coopermetabolic.com/podcast/

• Resources and education from Dr. Cooper: https://coopermetabolic.com/resources/

• Submit a Show Question: questions@fatsciencepodcast.com

• Dr. Cooper direct show email: dr.c@fatsciencepodcast.com

Fat Science is informational only and does not constitute medical advice.

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor field your most urgent metabolic health questions—exploring care advocacy, novel drug use, lab results, and how to filter fact from fiction in the TikTok age. 

Dr. Cooper offers clinical clarity, real-world perspective, and actionable hope—with an emphasis on what truly matters for your long-term health and energy.

Hear from listeners experiencing real breakthroughs (and challenges) with GLP-1s, get tips for navigating confusing cholesterol results, and learn why self-advocacy and good science matter more than credentials or hype. This is not a quick-fix episode; it’s real metabolic medicine, mythbusting, and grounded encouragement for your health journey.

Key Questions Answered

• What labs and scores best assess your true metabolic risk—and how do you make sense of fasting glucose, glucose-insulin ratio (GIR), and FIB-4?
• How can you find a medical provider who’ll actually give you the time and attention metabolic care requires?
• Why do GLP-1s benefit more than weight loss alone? Listeners report help with sleep apnea, inflammation, and food noise—what does the science say?
• How should you reintroduce carbs after restriction, and what’s the safest way to monitor (beyond A1C)?
• What’s up with rising cholesterol on Zepbound, and when do you worry?
• Does serotonin syndrome relate to GLP-1s? (Short answer: No—Dr. Cooper explains why.)
• What are the dangers of “GLP-1 microdosing” as pushed by social media, and what happens when influencers overstep good science?

Key Takeaways

• Care that cares: The best doctor isn’t always the most credentialed—find someone, MD, NP, or PA, who takes your questions seriously and goes deeper than the surface. 
• Labs that matter: Fasting glucose, insulin, GIR, HbA1c, plus advanced lipid testing (CardioIQ, NMR) are critical for uncovering hidden risk—not just chasing numbers. 
• GLP-1s act broadly: Listeners see gains in sleep, inflammation, and appetite regulation. These benefits are real, not just anecdotal, and Dr. Cooper shares the clinical rationale. 
• Smart fueling, even on GLP-1s: If you lack hunger cues, “mechanical eating” prevents under-fueling and cellular stress—especially important for maintaining muscle and metabolism. 
• Rethinking “microdosing”: TikTok trends are not medical advice—microdosing with black-market GLP-1s is unproven, poorly regulated, and potentially unsafe. Rely on trusted, legal medication sources only. 

Dr. Cooper’s Actionable Tips

• Request a full panel for metabolic health: ask your provider about fasting insulin, GIR, HbA1c, lipids, and FIB-4—even if you haven’t been flagged as “at risk”. 
• For those on GLP-1s: Don’t skip meals; create a schedule with protein and fiber to avoid muscle loss and ensure micronutrient intake. 
• Experiencing cholesterol shifts on medication? Ask for a breakdown (HDL, LDL, particle size) and consider advanced panels (CardioIQ, NMR) to better understand your risk. 
• If reintroducing carbs after restriction, pair them with protein or fat and test glucose/insulin at intervals post-meal to personalize your plan. 
• Avoid unregulated “microdosing” and buy only from reputable, FDA-approved outlets—protect your long-term health over quick fixes. 

Notable Quote

“The most important thing is somebody who cares, not necessarily their degrees.”— Dr. Emily Cooper

Links & Resources

Podcast Home: Fat Science Podcast WebsiteSubmit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram
Advanced cholesterol testing: CardioIQ at Quest, NMR at LabCorpFat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice. 

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor dive into your burning questions from around the world—exploring misunderstood metabolic problems, hard-won solutions for real people, and the science behind the headlines. From “selfish brain” physiology to the rollercoaster of insurance and medication access, Dr. Cooper brings clinical clarity and practical hope.

Hear real-world listener stories, get advice on tuning your metabolic health, and learn why personalization—not “calories in, calories out”—leads to better outcomes. This is no silver bullet show: it’s metabolic medicine, mythbusting, and science-backed encouragement for your journey.

Key Questions Answered

• What is the “selfish brain” and how does it really impact blood sugar and diabetes risk?
• Why do GLP-1 medications affect stamina and hunger, and how should you fuel your body if you’re using them?
• If insurance pulls coverage for medications like Ozempic or Zepbound, what are your practical, safe, and affordable options?
• How do metabolic markers, medication “cocktails,” and genetic testing shape Dr. Cooper’s individualized care—and can you taper off meds and maintain results?
• What does “normal” blood sugar look like after meals, and how do you distinguish trends from outliers?

Key Takeaways

• Metabolism is complex—individualized care is essential. Diabetes, hypoglycemia, and insulin resistance all have personal causes and require testing like the Mixed Meal Tolerance Test to solve—not one-size-fits-all advice. 
• GLP-1s require smart fueling. Many experience reduced stamina on these medications. Dr. Cooper recommends upping both complex and simple carbs pre-exercise and consulting with a registered dietitian if fatigue persists. 
• Insurance coverage is a challenge—but not the end. Generic options (like liraglutide/Victoza via Mark Cuban Cost Plus Drugs), manufacturer programs, and “cocktail” regimens can support continued progress, even if you lose access to top-brand GLP-1s. 
• Feedback loops & genetics drive lasting outcomes. While some patients can successfully—slowly—taper medications, most with metabolic dysfunction will need long-term support. “Clean eating” alone rarely reverses underlying feedback loop glitches. 
• Monitoring is powerful. Using blood sugar monitors (especially for diabetics) can demystify meal spikes and help fine-tune nutrition and medication timing. 
• Personal stories reflect broader truths. Listeners share struggles and solutions, reinforcing that metabolic health spans medication, motivation, and mindset.

Dr. Cooper’s Actionable Tips

• Always dig deeper with testing—not just A1C but also post-meal spikes via the Mixed Meal Tolerance Test.
• If you’re prescribed a GLP-1 and struggle with energy, increase carb intake safely and talk to a doctor about medication adjustment. 
• For lost coverage, stick to FDA-approved sources: Lilly Direct for Zepbound, Novocare for Wegovy, and Mark Cuban for generics. Don’t risk unregulated online compounds. 
• Recognize the difference between generalized “healthy” habits and targeted strategies that actually move your biomarkers.
• Stay consistent and compassionate—focus on small improvements over extremes and absolutes.

Notable Quote

“The metabolism is regulated by a feedback loop…when you introduce outside hormone forms, you strengthen signals to favor fuel utilization over energy conservation.”— Dr. Emily Cooper

Links & Resources

• Podcast Home: Fat Science Podcast Website
• Submit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
• Dr. Emily Cooper on LinkedIn
• Mark Wright on LinkedIn
• Andrea Taylor on Instagram
• Generic medication access: Mark Cuban Cost Plus Drugs
• Zepbound direct: Lilly Direct
• Additional info: Novocare for Wegovy

Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor take a trip to the past when Dr. Cooper didn’t have many supporters in medicine. She shares what it was like to be ridiculed by her peers, why she refused to give up on her patients, and how her science-based approach to metabolism was finally validated by mainstream medicine.

Hear the raw, unfiltered story of resilience, patient advocacy, and scientific discovery that led Dr. Cooper from being dismissed as “voodoo” to blazing a trail for real metabolic health.

Key Questions Answered:

• Why did so many in the medical community reject Dr. Cooper’s methods—like challenging “calories in, calories out”—when she started treating metabolic issues?
• What does the rise of GLP-1 medications reveal about the true science behind appetite, metabolism, and weight?
• How did Dr. Cooper hold onto her integrity and keep practicing effective, patient-centered medicine despite overwhelming opposition?
• When does medical “common sense” get replaced by real science, and what does that mean for anyone struggling with diets that fail?

Key Takeaways:

• Progress means facing skepticism. Dr. Cooper was once called a "voodoo doctor" and even yelled at by other physicians for her scientific methods, but results spoke louder than her critics. 
• Metabolism is personal and complex—restrictive diets and “eat less, move more” advice often backfire. Hormonal science and careful patient tracking revealed why old rules failed. 
• Persistent curiosity and data-driven practice, not popularity, eventually shift the culture. Dr. Cooper leaned on a “matrix” of metabolic markers long before these tests were commonplace. 
• GLP-1 medications (like Byetta and Victoza) have moved from obscure tools to mainstream, validating Dr. Cooper’s approach to treating the whole metabolic system. 
• True healing means fueling, not restricting. “Eating more,” not less, was key to metabolic recovery for many patients—a radical, often ridiculed idea that’s now supported by science and real-world clinical data from thousands of patients.
• Patient stories mirror the medical journey—today, both patients and providers can look back and realize that “voodoo” was simply science ahead of its time. 

Dr. Cooper’s Actionable Tips:

• Question easy answers—when in doubt, follow the data, not tradition.
• Find a provider who listens, tests, and adapts treatment to you—not just your weight or a number on a scale.
• Remember that real science can be lonely before it’s mainstream. Trust progress, even when it feels slow.
• Celebrate freedom from food guilt; focus on nourishment, steady energy, and self-compassion, not dieting extremes.

Notable Quote:

“It does make you feel lonely because you feel like there’s no one to talk to, but it was always about doing right by the science and by my patients.” — Dr. Emily Cooper

Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only, not medical advice.

Check out our website to submit a question, explore resources, or reach our hosts.

Have questions for Dr. Cooper, a show idea, or feedback?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram

his week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor tackle the biggest listener questions about sustainable weight loss, metabolic health, and why restrictive diets so often backfire. From medications like GLP-1s to common myths about exercise and nutrition, this episode delivers practical science and down-to-earth advice for anyone struggling with their weight and/or health.

Dr. Cooper breaks down why obesity is a physical sign of underlying metabolic dysfunction and sets the record straight about what really works for long-term health—spoiler: it’s not endless calorie counting or exercise alone. Listeners from around the world share their struggles and triumphs, and Dr. Cooper explains the roles of genetics, “food noise,” dealing with hypoglycemia, and the best ways to fuel your body.

Key Questions Answered:

• Can someone with obesity achieve lasting weight loss without medication? Why don’t diets and exercise alone work long-term?
• What is reactive hypoglycemia after gastric bypass, and how should it be managed?
• How can people with limited access to healthcare still improve metabolic health?
• What is “food noise,” and how do new medications target the brain’s hunger and satiety signals?
• Should people use calorie restriction or focus on fueling their bodies for better metabolic health?

Key Takeaways:

• Obesity is best understood as a physical sign of metabolic disease, not a personal failure.
• There is no diet or exercise program shown to sustain long-term weight loss for those with obesity—medical therapies are usually necessary. 
• Caloric restriction and exercise without medical intervention can slow metabolism and drive weight regain (the “diet backlash” effect). 
• Good metabolic health is possible at any body size. Nutrition, physical activity, sleep, and stress management are essential but cannot, by themselves, reverse obesity.
• Medications like GLP-1s can help “quiet” food noise by restoring healthy communication between the gut and brain.
• Lifestyle strategies support metabolic function but aren’t strong enough to reverse metabolic disease alone. Focus on eating regular meals, balanced nutrients, and fueling your activity—not on perfection or restriction.

Dr. Cooper’s Actionable Tips:

• Find a clinician who listens and is curious about your health, not just weight or calorie intake.
• Don’t be pressured to take medication if you feel healthy and have good lab results, regardless of your weight.
• Fuel your body consistently with a mix of protein, healthy fats, and complex carbs—perfection isn’t necessary.
• Prioritize sleep and stress management, as both are critical for metabolism.

Notable Quote:"There is no diet or exercise program that leads to long-term weight loss in someone with obesity. There isn't. Any time you're introducing that restriction you're opening the door to what's called metabolic adaptation, a slowing of the metabolic system. Why would you want to do that? If your whole goal is to strengthen the metabolic system, why would we want to introduce something that's been proven scientifically to slow the metabolic system down?" — Dr. Emily Cooper

Resources from the episode:Fat Science is your source for understanding why metabolic health—not weight alone—matters more than ever. No diets, no agendas, just science that makes you feel better. This show is informational only, not medical advice.

Check out our website to submit a question to the listener mailbag.

Have questions for Dr. Cooper, a show idea, feedback, or just want to connect?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor dive into the latest U.S. blood pressure guidelines—and reveal why nearly half of all Americans face risks that can no longer be ignored. Early intervention and smart lifestyle changes are at the heart of these new recommendations.

Why is high blood pressure such a hidden danger? What do the new “elevated” and “stage one” categories mean for real people? How do doctors decide when it’s time for medication versus lifestyle changes? And how does blood pressure connect to kidneys, strokes, and even dementia? Dr. Cooper unpacks the science, gives practical advice, and shares why home monitoring is now a crucial part of medical care.

In this conversation-dense episode, the team breaks old myths and empowers listeners to take charge—so that “keeping an eye” on blood pressure becomes active prevention, not passive worry.

Key Takeaways:

• New guidelines lower the bar for concern—120 over 80 is now “caution,” and 130 over 80 is “hypertension.” Early action matters.
• Untreated high blood pressure can lead to irreversible organ damage, strokes, kidney disease, and cognitive decline.
• Doctors now have a better toolkit: updated cutoffs, risk “calculators” that include zip code, and clearer protocols for who needs medication right away.
• Lifestyle changes (fruit, vegetables, less sodium, more movement, quality sleep, stress management, and alcohol moderation) are the first line for many—especially in the “elevated” category.
• Metabolic syndrome often includes high blood pressure; medicines like GLP-1s and metformin may help regulate pressure as well as metabolism.
• Accurate home blood pressure monitoring is strongly recommended, with validated cuff meters (not wrist models).

Dr. Cooper shares actionable tips:

• Eat five servings of fruits and vegetables daily for potassium—bananas, spinach, potatoes, kiwis all help.
• Get a “validated” cuff monitor and check morning/evening, resting, following best practices.
• Ask your doctor about the new guidelines and risk calculators (found at the American Heart Association website).

Notable Quote:

“Home readings are very valuable. I really encourage people to look at the Validate BP site, find a good meter, and keep a log. Catching high blood pressure early and treating it aggressively can have profound impacts on your future health.”— Dr. Emily Cooper

Resources from the episode:

Fat Science is your source for understanding why blood pressure—and metabolic health—matter more than ever. No diets, no agendas, just science that makes you feel better.This show is informational only, not medical advice.

Check out our website to submit a question to the listener mailbag.Have questions for Dr. Cooper, a show idea, feedback, or just want to connect?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram

Fat Science Ep 106The Mailbag: GLP 1s, Leptin, Hormones & Insurance AdviceThis week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor open the listener mailbag to answer real questions from around the world about metabolism, hormones, and GLP-1 therapy. From the UK to Seattle, listeners share personal stories of confusion and discovery — and Dr. Cooper brings metabolic science back into focus.What really happens when you stop GLP-1 medications? Why can someone eat less yet gain weight? What does leptin resistance actually mean? And how can hopeful moms safely navigate treatment before pregnancy?In this conversation-rich episode, the team moves beyond myths, helping listeners understand how hormones — not willpower — drive metabolism, appetite, and long-term health.Key Takeaways:• GLP-1 medications don’t “work by starving you” — they help the body use energy better by resetting fuel use hormones.• Restrictive eating and “calories in, calories out” oversimplify metabolism and often worsen hormonal imbalance.• Leptin isn’t just about levels — signaling quality determines how well your brain recognizes stored body fat.• Pregnancy and metabolic health require careful timing; GLP-1s aren't used during pregnancy, but improved metabolic strength before conception matters most.• Rapid weight loss from GLP-1 meds can risk muscle depletion; maintaining steady nutrition and proper dosing is key.• Insurance coverage for GLP 1s remains unpredictable, but persistence and documentation can open doors.Personal Stories & Practical Advice:Andrea and Mark share their own experiences reconciling appetite changes on GLP-1 therapy — from remembering to eat when hunger signals quiet down to finding fueling strategies that work.Dr. Cooper offers practical guidance rooted in clinical data: why ordered eating keeps metabolism stable, how dietitians with eating disorder expertise support GLP-1 patients, and when to adjust medication doses to protect muscle mass.Notable Quote:“It’s not technically the weight that’s messing up fertility — it’s the metabolic dysfunction that causes weight as a symptom.” — Emily Cooper, MD.In this listener mailbag edition of Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor unpack the science behind GLP-1 medications, leptin resistance, and hormone balance. From fertility to appetite changes and insurance frustrations, this episode explains how metabolism—not willpower—drives lasting health. Hear real-world advice on fueling, mechanical eating, and safe GLP-1 use.

Resources from the episode:

Fat Science is a podcast on a mission to explain where our fat really comes from — and why it won’t go (and stay) away. We’re committed to a world where people understand that fat isn’t a failure and metabolism is not a math problem.This show is for informational purposes only and not a substitute for medical advice.

Check out our website where you can ask a mailbag question.

Have a question for Dr. Cooper, a show idea, feedback, or just want to connect?Email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright take on one of the biggest misinformation waves in popular health media: the rise of “microdosed” GLP‑1s and so‑called “GLP‑1 diets.” 

As GLP‑1 medications dominate headlines and social media feeds, the hosts cut through the noise to explain what’s actually safe, what’s marketing hype, and why restrictive diets go against metabolic science. 

Dr. Cooper reveals how calorie‑cutting research became misinterpreted, how compounded microdoses are being promoted like supplements, and why “just eat less” remains one of the most harmful messages for people trying to improve their metabolic health. 

From the hormonal backlash of dieting to potentially-dangerous online telehealth shortcuts, this episode exposes how the new era of “skinny shots” and influencer‑driven microdosing campaigns echo decades of failed diet culture.

Key Takeaways:

• GLP‑1 medications were never meant to be microdosed — these are serious prescription treatments, not vitamin‑like supplements.
• “GLP‑1 diets” persist because clinical trials paired the drugs with low‑calorie plans — but science hasn’t yet proven those restrictions help long‑term.
• Chronic calorie restriction weakens metabolism, disrupts hormones, and sets up “defensive weight gain.”
• Compounded or telehealth‑prescribed GLP‑1 versions are often untested and can be risky; many forms haven’t even been through FDA approval.
• Real progress comes from fueling your metabolism — eating enough, exercising with support, and stabilizing your brain’s hunger signals.

Personal Stories & Practical Advice:Andrea opens up about the challenge of “mechanical eating” on GLP‑1 therapy — remembering to eat even when not hungry — while Mark shares how his own food relationship transformed once he focused on fueling, not restriction. Dr. Cooper emphasizes her 25‑year‑old shift away from calorie‑cutting, showing how patients thrive when metabolism is strengthened, not starved.

Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay) away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question.Have a question for Dr. Cooper, a show idea, feedback, or just want to connect? Email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor are joined by renowned childhood obesity expert Dr. Evan Nadler for a deep, honest conversation about what really is making our kids fat—and what’s finally changing about how kids, parents, and doctors can fight it.

The panel unpacks why the word “fat” is still so emotionally charged, how culture and even healthcare still get it wrong about weight, and why obesity must be recognized as a medical disease—not a moral failure. Dr. Nadler shares stories from two decades on the front lines, Dr. Cooper highlights transformative new science, and Andrea brings personal experience that challenges stereotypes and reveals the harm of shame-based approaches.

From the latest treatments—including medication and surgery for kids under 12—to the power of genetics, hormones, and family history, this episode breaks the silence, busts the myths, and lays out hope for families everywhere.

Key Takeaways:

• The global prevalence of childhood obesity keeps rising, with 15 million kids in the US now affected, and most will progress to adult obesity without intervention.
• Obesity in kids is driven by a complex web of biology—genes, prenatal health, and hormones—not “overeating” or lack of willpower.
• Parental health before and during pregnancy strongly affects a child’s risk of obesity, and interventions work best when started early—even before birth.
• Shame, strict dieting, and constant focus on weight do lifelong damage. Kids need support, not blame, and a focus on total health—sleep, nutrition, stress, and fun movement.
• New medications (like GLP-1 agonists) and bariatric surgery are safe, evidence-based options for select children, and can be life-changing when used correctly.
• Advances in science and patient care show that individualized treatment (not “one-size-fits-all” fixes) leads to the best long-term health and lower risk of serious complications in adulthood.
• There are always choices—kids and families should know they are not alone, and there are always next steps in medical care, whatever age or size a child may be.

Resources from the episode:Fat Science is dedicated to empowering families and changing the conversation about metabolism—reminding us all that fat isn’t a failure. For more resources, stories, and to submit a listener question, visit our website. If you are a healthcare professional and are interested in Dr Cooper’s upcoming training course, click on provider course at the Fat Science Podcast website! 

If you have questions, a show idea, feedback, or want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.

Connect with Dr. Evan Nadler on his website.

*This podcast is for informational purposes only and is not intended to replace professional medical advice.

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take a hard look at the buzz around microdosing metabolic medications—from what “microdosing” actually means to the risks of following trends without clinical supervision. The team unpacks widespread misunderstandings about dosing for drugs like Ozempic, Zepbound, and low-dose naltrexone (LDN), explains why social media advice can be dangerous, and highlights just how unique every person’s metabolic needs are. 

Dr. Cooper shares patient examples and lays out the science behind hormone regulation, medication resistance, and why skipping a full evaluation could backfire. We cover why glandular extracts and testosterone supplements can disrupt your body’s natural balance and why trying to “trick” your metabolism with tiny doses can sometimes do more harm than good.

Key Takeaways:

• Microdosing means doses far below anything supplied by drug companies—it’s not the same as prescribing a lower dose within the normal range.
• Popular trends in LA and beyond push people toward self-experimentation, often with compounded drugs or unsupervised regimens.
• Taking metabolic drugs without a clinical need can weaken natural hormone production and create dependency—even with “natural” supplements.
• GLP-1s, GIPs, naltrexone, and testosterone all show very different outcomes depending on your genetics, history of dieting, childhood athletics, or use of other medications.
• More is not always better. Too high a dose can create medication resistance, while too low might “numb out” your hormone response.
• Professional evaluation, sleep, nutrition, and self-kindness remain the first line of defense for metabolic health, rather than skipping over those and heading straight to medication.

Resources from the episode: Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question. If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

If you are a healthcare professional interested in Dr. Cooper's training course, go to FatSciencePodcast.com and click on the top right button for Provider Course.Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down five eye-opening research studies from 2025 that challenge everything you thought you knew about obesity, dieting, and metabolism. 

The hosts explore surprising new evidence on fitness trackers, the metabolic power of joy (and dessert!), the risks of intermittent fasting, how yo-yo dieting can damage kidney health, and the permanent impact of dieting on your brain-gut connection.

Dr. Cooper shares clinical insights and explains why simple fixes—strict diets, calorie counting, and food restriction—can actually backfire, causing more harm than good. From the science of hormone signaling to the pitfalls of diet culture, the conversation reveals powerful new reasons to embrace flexibility, balance, and self-kindness on the journey to metabolic health.

Key Takeaways:

• Fitness trackers can dramatically underestimate calorie burn—errors can reach 93%, especially for people with higher body weight. Companies rarely test enough real-world diversity and may fudge numbers for marketing.
• Including dessert and “forbidden foods” in your diet leads to better metabolic outcomes, greater mental stability, and less risk of binge eating or weight regain. Joyful eating helps regulate critical hormones like leptin and ghrelin.
• Intermittent fasting is linked to hair loss. Energy deficits force the body to use fatty acids as fuel, which can damage hair follicle stem cells. Long-term fasting negatively disrupts glucose/insulin balance and destabilizes metabolism.
• Yo-yo dieting (weight cycling) now shows a direct connection with kidney damage—even in those at normal weight. Rapid weight shifts restrict kidney blood flow, raise cortisol, and cause irreversible damage.
• Dieting creates lasting changes in the microbiome and brain-gut signaling that promote weight regain and appetite dysregulation. Even a single round of weight cycling can create stubborn metabolic obstacles.

Personal Stories & Practical Advice:Andrea shares why dessert is a staple of her happiness—and how mental restriction backfires. Dr. Cooper gives real-world examples from patients: eating favorite foods can unlock better weight results, while “diet damage” often lingers until medical treatment repairs it. 

Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question. If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.

REFERENCES FOR THIS EPISODEAlshurafa, N., et al. (2025). “More accurate fitness tracking for people with obesity.” *Scientific Reports*, Northwestern University Feinberg School of Medicine.Alfouzan, N.W., & Nakamura, M.T. (2025). “Reduced food cravings correlated with a 24-month period of weight loss and weight maintenance.” *Physiology & Behavior*, Vol. 291.Chen, H., Liu, C., Cui, S., et al. (2025). “Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.” *Cell*, Vol. 188.The Endocrine Society (2025). “Yo-yo dieting may significantly increase kidney disease risk in people with type 1 diabetes.” *Journal of Clinical Endocrinology & Metabolism*, February 2025.Fouesnard, M., et al. (2025). “Weight cycling deregulates eating behavior via the induction of durable gut dysbiosis.” *Advanced Science*, 2025

This week on Fat Science, Mark Wright, Andrea Taylor, and Dr. Emily Cooper dig deep into the science and history behind why diets don’t work for lasting weight management. From early fad diets, through to modern metabolic research, the episode explains why calorie restriction often backfires—and why fueling the body is key to long-term health.

Dr. Cooper unpacks the latest evidence about metabolic adaptation, the hormonal drivers of weight regain, and the persistent harms caused by repeated dieting. Listeners will leave with a renewed understanding of metabolism’s complexity, the importance of medical advocacy, and the critical need to challenge diet culture and weight bias.

Key Takeaways

• Short-term weight loss from dieting is common, but centuries of evidence show most weight is regained—sometimes with additional harm.
• Metabolic adaptation and hormonal changes (like drops in leptin and rises in ghrelin) make weight regain almost inevitable for most people after calorie restriction.
• Repeated dieting (weight cycling) increases the risk of cardiovascular disease and visceral fat, not just regaining lost weight.
• The biggest breakthroughs in metabolism came in the 20th century, but weight bias and diet industry profits keep the focus on ineffective short-term strategies.
• True long-term progress rests on regular fueling, metabolic evaluation, and avoiding the trap of repeated restrictive diets.

Expert Insights & Practical Advice

• Dr. Cooper highlights landmark studies (Minnesota Starvation Experiment, Dutch famine, the "Biggest Loser" follow-up) illustrating how diets slow metabolism and can even cause lasting damage.
• The science behind metabolic hormones—leptin, ghrelin, adiponectin, GLP-1—shows why the body fights back against weight loss and why medications must be paired with metabolic support, not additional restriction.
• Reflections on weight bias in medicine, the need for informed consent around diets, and how current research is still catching up to clinical reality.

Personal Stories & Culture Critique

• Andrea shares how social circles demonstrate the futility of diets and the cycle of weight loss and regain.
• Mark recounts professional experiences highlighting systemic bias and cultural attitudes toward weight and health, advocating for preventive medicine as the path forward.
• The hosts challenge listeners to rethink their relationship with food, prioritize health, and push back against societal shame and stigma.

Resources from the Episode

Fat Science is committed to debunking the myths about metabolism, diabetes, and fat. We empower listeners with evidence-based information, challenging the culture of blame and restriction. This podcast is for informational purposes and not medical advice.

• Explore our website to join our live audience for the milestone 100th episode recording on Thursday, September 4th at 9 a.m. PST—ask Dr. Cooper a question and celebrate with us!
• Send questions, show ideas, or feedback: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
• Connect with Dr. Emily Cooper on [LinkedIn]
• Connect with Mark Wright on [LinkedIn]
• Connect with Andrea Taylor on [Instagram]

Fat Science: No diet, no agenda—just science that makes you feel better.

The 100th episode of Fat Science brings together Dr. Emily Cooper, Andrea Taylor, and Mark Wright for a live mailbag celebration with listeners worldwide. Hear how the show began, reflect on lessons learned, and get answers to the questions people wish their doctors would address—especially about metabolism, obesity, diabetes, GLP-1 medications, and more.

Dr. Cooper shares the big-picture science behind “why we get fat,” the true drivers of metabolic dysfunction, and the evolution of her pioneering clinical practice. Andrea and Mark reveal the patient’s perspective—an honest look at what happens when the latest science meets real lives. Plus, practitioners and patients weigh in on the shifting cultural tide: it’s not a diet problem, it’s a metabolic problem.

Key Takeaways:

• GLP-1 medications do not appear to harm future fertility or cause birth defect risks; improved metabolism may even help down the road.
• Leptin resistance/suppression: what labs really mean, why mechanical eating matters, and how ghrelin and other signals clarify the picture.
• “Diet Drug” stigma is outdated; GLP-1 medications target dysfunction, not willpower.
• Compounded GLP-1 solutions can be risky. Dr. Cooper explains supply chain, testing, and safer cost-saving alternatives like Lilly Direct, NovoCare, and Canadian Kwik pens.
• Autoimmune diseases (like celiac) may interfere with signals, but GLP-1s—especially bioidentical ones—are still options with careful monitoring.
• “Selfish Brain” explained: labs to request, what cerebral insulin suppression looks like, and why fueling and sleep are core solutions.
• Hashimoto’s: often distinct from metabolic dysfunction; both need tailored management and mechanical fueling.
• Heavy lifting & nutrition: protein needs often overstated—1.0–1.3g/kg ideal; pre-bed protein useful; DEXA scans help track muscle mass.
• Menopause & metabolism: estrogen/leptin loss, why patch plus micronized progesterone is often safest, and how each choice impacts metabolic health.
• Navigating insurance complexities, tariffs, and lifetime maxes—when and how to explore creative access.
• Metabolic changes tied to cycles, pregnancy, birth control: which progestins are weight-neutral, what to ask, and which labs to run if hitting plateaus.
• GLP-1s often improve blood pressure; dizziness may mean time to reduce meds, not the GLP-1.

Personal Stories & Practical Advice:Andrea and Mark share a decade-plus of metabolic journeys—their dramatic health wins and the ongoing battle for self-compassion and body image. Listeners celebrate victories: reversing fatty liver, thriving after cancer, and breaking free from diet cycles.

“No diets. No agendas. Just science that makes you feel better.” The audience and hosts repeat this Fat Science tagline to mark the milestone.

Resources:Fat Science explains where fat really comes from and why it won’t just go away. We’re committed to empowering people with accurate information about metabolism and busting the myth that fat is failure. This podcast is informational only and not medical advice.

Check out our new website to ask a mailbag question. Contact us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the dangers of under-fueling and challenge dieting myths with guest Gina Davito. This episode dives into Gina’s journey from extreme restriction and over-exercising to finally achieving metabolic balance and freedom from food obsession. 

Dr. Cooper sheds light on the science behind metabolic adaptation, appetite regulation, and why fueling your body—rather than restricting—is essential for long-term health. Listeners will come away with a new perspective on weight management, the power of metabolic healing, and a celebration of food as a source of nourishment and joy.

Key Takeaways:

• Chronic dieting and excessive exercise can trigger severe metabolic adaptation and worsen weight gain, creating a cycle that is hard to break without proper medical support.
• Abnormal hunger and weight gain are symptoms of underlying metabolic dysfunction, not lack of willpower—often exacerbated by early and repeated dieting.
• True progress involves nourishing the body and trusting medical guidance, sometimes including tailored medications to reset metabolic balance.
• Mental freedom from food-related anxiety arrives with metabolic healing—allowing for joy in eating and exercise for health rather than punishment.
• Early interventions for kids showing unusual hunger or weight patterns should focus on metabolic evaluation, not restriction.

Personal Stories & Practical Advice:

• Gina describes her transformation from compulsive restriction to vibrant health and athleticism—no longer trapped by thoughts of food or weight.
• Andrea and Mark share their relief at experiencing food freedom and highlight the importance of enjoying both food and movement.

Resources from the episode:

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

This week on Fat Science we answer your questions in another, always-popular mailbag episode. Join Mark Wright, Andrea Taylor, and Dr. Emily Cooper and learn why some people don’t respond to GLP-1 medications, get the latest on new, oral weight-loss drugs, and explore the science behind elevated liver enzymes. 

Dr. Cooper offers practical insights backed by metabolic research. She also addresses gluten-free diets, flavored seltzers, craving pathways in the brain, chronic pain management, and the importance of consistent eating patterns for metabolic health.

Key Takeaways:

• About 20% of people may not respond to GLP-1s due to genetic and metabolic differences; deeper lab and genetic testing may be needed to uncover root causes.
• New oral GLP-1 options like Orforglipron are on the horizon, promising greater convenience and accessibility.
• Transient increases in liver enzymes can occur with rapid weight changes; regular monitoring and medical guidance are important.
• The POMC pathway in the brain plays a crucial role in cravings and metabolism—medications like Contrave can help by targeting this pathway.
• Flavored seltzers are generally fine, but watch for BPA-lined cans; gluten-free isn’t always healthier unless medically necessary.
• Chronic pain medications often impact metabolism—exploring underlying metabolic causes and non-GABA, non-opioid alternatives with providers is key.
• Consistent, “patterned” eating supports metabolic stability and brain function.

Personal Stories & Practical Advice:

• Andrea shares how tweaking her medication “cocktail” and eating patterns improved her results.
• Dr. Cooper and Mark discuss real-life snack strategies for fueling brain power and avoiding metabolic pitfalls.

Resources from the episode:

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they dive into the power of strength training—not just for elite athletes, but for everyday health and longevity.

This week’s guests bring unique perspectives: Faith Ireland, retired Washington State Supreme Court Justice and 82-year-old world-record-holding powerlifter, and Russell Cunningham, MA, CRC, exercise physiologist who specializes in rehabilitation, human performance, and the science of aging strong.

Faith shares her inspirational journey from recovering after a car accident to competing internationally with 15 world records. Russell explains the hard science behind why muscle strength and power are linked to bone density, fall prevention, metabolism, and even brain health. Dr. Cooper adds the medical lens, showing why strength training is essential for long-term vitality.

Key Takeaways:

• Strength training preserves lean mass, protects bone health, and improves functionality at any age.
• Research shows if you can’t leg press at least 50% of your body weight, your fall risk skyrockets; strength training dramatically reduces that risk—even into your 90s.
• Power, not just strength, is key: the ability to move quickly and explosively helps prevent falls and injuries.
• Strength training improves more than muscles—it benefits insulin resistance, metabolic health, and brain function, with emerging links to dementia prevention.
• Starting safely matters: Small steps, proper form, and gradual adaptation are essential to build a foundation and avoid injuries.
• Even 10 minutes of lifting or bodyweight movement can build health when done consistently.

Personal Stories & Practical Advice:

• Faith explains how returning to lifting after back injury and hip replacements gave her confidence and resilience, even through cancer treatments.
• Andrea admits she’s been putting off strength training and asks Faith for advice on how best to get started.
• Russell shares insights from research showing why explosive strength matters for both older adults and younger people alike.
• Dr. Cooper explains the risks of “too much too soon,” highlights foundational training phases, and describes how nutrition and hormonal health affect results.
• Mark gets candid about how yoga and even golfing without a cart reminded him how fitness translates into everyday life.

Resources from the episode:

• Faith Ireland’s memoir: Getting to Justice: From Unwed Mother to State Supreme Court
• Dr. Emily Cooper’s book: The Metabolic Storm (2nd edition; new edition forthcoming)

Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.

Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram

Check out our new website where you can submit a mailbag question and sign up for our upcoming 100th Episode live audience taping on Thursday, September 4th at 9 a.m. PST! Be part of the milestone and bring your questions for Dr. Cooper.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us atquestions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Fat Science is supported by the non-profit Diabesity Institute, working to expand access to effective, science-based metabolic care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unravel the complex role of cortisol, the body’s primary stress hormone. 

Dr. Cooper explains how cortisol isn’t always bad—it helps us adapt to stress, mobilize energy, and even save our lives in emergencies, but chronic elevation can cause serious health problems like insomnia, weight gain, and increased risk for diabetes and heart disease. 

The team explores the science behind how stress impacts metabolism, why recovery and adaptation are essential, and practical, science-backed strategies for managing stress in everyday life.

Key Takeaways:

• Cortisol helps the body adapt to acute stress but becomes harmful when chronically elevated, increasing risk for major health issues including metabolic dysfunction.
• Chronic stress can impair sleep, disrupt blood sugar regulation, and suppress immune function.
• Managing stress involves more than just eliminating stressors—recovery, lifestyle shifts, and purposeful micro-breaks are vital for a healthy stress response.
• Meditation, certain types of yoga, gentle exercise, fueling workouts with carbs, and improving sleep all have proven benefits for regulating cortisol.
• Balancing lifestyle choices, nourishing the body with complex carbs, antioxidants, and gut-friendly foods, and setting boundaries are crucial for long-term metabolic health.

Personal Stories & Practical Advice:

• Andrea opens up about stress shopping and learning healthier coping habits.
• Mark shares how his career-induced sleep deprivation affected his health, and the positive changes he’s made.
• Dr. Cooper offers actionable advice on finding realistic ways to “take the load off,” from better sleep to more intentional rest.

Resources from the episode:

Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories. 

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the surprising influence of parental perception on children’s weight and metabolic health. Dr. Cooper breaks down the science connecting how parents think and talk about body size to the way their kids develop physically and emotionally. The episode tackles the real-world consequences of parental concerns, dieting mindsets, and body image on children’s metabolism, offering insights into creating supportive environments for healthy growth.

Key Takeaways:

• Parental focus on weight—even with good intentions—can inadvertently lead to increased weight and metabolic dysfunction in children, regardless of their starting size.
• Kids’ brains are attuned to perceptions of scarcity or restriction, which may trigger a slowed metabolism and greater long-term weight gain.
• Positive, open communication and listening to children’s cues around hunger and satisfaction are crucial for healthy development.
• Early restrictive interventions, like dieting or food policing, can increase risk for disordered eating, poor self-esteem, and metabolic issues.
• Healthcare providers and parents should prioritize metabolic health over weight-centric approaches, leaving space for normal growth patterns and individual differences.

Personal Stories & Practical Advice:

• Andrea shares her childhood experiences with parental dieting, restriction, and its lasting emotional effects.
• Dr. Cooper outlines practical steps for parents: trust your child’s hunger cues, ensure regular nutritious meals, avoid body shaming language, and seek medical advice privately if concerned about weight.
• Mark emphasizes how society’s focus on body size can harm both kids and adults, reinforcing the need for compassion and science-driven solutions.

Resources from the episode:

Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories. 

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, you can now reach us at Fat Science’s new website: https://fatsciencepodcast.com, or email us at questions@fatsciencepodcast.com, or dr.C@fatsciencepodcast.com. 

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright open the Fat Science mailbag to answer listener questions from around the globe. 

This episode covers real-world metabolic challenges—from navigating calorie restriction and GLP-1 medications to the complexities of bariatric surgery, prednisone’s impact on weight, and menopause. 

Dr. Cooper offers clear explanations and practical advice for healthcare professionals and patients alike on understanding metabolic dysfunction, interpreting lab results, and setting realistic weight loss expectations.

Key Takeaways:

• Calorie restriction and intermittent fasting can destabilize metabolism, making recovery complex for some patients—gradual changes and medical monitoring are essential.
• Bariatric surgery can be an effective intervention for those with significant insulin resistance or high hunger signals. Pre-surgery metabolic testing (like insulin, glucose, and ghrelin levels) is valuable in assessing the likely benefit.
• Plateaus after surgery, persistent weight struggles, and the role of genetics highlight the need for root-cause investigation, not just symptom management.
• Prednisone and hormone therapies (including MHT for menopause) can affect metabolic health; small dietary adjustments, body composition testing, and tailored exercise are crucial for optimizing outcomes.
• Guidance on GLP-1 medication maintenance: Most patients benefit from staying on weight loss meds long-term, but dose adjustment is possible when side effects arise. Stability over many months is critical before considering any taper.

Personal Stories & Practical Advice:

• Andrea shares her experience with bariatric surgery and ongoing metabolic management, emphasizing realistic expectations and the benefit of medication-surgery synergy.
• Listeners ask: how to evaluate readiness to stop weight loss meds, address side effects, and balance hormone needs during menopause.

Resources from the episode:

Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.

• Updates on Dr. Cooper’s upcoming virtual metabolic health training—ideal for practitioners in the UK and beyond.
• Information about Melanocortin pathway testing programs for severe, persistent obesity.https://uncoveringrareobesity.com/
• Link to previous show. “GLP-1s: Will I Have to Take Them Forever?” (5/19/25)https://open.spotify.com/episode/1GZA71gTMSz0idbnEYblVO?si=gJXxNkbYTHykhNDw0Ebltg 
• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/