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🍐 In this episode of PodBites, Omar Al Refaiee and Abdallah Kharsa break down alcohol metabolism — following ethanol from absorption to breakdown, and explaining why this everyday substance causes such wide-ranging clinical effects.
🎙️ Tune in to explore:
How alcohol is absorbed, distributed, and eliminated
The two-step breakdown: ADH → acetaldehyde → ALDH
Why acetaldehyde causes flushing and hangover symptoms
The role of NADH excess in lactic acidosis and hypoglycemia
MEOS (CYP2E1) and drug–alcohol interactions
Genetic differences behind Asian flush syndrome
Chronic alcohol complications: fatty liver, cirrhosis, and neurotoxicity
Key clinical ties like thiamine deficiency and disulfiram
🌟 A high-yield, clinic-linked breakdown that turns alcohol metabolism from trivia into something you can actually reason through.
