Proteostasis is the ability of cells to maintain the proper folding, assembly, and degradation of proteins, which is essential for their normal functioning. The loss of proteostasis is a hallmark of aging and can lead to the accumulation of misfolded or aggregated proteins, which can be harmful to cells and tissues. In this episode, Dr. Swasti Raychaudhuri explains how fasting can help with the loss of proteostasis. Fasting can stimulate a cellular process called autophagy, which is responsible for degrading and recycling damaged or misfolded proteins. Autophagy helps to maintain proteostasis by preventing the accumulation of toxic proteins in the cells. Thus, fasting may help to prevent age-related diseases by improving proteostasis and reducing cellular damage. Dr. Swasti Raychaudhuri is a highly qualified and experienced scientist with a strong academic background from CCMB. He completed his post-graduation in Biotechnology from the University of Calcutta in 2002, following which he pursued her PhD in Biophysical and Biological characterization of Huntingtin Interacting Protein HYPK at the same university, graduating in 2008. Dr. Swasti's postdoctoral research focused on protein misfolding and stress response at the Max Planck Institute for Biochemistry, where he worked from 2008 to 2013. During his postdoctoral research, he gained valuable insights into the mechanisms underlying protein misfolding and its link to various diseases, as well as the cellular stress response that helps to prevent or mitigate damage caused by protein misfolding. His extensive academic and research background makes him a valuable asset to the scientific community, and his expertise in the field of proteostasis and aging is evident in his work and research.