55: Paternal Exercise Epigenetics: Sperm microRNAs Transmit Endurance to Offspring

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Listen, Learn, Adapt

Anthony Novello

77 episodes

3 days ago

Evidence over everything. Health and wellness is full of noise. We provide the signal. We break down the latest in physical medicine, rehab, and pain science—one research article at a time. No opinions. No "hacks." Just clear, actionable evidence for athletes, clinicians, and the health-conscious human. Understand the science. Master your movement. Dr. Anthony Novello, PT, DPT @anthonynovello.dpt

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Health & Fitness

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55: Paternal Exercise Epigenetics: Sperm microRNAs Transmit Endurance to Offspring

Listen, Learn, Adapt

15 minutes 9 seconds

2 months ago

55: Paternal Exercise Epigenetics: Sperm microRNAs Transmit Endurance to Offspring

This episode details experimental evidence demonstrating that paternal exercise in mice, either via treadmill training or muscle-specific genetic overexpression of PGC-1α, transmits enhanced endurance capacity and metabolic health to offspring.

Yin X, Anwar A, Yan L, Yu R, Luo Y, Shi L, et al. Paternal exercise confers endurance capacity to offspring through sperm microRNAs. Cell Metab. 2025;37:1-18. doi:10.1016/j.cmet.2025.09.003.

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