Is a "normal" mammogram result enough to truly protect your health? What if your standard scan is missing crucial information that could predict your risk for both breast cancer and heart disease years in advance? This episode challenges the one-size-fits-all approach to medical imaging and explores the future of AI in radiology for personalized patient care. We uncover how machine learning is moving healthcare from a reactive model to a proactive one, where diseases are caught earlier and treatments are tailored to the individual, not the average.
In this installment of our Physician Innovators series, host Dr. Trevor Royce sits down with Dr. Sean Raj, a practicing radiologist and the Chief Innovation Officer and Chief Medical Officer at SimonMed Imaging. Dr. Raj breaks down how his team is pioneering this shift at one of the largest outpatient imaging practices in the nation. We dive deep into SimonMed's groundbreaking programs, which are redefining what patients can learn from a single imaging session. Dr. Raj explains the revolutionary "Mammogram Plus" program, which provides a highly personalized breast cancer screening by analyzing not just the image, but a patient's individual risk factors like breast density to provide actionable insights. We also explore the incredible innovation of detecting heart disease from mammograms—a capability that leverages the same scan to identify early signs of breast arterial calcifications, giving women a powerful two-for-one look at their health. The conversation also turns to the rising trend of proactive health screening with the whole body MRI for early detection. Dr. Raj details SimonMed's "simonONE" program, which utilizes advanced 3-Tesla MRI machines and AI to conduct comprehensive scans in as little as 30 minutes, finding silent diseases years before symptoms might appear. Throughout the discussion, Dr. Raj emphasizes the benefits of AI in medical imaging, from enhancing radiologist performance to making advanced diagnostics more affordable and accessible. This episode is a must-watch for anyone interested in the future of medicine, technology, and for aspiring physician innovators in health tech looking to make a scalable impact on patient outcomes.
About Our Guest:
Dr. Sean Raj is the Chief Innovation Officer at SimonMed Imaging. A practicing radiologist who completed his breast imaging fellowship at Harvard Medical School's Beth Israel Deaconess Medical Center, Dr. Raj is dedicated to integrating cutting-edge technology into clinical practice. He leads SimonMed's initiatives in evaluating and implementing new technologies like artificial intelligence, developing patient-centered research programs, and making proactive healthcare accessible and affordable on a national scale.
Timestamps:
(00:00) Introduction to Physician Innovators & Dr. Sean Raj
(02:20) Dr. Raj's Journey: From Medicine to Health Tech Innovation
(06:12) Mammogram Plus: Using AI for Personalized Breast and Heart Health
(11:02) Measuring Success: Patient Outcomes, Experience, and Scalability
(12:01) The Radiologist's Experience: Integrating AI into the Clinical Workflow
(15:52) Proactive Health Screening with the simonONE Whole Body MRI
(19:19) Balancing Innovation, Affordability, and Patient Access
(21:10) Enhancing Patient Understanding with Digital, Digestible Reports
(25:32) The Future of Radiology: Towards Proactive and Hyper-Personalized Care
(27:22) Advice for Aspiring Physician Innovators
Learn More From Our Guest / Episode Resources:
How does a successful academic cardiologist leave a prestigious career to build a pioneering virtual mental health company from the ground up? This episode unpacks the incredible physician transition to health tech with Dr. Reena Pande, a cardiologist turned innovator who scaled a startup to a major acquisition and is now shaping the future of clinician executive leadership. If you've ever wondered how to leverage your clinical expertise beyond the bedside and make an impact at scale, this conversation is for you.
In this deep dive, Dr. Reena Pande shares the untold story of her journey from a grant-funded researcher and faculty member at Harvard Medical School to becoming the first Chief Medical Officer at AbleTo. She details the "ferocious curiosity" that led her to explore the world of health tech and venture capital, driven by a desire to address patient needs more holistically, particularly in the intersection of physical and mental health. Dr. Pande explains the challenges and triumphs of scaling a virtual mental health company, detailing how AbleTo grew from a 10-person team with a $1.5M Series A to a thousand-person organization acquired by Optum. She provides a candid look at the Chief Medical Officer role in tech, emphasizing the need to blend clinical and business acumen, roll up your sleeves, and grow as a leader as the company evolves.
This discussion offers invaluable advice for physicians in health tech, covering the pitfalls to avoid—such as acting like the sole expert—and the mindset required to succeed, including humility and a willingness to learn the language of business (from EBITDA to COGS). Dr. Pande also recounts the dramatic impact of the pandemic, which she describes as "pouring gasoline" on the simmering need for virtual care, and how AbleTo's rigorous, quality-first approach enabled them to meet the explosive demand. Now a Partner at Oxeon leading their clinician executive search practice, she shares insights on what the industry needs most from physician leaders today and her vision for training the next generation of clinicians in the age of AI. This episode is a masterclass in clinician executive leadership and a must-listen for any doctor considering a physician transition to health tech.
About Our Guest:
Dr. Reena Pande is a Partner at Oxeon, where she leads the clinician executive search practice. Before joining Oxeon, she spent nearly a decade as the Chief Medical Officer of AbleTo (now Optum Behavioral Care), a pioneer in virtual mental healthcare. At AbleTo, she led the company’s product, data, and research efforts, scaling the organization through its acquisition by Optum. Dr. Pande was previously an academic cardiologist at Brigham and Women's Hospital and a faculty member at Harvard Medical School. She is a passionate advocate for integrating technology with empathetic, human-centered care to transform health outcomes.
Timestamps / Chapters:
(00:00) Introduction to Dr. Reena Pande
(01:23) Dr. Pande's Origin Story: The Path to Medicine and Cardiology
(05:16) The Leap: Pivoting from Academic Medicine to Health Tech Innovation
(09:43) Building AbleTo: A Pioneer in Virtual Mental Healthcare
(12:04) The Chief Medical Officer Role: Scaling a Health Tech Company
(13:57) How the Pandemic Became a Catalyst for Virtual Mental Health
(19:13) From CMO to Matchmaker: A New Chapter at Oxeon
(23:16) Common Pitfalls for Physicians Transitioning to Tech Roles
(28:43) "Know Thyself": Key Advice for Aspiring Physician Innovators
(30:39) Forecasting the Future: AI and the Next Generation of Clinicians
Learn More From Our Guest / Episode Resources:
What if the millions of hours of video captured during medical procedures weren't thrown away? A revolution in AI in endoscopy is underway, turning this once-wasted data into a powerful tool to predict disease and accelerate cures. In this episode, we talk to Matt Schwartz, CEO and co-founder of Virgo Surgical Video Solutions, a company at the forefront of this transformation.
Every year, over 20 million GI endoscopies are performed in the U.S., generating a massive amount of high-definition video that, until now, was simply deleted. We dive deep with Matt on how Virgo developed a seamless system for endoscopy video capture, using a small hardware device and a HIPAA-compliant cloud platform to automatically record, de-identify, and store this valuable data without changing the clinical workflow. This enormous dataset, comprising billions of video frames, is the fuel for Virgo’s groundbreaking endoscopy foundation model, EndoDINO. Matt explains how this model, pre-trained on an unprecedented scale of real-world video, can achieve state-of-the-art results in tasks like identifying anatomical landmarks and scoring ulcerative colitis severity. The most exciting application? Using AI for clinical trial endpoints. Matt reveals how EndoDINO was able to predict with remarkable accuracy (an AUROC of 0.78) whether a patient with ulcerative colitis would respond to a placebo, a breakthrough that could revolutionize how pharmaceutical companies design and run clinical trials, making them faster and more efficient. We also discuss the future of this technology, including the potential to analyze the GI tract to find early signs of cardiovascular and neurodegenerative diseases.
About Our Guest:
Matt Schwartz is the CEO and Co-founder of Virgo Surgical Video Solutions. A biomedical engineer who previously worked as a product manager at Intuitive Surgical on the DaVinci robotic surgery platform, Matt was inspired to found Virgo after realizing the immense, untapped potential of endoscopy video data. He saw an opportunity to build the infrastructure to capture this "treasure trove" of data and use it to power a new generation of AI that could fundamentally improve patient outcomes and even eliminate the need for certain surgeries altogether.
Timestamps:
(00:00) Intro: The Problem with Wasted Endoscopy Data
(01:12) Introducing Virgo: Tapping into Underutilized Video Feeds
(06:02) What is an Endoscopy Foundation Model?
(13:12) The Spark for Virgo: A Challenging Case at the Mayo Clinic
(16:09) How the Virgo Cloud Platform Automates Endoscopy Video Capture
(23:51) Building EndoDINO: Virgo’s Foundation Model for GI Endoscopy
(30:51) Applying AI to Clinical Trial Endpoints in Ulcerative Colitis
(36:23) How AI Can Revolutionize Pharmaceutical Trials
(39:11) Why Virgo Embraced a Hardware Component
(41:41) The Future: Predicting Systemic Disease from the GI Tract
Learn More & Episode Resources:
How can a brilliant oncologist, computer scientist, and former top FDA official fix the slow, broken, and expensive system of clinical trials? In this episode, we sit down with Dr. Amy Abernethy, a true physician innovator, to uncover the critical need for streamlining clinical research with real-world data. Dr. Abernethy has spent her career tackling one of healthcare’s biggest challenges: how to get effective treatments to the patients who need them, faster. From pioneering research at Duke to scaling a startup to a multi-billion dollar acquisition and modernizing the FDA’s entire data infrastructure, she reveals the playbook for building a true learning health system.
In this deep-dive conversation, Dr. Amy Abernethy shares her incredible physician innovator career path, which took her from the clinic at Duke University to executive roles at Flatiron Health, the FDA, Verily, and now as the co-founder of Highlander Health. She begins by detailing her early academic work building a "Center for Learning Healthcare," where she focused on using patient-reported outcomes and electronic data to understand what treatments truly work. However, she hit a ceiling in academia, realizing that the grant-based model couldn't scale. This led to her pivot to industry and Flatiron Health, where she shares invaluable lessons on scaling health tech companies. Dr. Abernethy discusses the importance of creating a common language ("lingua franca") between clinicians, engineers, and product teams, and establishing a North Star through shared corporate values.
This experience was crucial for her next chapter at the U.S. Food and Drug Administration, where she served as Principal Deputy Commissioner. Dr. Abernethy provides a rare insider's look at the immense challenges and surprising speed of government work, particularly her focus on FDA data modernization. She explains how the looming wave of cell and gene therapies and the EVALI vaping crisis created an urgent need for a cloud-forward, scalable agency capable of using real-world data for regulatory decisions. This work in advancing real-world evidence in regulatory science set the stage for her current mission. Now in "founder mode" at Highlander Health, she is building the infrastructure for the future of evidence generation by both funding non-profit research and investing in key companies like Target RWE, continuing her lifelong mission of streamlining clinical research with real-world data. This episode is a masterclass for anyone interested in health tech, public policy, and the future of medicine.
ABOUT OUR GUEST:
Dr. Amy Abernethy is a physician, researcher, and health tech leader who is currently the co-founder of Highlander Health. Her distinguished career includes roles as a medical oncologist and researcher at Duke University, Chief Medical Officer and Chief Scientific Officer at Flatiron Health, Principal Deputy Commissioner of the U.S. Food and Drug Administration (FDA), and a leader in product development at Verily. She is a world-renowned expert in real-world data, evidence generation, and building learning health systems.
TIMESTAMPS:
(00:00) Introduction to Dr. Amy Abernethy's Trailblazing Career
(02:19) The Origin Story: From NASA Programmer to Clinical Oncologist
(05:35) Building a "Learning Health System" at Duke University
(07:57) The Pivot from Academia to Industry: Why Scale Matters
(10:10) Lessons in Scaling a Mission-Driven Health Tech Company
(15:54) Shaping the Narrative for Real-World Evidence (RWE)
(18:43) From Industry to Government: A New Chapter at the FDA
(22:27) Modernizing FDA Data Systems for Future Health Crises
(27:39) Founder Mode: The Launch of Highlander Health
(35:41) Advice for Aspiring Physician Innovators
LEARN MORE FROM OUR GUEST / EPISODE RESOURCES:
In modern medicine, a patient's outcome often depends less on the skill of their doctor and more on the speed and efficiency of the hospital system itself. When workflows break down, critical time is lost, and lives are put at risk. This episode provides a comprehensive analysis of the Viz.ai AI healthcare platform, a company at the forefront of solving this problem by using artificial intelligence to detect disease earlier and coordinate care faster. We are joined by Viz.ai's co-founder and CEO, Chris Mansi, a former neurosurgeon who saw firsthand how fragmented communication could lead to devastating consequences and set out to build a solution.
How can a simple software platform save lives in cases of stroke, pulmonary embolism, and cancer? In this deep dive, we explore the rise of Viz.ai, from its initial breakthrough in AI for stroke detection to its current status as a unicorn company installed in over 1,800 hospitals. We dissect how their technology optimizes AI in clinical workflows, not just by flagging critical findings on medical images, but by mobilizing entire care teams in real-time. The discussion covers the "time is brain" philosophy that drives the company’s mission and the powerful real-world evidence, backed by over 100 publications, demonstrating how this approach reduces treatment delays and improves patient outcomes. This has allowed Viz.ai to expand far beyond stroke to tackle aortic disease, hypertrophic cardiomyopathy, cancer, and more, proving the power of a unified platform.
We also analyze the company's evolving business strategy, particularly the crucial role of Viz.ai pharma partnerships. These collaborations with companies like BMS, Sanofi, and Medtronic are not just a revenue driver; they are essential for expanding the platform's reach into chronic diseases and ensuring that life-saving treatments get to the right patients. The conversation then shifts to the incredible Chris Mansi founder story, as the CEO himself recounts the patient story that inspired him to leave neurosurgery and become an entrepreneur. He shares invaluable insights from navigating the complex worlds of FDA clearance and CMS reimbursement, and what it takes to build a mission-driven company. Finally, we look to the future, discussing the biggest barriers to AI adoption in healthcare and Chris's vision for an "AI doctor assistant" that will augment physicians, reduce care variability, and democratize access to the best treatments available.
About Our Guest:
Chris Mansi is the Co-founder and CEO of Viz.ai. A former neurosurgeon trained in the UK, Chris experienced the systemic delays in patient care firsthand. While at Stanford's Biodesign program, he saw the potential for deep learning to fix these broken workflows, leading him to found Viz.ai in 2016. He has since led the company to become a health tech unicorn, pioneering new regulatory and reimbursement pathways for AI in medicine.
Timestamps / Chapters:
(00:00) Introduction
(01:01) What is Viz.ai? A Pioneer in AI-Powered Clinical Workflows
(02:10) How AI Expedites Care for Stroke, PE, and Aortic Disease
(05:40) Beyond the Algorithm: Optimizing Care Coordination & Reducing Variability
(07:12) From Acute Care to Chronic Disease: The Pharma Partnership Model
(14:55) The Viz.ai Origin Story with CEO Chris Mansi
(21:13) Navigating FDA Clearance & CMS Reimbursement as an AI Pioneer
(26:42) How Viz.ai Decides Which Medical Problems to Solve Next
(32:28) The Strategy Behind Pharma & MedTech Partnerships
(35:49) What Are the Biggest Barriers to AI Adoption in Healthcare?
(39:15) Viz.ai's 5-10 Year Vision: The AI-Powered Doctor's Assistant
(41:20) Leadership Lessons from a Unicorn CEO
Most clinicians are forced to manage chronic diseases with just a few data points a year. Dr. Lucienne Ide, a physician-turned-CEO, founded Rimidi to change that.
In this insightful conversation from HLTH 2025, Dr. Ide shares her journey from the exam room to the C-suite and explains how her company is making remote patient monitoring (RPM) a seamless, equitable, and financially sustainable standard of care.
Listen to learn why a clinician-first approach is critical for technology adoption, how new reimbursement models are unlocking access to remote care, and what the future of connected health—from CGM to ambient monitoring—truly looks like.
Learn more about Rimidi’s work in chronic care management at rimidi.com.
The energy from HLTH 2025 was incredible, and we're excited to share one of our most insightful conversations recorded live from the conference. Although the event has wrapped, the ideas discussed are setting the agenda for the year ahead.
In this episode, Dr. Tim Showalter sits down with Antoine Pivron, Head of Healthcare Solutions at Withings, the company bridging the gap between consumer-friendly design and clinical-grade data.
Withings is known for its smart scales, blood pressure monitors, and sleep trackers, but its biggest impact may be in the B2B world. Antoine details the company's strategic shift from wellness to medical, focusing on how to build devices that drive engagement for all patients—even those who aren't tech-savvy.
Tune in to explore the critical role of connected health in the new era of chronic care.
Key Topics Discussed:
In another special episode recorded live from the floor of the HLTH 2025 conference, Dr. Tim Showalter sits down with Jacob Hansen, Chief Product and Technology Officer of AvaSure.
AvaSure is a leader in intelligent virtual care, powering over 5,000 deployments in 1,100 hospitals with its virtual sitting and nursing platform. Jacob discusses how AvaSure's unique, nurse-centric approach to product design (15% of their team are nurses) is critical to building technology that clinicians actually trust and use.
In this conversation, Jacob unveils major new partnerships with Suki, to integrate ambient clinical documentation, and Verizon, to leverage private 5G for rapid, reliable deployment in hospitals. He shares how AvaSure is tackling healthcare's biggest challenges—patient safety, workforce productivity, and clinician burnout—and "bringing the joy back to the bedside."
Tune in to hear how AvaSure is delivering millions in financial value, reducing staff attrition, and leveraging its massive data asset to prove clinical efficacy. Finally, Jacob shares his vision for the future of in-hospital care: the rise of "agentic AI" that moves beyond simple models to create true, outcome-driven solutions.
In this special episode of HealthTech Remedy, recorded live from HLTH 2025, Dr. Paul Gerrard sits down with Roland Dias, a leader at GE Healthcare, to discuss the profound transformation happening at the intersection of medical devices, data, and artificial intelligence.
Roland shares his unique career journey—from Medtronic to Microsoft and now GE Healthcare—and explains how his background in both devices and cloud AI is shaping their new patient-centric strategy.
Tune in to explore:
This conversation is essential listening for anyone interested in how one of healthcare's largest incumbents is pivoting to become a digital-first company and what it means for the future of patient care.
We're recording live from the HLTH conference for a special series! In this episode, Dr. Tim Showalter is joined by Dr. Kim Boyd, the new Chief Medical Officer at Weight Watchers.
Dr. Boyd discusses the iconic brand's massive transformation from a weight-loss giant into a comprehensive clinical care provider. She details their new focus on midlife and metabolic health, including the launch of "WeightWatchers for Menopause," a holistic program that integrates telehealth clinicians, hormone replacement therapy (HRT), and lifestyle support.
In this conversation, Dr. Boyd dives deep into:
This is a must-listen for anyone interested in the future of metabolic health, women's health, and the business of health tech.
Don't forget to like, subscribe, and follow HealthTech Remedy for more special episodes live from the HLTH conference!
In this special bonus episode, we explore the world of venture capital for medical diagnostics with an industry titan. Ever wondered what it takes to get an early-stage health tech startup funded? We're sitting down with Michele Colucci, the founder and managing partner of DigitalDx Ventures, a venture capital fund focused on personalized medicine and diagnostics. Michele, a serial entrepreneur and attorney turned investor, unpacks the complex process of identifying and funding the companies that will shape the future of healthcare. This episode tackles the core problem for so many innovators: how to secure capital and navigate the treacherous path from a scientific breakthrough to a commercially viable product.
Michele Colucci shares the origin story of DigitalDx Ventures and their unique investment thesis: funding companies that enable earlier, less invasive, and more accurate diagnoses through technology. She reveals her firm's rigorous 72-point evaluation framework, a machine-learning algorithm used to vet the hundreds of companies they see each month and separate hype from true potential. A major focus of the conversation is the reality of AI in medical diagnostics. Michele explains that while technology is a critical enabler, true AI is often not necessary or even relevant for many innovations; the key is digitizing biological signals to gain new insights.
We dive deep into the most significant hurdles for founders, including the critical importance of scientific validation and why so many academic papers fail to be replicated at scale. Michele offers invaluable fundraising advice for health tech founders, emphasizing the need to clearly articulate the problem you're solving, prove your science, and build trust through transparency. The discussion also covers the immense challenges in diagnostic reimbursement, exploring how new payment models from employers and direct-to-consumer approaches are creating opportunities outside of traditional payers like Medicare. Finally, Michele breaks down the trends shaping the future, from the rise of non-invasive diagnostic technology and point-of-care solutions to the "box" problem, where companies oversaturate the market with proprietary hardware. This is a masterclass in what it takes to succeed in the high-stakes field of venture capital for medical diagnostics.
About Our Guest:
Michele Colucci is the Founder and Managing Partner of DigitalDx Ventures, an early-stage venture capital fund in Silicon Valley focused on personalized medicine diagnostics and targeted therapeutics. A lawyer, serial entrepreneur, and philanthropist, Michele has dedicated her firm to investing in technologies that move healthcare from late-stage reaction to early-stage prevention. Drawing from personal experience and a desire to solve systemic problems, she has built a global network of experts to identify and support companies that make diagnostics more accessible, accurate, and equitable for all patient populations.
Timestamps / Chapter:
(00:00) Introduction to the Investor Series
(00:53) From Serial Entrepreneur to Health Tech Investor: The Story of DigitalDx
(10:16) The Hype vs. Reality of AI in Medical Diagnostics
(13:03) An Investor's Diagnostic: The 72-Point Framework for Evaluating Startups
(16:26) The Critical Role of Scientific Validation in Health Tech Fundraising
(21:19) Navigating the Gauntlet of Diagnostic Test Reimbursement
(26:18) Emerging Diagnostic Technologies: From Point-of-Care to the "Box" Problem
(33:20) From a Single Test to a Platform: A Founder's Guide to Scaling
(35:28) Fundraising Advice for Founders: How to Pitch and Build Investor Trust
Learn More From Our Guest / Episode Resources:
Is new hospital technology making clinicians' jobs harder instead of easier? While a wave of digital tools promised to revolutionize care, many have only added to the administrative burden, leading to widespread clinician burnout. This episode dives into a company aiming to reverse that trend with the Artisight smart hospital platform, a system designed to give hospitals digital eyes and ears to automate tasks and let clinicians focus on what matters: patient care. We're joined by Artisight's co-founder and CEO, Dr. Andrew Gostine, to discuss his vision for a "keyboard-free hospital."
We unpack how the Artisight smart hospital platform is transforming hospital operations from the ground up. The platform is an ambient intelligence infrastructure that uses a network of cameras, microphones, and IoT sensors to create a real-time process improvement engine. By combining computer vision, voice recognition, and on-device AI, Artisight automates workflows, enhances patient safety, and boosts efficiency. This approach represents a true clinician-led health tech innovation, born from CEO Dr. Andrew Gostine's own frustrations with clerical burdens during his medical training.
We explore how this technology addresses some of healthcare's most persistent problems. A key focus is AI for patient fall reduction, where the platform has demonstrated the ability to cut fall rates by as much as 90%. Beyond safety, we discuss the critical issue of reducing clinician burnout with technology. By automating tasks like nursing documentation and streamlining communication, Artisight has helped its partner hospitals reduce nurse turnover by over 50%. The conversation also covers the high-stakes environment of the operating room, detailing how operating room optimization AI can improve coordination, automate timestamps, and even create predictive schedules to enhance throughput. Throughout the episode, we analyze Artisight's privacy-first model, which uses on-device processing and temporary databases to ensure HIPAA compliance, and the strategic backing from investors like NVIDIA that is fueling its rapid expansion into hundreds of hospitals.
About Our Guest:
Dr. Andrew Gostine is the co-founder and CEO of Artisight and a practicing critical care anesthesiologist. His journey to founding Artisight was shaped by unique experiences outside of traditional medicine, including running a contract research organization and working in venture capital at a high-frequency trading firm. Witnessing the stark contrast between ultra-low latency technology in finance and the slow, pager-based communication in hospitals sparked his mission. A particularly grueling six-hour ordeal to coordinate patient pre-op checks—a task he later automated with software in just six weeks—was the catalyst for his vision of a smart hospital that could automate clerical and clinical tasks, giving time back to providers.
Learn More From Our Guest / Episode Resources:
Timestamps / Chapters:
(00:00) Introduction
(01:30) What is Artisight? The Keyboard-Free Hospital Vision
(04:05) The Power of Clinician-Led Health Tech Innovation
(05:08) A Privacy-First Approach to Hospital Data
(08:18) Wows & Woes: The Promise and Peril of a Full-Stack Platform
(12:07) Origin Story: Dr. Andrew Gostine on Turning Frustration into Innovation
(19:10) What Does a Smart Hospital Actually Look Like?
(24:22) The #1 Metric: Reducing Clinician Burnout & Nurse Turnover
(31:40) How AI is Revolutionizing Operating Room Optimization
(35:45) The Strategy Behind Investors like NVIDIA
(39:42) Advice for Aspiring Physician Innovators
How does a physician’s clinical experience become the blueprint for systemic change? What does it take to pivot from the exam room to the C-suite of a health tech company? This episode is a masterclass for any physician who believes the healthcare system is broken and wants to be part of building the solution.
We're joined by Dr. Melissa Welch, Chief Medical Officer of Sprinter Health, a physician innovator whose 40-year career provides a playbook for turning clinical insights into scalable, tech-powered solutions. Dr. Welch’s journey is a powerful example of how physicians can drive meaningful change from outside the traditional clinic walls.
In this conversation, Dr. Welch charts her unscripted career path, from her formative years at San Francisco General Hospital during the AIDS epidemic to a pivotal role at Health Catalyst. It was there she learned to leverage data and technology to improve quality outcomes—a skill set that became critical for her next chapter. She shares the core insight that has driven her entire career: simply building a clinic isn't enough if systemic barriers prevent patients from accessing care.
This realization ultimately led her to Sprinter Health, where she now leads the clinical vision for a truly innovative care delivery model. Dr. Welch breaks down how Sprinter is solving the “last mile problem” by deploying a unique W2 workforce of phlebotomists trained as community health workers. Supported by sophisticated logistics and virtual clinical oversight, this team delivers comprehensive, “one-and-done” preventative care visits directly in patients’ homes. Dr. Welch offers an insider’s look at how this model works, why it’s a game-changer for health equity, and provides actionable advice for the next generation of physician innovators who want to build the future of healthcare.
About Our Guest:
Dr. Melissa Welch is the Chief Medical Officer of Sprinter Health and a physician innovator with a 40-year career dedicated to designing and leading new systems of care. She leverages her deep experience in public health and community-based clinics to break down structural barriers to access. Her journey has taken her from frontline clinical work in San Francisco to executive roles at InnovAge and Health Catalyst, culminating in her current mission to redefine in-home care delivery with a scalable, tech-forward approach.
Timestamps:
(00:00) Introduction to Physician Innovators
(01:52) From Clinician to Public Health Leader: Dr. Welch’s Origin Story
(08:29) An Early Insight: Identifying Systemic Barriers to Care
(10:58) The Tech Pivot: How Health Catalyst Shaped a Data-Driven Perspective
(13:06) The Innovator's Mission: Why Dr. Welch Joined Sprinter Health
(15:58) Inside the Innovation: What is a Sprinter Health Visit?
(21:03) The Workforce Model: Solving the Last Mile with a W2 Community Team
(22:45) Scaling Innovation: The Technology Powering Sprinter Health
(24:49) The Physician Innovator's Playbook: Advice for the Next Generation
(26:40) Final Thoughts: Why the Future of Healthcare is in the Home
Is the traditional healthcare system broken? Hims & Hers is betting on it. In this episode, we do a deep dive into the disruptive Hims & Hers business model, a vertically integrated virtual care platform that has grown from a niche startup to a profitable public company with millions of subscribers. We explore how their approach to direct-to-consumer healthcare challenges the brick-and-mortar system by prioritizing access, affordability, and consumer convenience. We're also joined by Hims & Hers' Chief Medical Officer, Dr. Patrick Carroll, who shares an inside look at how the company is scaling its next-generation care model.
From treating stigmatized conditions like hair loss and erectile dysfunction to expanding into complex chronic care, Hims & Hers has built a powerful flywheel of services. We break down how their full-stack system, complete with a proprietary EMR, in-house pharmacies, and custom-compounded medications, creates a seamless patient experience. A cornerstone of this is the asynchronous care model, which allows for efficient, high-quality, 24/7 interactions between patients and a network of nearly 3,000 providers. Dr. Patrick Carroll explains how this model is fundamental to providing affordable care and achieving high patient satisfaction without the friction of traditional appointments.
We also explore the company's strategic expansion, particularly with the Hims & Hers for weight management program. Dr. Carroll reveals compelling data on their personalized GLP-1 program, which has shown remarkable patient retention and efficacy thanks to a combination of custom dosing and high-touch clinical support involving millions of patient messages. Looking forward, we discuss Hims & Hers' plans to tackle menopause, men's hormone support, and at-home diagnostics, further pushing the boundaries of the direct-to-consumer healthcare landscape. Finally, for clinicians and aspiring entrepreneurs, the conversation concludes with invaluable career advice, as Dr. Carroll shares insights from his journey and offers a roadmap for a successful physician career in health tech.
About Our Guest:
Dr. Patrick Carroll is the Chief Medical Officer of Hims & Hers. A board-certified family physician with over 30 years of clinical experience, Dr. Carroll has followed a non-linear career path dedicated to solving healthcare's biggest challenges: access and affordability. His journey includes formative years with the Indian Health Service, leadership roles in large medical groups like Atrius Health, and serving as the Chief Medical Officer of Walgreens, where he led their retail health and digital strategy before joining Hims & Hers in 2019.
Timestamps / Chapters:
(00:00) Introduction: A New Model for Healthcare?
(01:19) The Rise of Hims & Hers: From Niche Startup to SPAC Success
(03:36) Deconstructing the Hims & Hers Business Model
(05:23) Regulatory Hurdles of Direct-to-Consumer Healthcare
(11:59) A Physician's View: Integrating Hims & Hers into Specialty Care
(16:20) The Future of Hims & Hers: Expanding into Chronic Disease
(18:52) Meet Dr. Patrick Carroll, CMO of Hims & Hers
(26:12) The Secret Sauce: How the Asynchronous Care Model Drives Quality
(33:00) Inside the Hims & Hers for Weight Management Program (GLP-1s)
(42:20) Building a Better EMR: The Hims & Hers Tech Stack & AI Future
(46:22) Dr. Carroll's Advice: A Physician Career Path in Health Tech
Have you ever felt the pressure to follow a traditional career path, even when your gut tells you to forge a different one? For many doctors, the path is clear: train, practice, repeat. But what happens when your passion for impact extends beyond the bedside? This episode features one of the leading physician innovators who faced this exact dilemma and made the difficult choice to leave clinical practice for a career in technology and venture capital. We explore the emotional and professional challenges of stepping away from a traditional medical career and how that pivot can lead to an even greater scale of impact.
In this deep-dive conversation, Dr. Rebecca Mitchell, Co-founder and Managing Director of Scrub Capital, shares her incredible journey. We begin with her upbringing in rural Wisconsin, where early experiences with a strained healthcare system and personal loss due to medical errors ignited her passion to innovate in care delivery. Dr. Mitchell discusses the pivotal moment during medical school at UCSF when she realized her true calling was not in day-to-day practice but in building systems to scale medical expertise. This led her to a successful career in digital health product leadership, where she was instrumental in scaling remote patient monitoring programs at companies like Validic with Kaiser Permanente and, most notably, Livongo. At Livongo, she helped expand the company from a single-condition diabetes platform to a multi-condition service that treated over 10 million patients, showcasing the immense impact physician innovators can have in the tech industry.
Now, Dr. Mitchell is channeling that experience into her next chapter with Scrub Capital, a venture capital firm built on a powerful thesis: that early-stage health tech startups are more successful when guided by a diverse community of clinician investors. She explains how Scrub Capital functions, its focus on pre-seed to Series A companies, and its unique "community pitch" process that involves dozens of clinicians in the investment evaluation. This conversation provides an invaluable look at the burgeoning world of clinician-led venture capital and offers practical advice for doctors considering alternative career paths for physicians. Dr. Mitchell’s story is a compelling case study for any medical professional who believes their impact can be amplified through technology, business, and embracing a nonlinear career.
Timestamps:
(00:00) The Modern Dilemma for Physician Innovators
(01:29) Introducing Scrub Capital: A Clinician-Led Venture Capital Firm
(03:52) Dr. Mitchell's Origin Story: From Rural Healthcare to a Global Mission
(06:06) The Turning Point: Navigating the Difficult Decision to Leave Clinical Practice
(14:05) Lessons in Digital Health Product Leadership: A Livongo Case Study
(17:43) The Scrub Capital Thesis: The Value of a Diverse Clinician Community
(21:18) Inside the Investment Process: How Scrub Capital Evaluates Startups
(25:11) Does Scrub Capital Invest in Biotech and Drug Development?
(26:09) Advice for Aspiring Physician Innovators: Embracing Risk and the Nonlinear Path
(27:35) Final Thoughts
In a world of increasingly complex cancer care, how can oncologists ensure they have the most accurate, up-to-date information at the exact moment of need? For years, life-saving clinical guidelines have been buried in dense, hard-to-search PDF documents, creating a significant barrier to evidence-based decision-making. This episode dives into a groundbreaking solution that uses AI for oncology guidelines to solve this existential problem. We're joined by Dr. Clifford Hudis, CEO of the American Society of Clinical Oncology (ASCO), and Aashima Gupta, Global Director of Healthcare at Google Cloud, to discuss their revolutionary partnership.
They reveal the inside story behind the ASCO Guidelines Assistant, a new tool designed to provide instant, reliable answers to complex clinical questions. Discover how this powerful tool is not just a search engine, but a sophisticated system built on the principles of trustworthy AI in medicine. This is a deep dive into how technology can transform patient care by empowering clinicians and making critical knowledge more accessible than ever before.
In this detailed discussion, Dr. Hudis and Aashima Gupta explain the core challenges that led to the ASCO and Google Cloud collaboration. For busy clinicians, the process of finding the right information within hundreds of pages of guidelines was becoming an unwieldy and time-consuming task. The episode explores how the ASCO Guidelines Assistant, powered by Google's Gemini model, addresses this by improving clinician workflow with AI. We unpack the unique technical framework behind the tool, including the use of Retrieval Augmented Generation (RAG) to ensure every answer is based only on ASCO's vetted guidelines and includes direct citations to the source material. This commitment to accuracy and transparency is crucial for building trust and ensuring safe application in a clinical setting.
The conversation also highlights the rigorous "expert in the loop" process, where a panel of oncologists continuously evaluated and refined the AI's responses to ensure clinical relevance and safety. Dr. Hudis emphasizes a key feature: the tool's built-in "humility," meaning it will explicitly state when it doesn't have an answer within the guidelines, a deliberate choice to prevent the "hallucinations" common in other generative AI models. Looking to the future, the discussion expands to cover how AI will reshape all of healthcare, from unlocking new frontiers in science with initiatives like AlphaFold to restoring the doctor-patient relationship by automating documentation. As Aashima Gupta notes, the era of AI is here, and "doctors who use AI will replace doctors who don't use AI."
About Our Guests:
Dr. Clifford Hudis is the CEO of the American Society of Clinical Oncology (ASCO), the world's leading professional organization for physicians and oncology professionals caring for people with cancer. He shares the story of why ASCO saw an existential need to innovate beyond traditional PDF guidelines and partner with a tech leader to better serve its members and their patients.
Aashima Gupta is the Global Director of Healthcare at Google Cloud. She provides insight into the technical architecture that makes the ASCO Guidelines Assistant a reliable and trustworthy tool, explaining how the collaboration exemplifies Google's vision for applying AI to solve critical challenges in medicine and improve patient outcomes.
Timestamps / Chapters:
(00:00) Introduction: The Central Role of ASCO in Oncology
(05:45) The Problem: Why Accessing Cancer Treatment Guidelines is So Difficult
(10:03) Inside the ASCO and Google Cloud Collaboration
(13:07) The Technology Behind the ASCO Guidelines Assistant
(16:59) Expert in the Loop: The Rigorous Process of Building Trustworthy AI
(21:13) Why "Humility" is a Critical Feature of This Medical AI
(23:42) Early Reception and How the Tool is Driving Continuous Improvement
(27:24) The Future: How AI Will Reshape Healthcare (Access, Affordability & Science)
(35:44) Advice for the Next Generation of Physicians Embracing AI
(39:09) "Doctors Who Use AI Will Replace Doctors Who Don't"
How can a full-time academic surgeon launch not one, but two successful health tech companies? This episode features one of the leading physician innovators, Dr. Jim Daniero, who shares the real story of how he went from a traditional NIH-funded academic path to a serial entrepreneur. We uncover the "aha" moments and chance encounters that led him to found two startups while maintaining his clinical practice, tackling the core challenge of how to translate medical ideas from the lab to the bedside.
In this deep dive, Dr. Jim Daniero, a practicing laryngologist at the University of Virginia, details his incredible journey and provides a playbook for other doctors with an entrepreneurial itch. He explains how getting involved with the Cville BioHub and angel investment groups provided him with a crucial education in commercialization. We explore the origin story of RefluxRaft, a company born from identifying a gap in the market for effective, accessible non-pharmaceutical solutions to reflux. Dr. Daniero discusses how he built the company around a platform of patient education and trust, creating an over-the-counter alginate product that has resonated with consumers. This story is a masterclass in translating medical research into products with a low regulatory burden. We then shift to his second venture, SonoFx, which takes a more traditional biotech route. Dr. Daniero shares the challenges and long timelines involved in developing novel biomaterials for vocal fold injury, a project that started with university research and NIH funding. Throughout the conversation, Dr. Daniero offers invaluable advice on balancing clinical practice with entrepreneurship, emphasizing the power of building strong teams and finding alignment between his university duties and his founder roles. This is a must-watch for any physician or academic considering a leap into the startup world.
ABOUT OUR GUEST:
Dr. Jim Daniero is a practicing laryngologist and faculty member at the University of Virginia. A serial entrepreneur, he is the co-founder of SonoFx, a company developing hydrogel-based devices for vocal fold injury, and RefluxRaft, which provides a non-pharmaceutical alginate solution for reflux. Dr. Daniero is also a board member of the Cville BioHub and serves as a venture advisor for UVA Innovates, guiding other faculty members through the startup process. He shares his story of how he continues to balance his full-time clinical and academic duties with his passion for innovation and entrepreneurship.
TIMESTAMPS:
(00:00) Introduction to the Physician Innovators Series
(01:43) Dr. Daniero's Journey: From Academic Surgeon to Founder
(04:40) The "And" Not "Or": Still a Full-Time Faculty Member
(05:10) Origin of RefluxRaft: A Chance Encounter & A Market Need
(07:25) Building a Brand on Education and Trust
(11:04) The Story of SonoFx: Translating Medical Research into Products
(12:15) Developing Biomaterials for Vocal Fold Injury
(14:20) Balancing Clinical Practice with Entrepreneurship
(16:20) Final Advice for Aspiring Physician Innovators
(17:50) What is a UVA Wahoo?
Hospitals are a critical, yet incredibly expensive part of our healthcare system. So why are so many operating on razor-thin margins, with some even facing bankruptcy? The answer lies in a massively complex and broken billing system, leading to billions in hospital revenue leakage every year. This episode explores a groundbreaking solution: using AI for hospital revenue cycle management to ensure hospitals are paid accurately for the care they provide. We're joined by Dr. Michael Gao and Dr. Joshua Geleris, the physician co-founders of SmarterDX, a company tackling this crisis head-on.
In this deep-dive discussion, the HealthTech Remedy team and the founders of SmarterDX unpack the intricate challenges of hospital finances. We explore the historical complexities of the Diagnosis-Related Group (DRG) system and how tens of thousands of ICD-10 codes create a nightmare for manual coders, leading to frequent errors and costly claim denials. This environment is precisely where physician-led innovation can make a difference. We analyze how SmarterDX's platform leverages clinical documentation improvement AI to find missed diagnoses and justify the care provided, a crucial step to reduce hospital revenue leakage. The discussion covers SmarterDX's two core products: Smarter Prebill, which reviews claims before submission, and Smarter Denials, which provides automated claims denial management by generating evidence-backed appeal letters in minutes. Co-founders Dr. Gao and Dr. Geleris share their founding story, which began when they discovered their own names on lists of attending physicians with missed diagnoses at New York Presbyterian. They explain why the combinatorial complexity of medical coding makes it a perfect problem for AI to solve and how their technology delivers a guaranteed 5-to-1 ROI, adding millions in net new revenue for health systems without requiring new staff. This conversation provides a masterclass in applying AI for hospital revenue cycle management to solve a critical, real-world problem in healthcare operations.
About Our Guests:
Dr. Michael Gao is the co-founder and CEO of SmarterDX. Before founding the company, he was the Medical Director of Transformation at New York Presbyterian, where he led various AI initiatives and first identified the immense opportunity to improve clinical documentation with technology.
Dr. Joshua Geleris is the co-founder of SmarterDX and a Columbia-trained bioinformatics researcher. His expertise in software and data science, combined with his experience as a physician, was instrumental in building the powerful AI engine that drives SmarterDX's ability to accurately interpret complex clinical data.
Timestamps / Chapters:
(00:00) Introduction: A Broken System
(01:50) The Extreme Complexity of Hospital Revenue Cycle Management (RCM)
(06:01) Why Are Hospital Margins So Dangerously Low? The DRG Problem
(09:26) How SmarterDX Fixes Revenue Leakage with Smarter Prebill & Smarter Denials
(12:06) The Physician-Led Team Behind SmarterDX
(13:02) The Business Case: Guaranteed ROI & Seamless EHR Integration
(17:31) Interview: The Founding Story of SmarterDX
(24:32) Why Hospital Billing is So Broken (A Historical Accident)
(27:27) Why AI is the Perfect Tool for Clinical Documentation Improvement
(30:11) A Deep Dive into SmarterDX's Products
(33:40) The Real-World Impact: Saving Hospitals & Improving Quality of Care
(38:20) The Guardrails: How SmarterDX Prevents Over-Coding
(41:12) What's Next? The New Mountain Capital Partnership
(43:24) Career Advice for Physicians in Health Tech
Is a detailed career plan the key to success, or is the secret to follow your curiosity and build what's missing in the world? In this episode of HealthTech Remedy, we explore the nontraditional career path of a true physician innovator, Dr. Gaurav Singal. He shares why abandoning a rigid plan in favor of serendipity and a passion for building led him from medicine to the forefront of health technology. This episode unpacks the story of a physician who has consistently identified problems in healthcare and built the technology to solve them, offering invaluable lessons for anyone looking to merge a clinical background with an entrepreneurial spirit.
Dr. Gaurav Singal's physician entrepreneur journey is a masterclass in applying technical skills to solve real-world medical challenges. He candidly shares his origin story, from an early love for computer science and robotics to a circuitous entry into medicine, not with a plan to practice, but to understand the human body as a machine that could be fixed with technology. This builder's mindset first emerged in medical school, where he created solutions for his peers out of necessity, most notably the platform Rotating Room - a marketplace for short-term housing for medical students and professionals that is now used by every medical school in the country. We then dive into his experience at MGH building what would become Qpid Health, where he harnessed natural language processing (NLP) to extract critical, unstructured information from the electronic medical record (EMR), dramatically improving provider access to patient history and saving countless hours of manual chart review.
The core of our conversation explores Dr. Singal's defining role as Chief Data Officer at Foundation Medicine. He details the vision behind building the revolutionary Foundation Medicine real-world data platform, linking the world's largest cancer genomics dataset with clinical records from partners like Flatiron Health. This effort created the clinical genomic database, a powerful tool that accelerated research, enabled novel trial designs, and established new business lines in clinical trial matching and recruitment. Dr. Singal's story is a testament to the power of a physician innovator to create entirely new categories within a life sciences company. Looking to the future, he shares his excitement for what's next: bringing AI in clinical decision support directly to the bedside to turbocharge physicians and fundamentally improve patient outcomes.
About Our Guest:
Dr. Gaurav Singal is a practicing physician at Brigham and Women's Hospital, a faculty member at Harvard Medical School, and a technologist, executive, investor, and advisor in the health tech and biotech ecosystem. His career is distinguished by his role as Chief Data Officer at Foundation Medicine, where he built its pioneering real-world data platform. Dr. Singal’s journey showcases how a physician innovator can create transformative solutions, from early-stage ventures like Qpid Health to industry-defining data businesses. He continues to advise and invest in companies at the intersection of diagnostics, data science, and therapeutics.
Timestamps:
(00:00) Welcome to the Physician Innovator Series
(02:15) Dr. Gaurav Singal's Origin Story: From Computer Science to Medicine
(04:28) Career by Serendipity: Why Having No Plan Was an Advantage
(07:43) The Builder's Itch: How Personal Necessity Led to Creating Rotating Room
(13:09) The Qpid Health Story: Using NLP in the EMR to Solve Clinical Problems
(22:18) Joining Foundation Medicine: Building a Data Powerhouse
(25:58) Creating the Foundation Medicine Real-World Data Business
(28:31) Advice for the Next Generation of Physician Innovators
(31:14) The Next Frontier: Bringing AI to the Clinical Bedside
Is the healthcare system drowning in paperwork and phone calls? The U.S. healthcare system spends over $80 billion annually on administrative tasks, a hidden tax that slows down patient care and burns out clinicians. Much of this cost comes from endless, inefficient phone calls for things like prior authorizations and benefits verification. This episode explores a transformative solution using AI for healthcare administration to automate these frustrating conversations and create a more efficient, "weightless" healthcare system. We're joined by Ankit Jain, the founder and CEO of Infinitus Systems, who is pioneering this change.
In this deep dive, we uncover the true scale of the administrative burden in medicine, where physicians can spend up to 15 hours a week on the phone for tasks that 98% of the time result in an approval anyway. This friction not only creates delays but can even have a chilling effect on care, as providers may avoid treatments they anticipate will be a bureaucratic nightmare. We explore how Infinitus Systems is leveraging sophisticated voice AI in healthcare to tackle this problem head-on. Ankit Jain explains how their technology, born from his experience at Google, goes beyond simply making calls. It navigates complex Interactive Voice Response (IVR) menus, engages in real-time conversations with payer representatives, and uses a proprietary knowledge graph to push back against incorrect information, correcting errors in real-time. This focus on prior authorization automation has already saved over 100 million minutes of conversation time for their partners.
We also discuss how to reduce healthcare administrative costs and the critical importance of building trustworthy AI in healthcare. Ankit details the safety guardrails Infinitus has built to avoid "hallucinations" and ensure every action complies with pre-approved protocols and regulations like HIPAA and SOC 2. We explore the difference between a fully autonomous Voice AI Agent and a Voice AI Co-pilot, which works alongside human staff to eliminate tedious work like waiting on hold. Finally, Ankit Jain of Infinitus shares his personal journey into health tech, offering powerful advice for anyone looking to build a career at the intersection of technology and healthcare.
About Our Guest:
Ankit Jain is the Founder and CEO of Infinitus Systems. A former engineering leader at Google who also helped start Google's AI venture fund, Gradient Ventures, Ankit has a deep background in technology and machine learning. The inspiration for Infinitus came from a conversation with his wife, a healthcare professional, who highlighted the immense potential for voice AI to solve the crippling administrative bottlenecks she and her colleagues faced daily.
Timestamps / Chapters:
(00:00) The $80 Billion Problem in Healthcare Administration
(03:08) Why Prior Authorization is a Broken System for Doctors and Patients
(05:43) The Vision for a "Weightless" Healthcare System with Infinitus
(08:27) How Voice AI Automates 100 Million Minutes of Phone Calls
(16:31) A Conversation with Ankit Jain, CEO of Infinitus Systems
(19:12) The "Fraud, Waste, and Abuse" Tax That Burdens Everyone
(22:13) Ankit Jain's Journey from Google's AI Fund to Solving Healthcare's Headaches
(24:33) What Are Voice AI Agents and Voice AI Co-Pilots?
(30:19) Building Trustworthy AI with Safety Guardrails and Context
(35:24) Ankit Jain's Career Advice for Health Tech Innovators