In this episode of the RevGenetics Podcast, Les and Amy dive into a groundbreaking shift in how we understand gut health and supplement efficacy. While the gut microbiome is essential for everything from digestion to immune function, studying it has always been a challenge because most beneficial gut bacteria die when exposed to oxygen.

Enter the G3GC tool—a revolutionary mini-gut replica developed at Utrecht University. This innovation finally allows scientists to mimic the low-oxygen environment of the human gut lining with incredible precision. We explore how this "gut-on-a-chip" technology is being used to test how substances such as inulin, resistant dextrin, and spermidine interact with our unique internal ecosystems.

Join us as we unpack why your gut supplements might work differently from your neighbor's and how this research is paving the way for a new era of personalized, science-backed gut health solutions.

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Support your gut from the inside out!
One of our gut-health winners, RevGenetics Spermidine supports intestinal health, cellular function, and longevity.
Get yours today from RevGenetics’ official store:
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Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity & Gut Health Products

Referenced Study:
🔗 Effect of inulin, resistant dextrin, and spermidine on the gut microbiome using Gut3Gel Gradient Colonic as an in vitro substrate

Hashtags:
#GutHealth #Microbiome #RevGenetics #Longevity #G3GC #GutScience #UtrechtUniversity #Probiotics #Prebiotics #Spermidine #Inulin #DigestiveHealth #HealthTech #Biohacking #ScienceBreakthrough #PersonalizedNutrition #HealthyAging #ImmuneSystem #GutMicrobiome #RevGeneticsPodcast

In this episode of the RevGenetics Podcast, Les and Amy explore a critical breakthrough in respiratory health: the potential of Spermidine to treat life-threatening conditions like Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).

A recent study highlights how Spermidine acts as a cellular shield, protecting the lung lining from catastrophic inflammation by enhancing autophagic flux—the body's natural "recycling" process. In cases of ALI, the lungs are often overwhelmed by pyroptosis, a violent form of programmed cell death that leads to fluid accumulation and severe breathing difficulties. Les and Amy break down how Spermidine’s powerful antioxidant properties can combat this destructive process, offering a beacon of hope for patients facing severe pulmonary challenges. Join us as we unpack the science behind this molecule and its role in protecting our most vital organs.

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity Products

Referenced Study:
🔗 Spermidine mitigates lipopolysaccharide‑induced acute lung injury by enhancing autophagic flux

#Spermidine #LungHealth #ALIAwareness #ARDS #LongevityResearch #Autophagy #RevGenetics #RespiratoryHealth #CellularHealth #AntiInflammatory #ScienceBreakthroughs #HealthyAging #SpermidineBenefits #MedicalResearch #PulmonaryHealth #Biohacking #DeepDivePodcast #CellSurvival #AntioxidantSupport #RevGeneticsPodcast

In this episode of The Deep Dive, supported by RevGenetics, Les and Amy explore a groundbreaking breakthrough in the fight against aging: Procyanidin C1 (PCC1), a powerful compound found in grapeseed extract. This "dual-mode" senotherapeutic is changing the way we look at cellular senescence—the process where aging cells stop dividing but refuse to die, turning into "zombie cells."

These senescent cells aren't just idle; they secrete a toxic mix of inflammatory compounds known as SASP (Senescence-Associated Secretory Phenotype), which damages neighboring healthy cells and accelerates the aging process across the entire body.

PCC1 offers a revolutionary two-pronged approach to this problem:

• At Low Doses: It acts as a senomorphic, effectively silencing these zombie cells and stopping the production of harmful SASP.
• At Higher Doses: It transforms into a targeted senolytic, selectively triggering the death of senescent cells to clear them out entirely while leaving healthy cells unharmed.

Join us as we unpack how this natural compound from grapeseed could be a key to "pan-organ" rejuvenation and a more vibrant, longer life.

---

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity Products

Referenced Study:
🔗 Procyanidin C1: A Natural Dual‑Mode Senotherapeutic for Pan‑Organ Senescence Modulation and Clearance

Hashtags:
#PCC1 #Longevity #CellularSenescence #AntiAging #GrapeseedExtract #Senolytics #HealthyAging #RevGenetics #ZombieCells #SASP #Biohacking #DeepDivePodcast #LifeExtension #Senotherapeutics #ScienceBreakthrough #PanOrganClearance #BiologicalAging #NaturalLongevity

In this episode of the RevGenetics Podcast, Les and Amy explore a monumental shift in medical philosophy: treating aging itself as the root cause of chronic disease. We delve into the cutting-edge science of preventative care, focusing on the "hallmarks of aging" like cellular senescence and epigenetic alterations to understand how we can stay healthier for longer.

We break down how new interventions aim to clear out "zombie cells" and fix DNA management issues that lead to systemic decline. While lifestyle changes are essential, the conversation shifts to the frontier of geroprotectors—natural compounds and drugs designed to target underlying biological markers. Specifically, we look at recent research into histone deacetylase (HDAC) inhibitors and their potential to extend chronological lifespan by addressing the root causes of aging.

Join us as we unpack the implications of this new approach and what it means for the future of longevity and overall health.

Give your body the boost it deserves! Promote cellular health and healthy aging with the RevGenetics Longevity Starter Pack.
Get yours today from RevGenetics’ official store:
👉 Get The Longevity Starter Pack Here

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity Products

Referenced Study:
🔗 Combinations of histone deacetylase inhibitors extend chronological lifespan in S. cerevisiae

#Longevity #AntiAging #Geroprotectors #CellularHealth #Epigenetics #Senescence #RevGenetics #HealthyAging #Biohacking #ScienceBreakthroughs #DNAHealth #ChronicDiseasePrevention #LifeExtension #Healthspan #Podcast #AgingResearch #HDACInhibitors #MedicalInnovation #RevGeneticsSupport

In this episode, Les and Amy from RevGenetics delve into the fascinating science behind TA-65, a specialized molecule derived from Astragalus membranaceus that is making waves in anti-aging research. Known for its unique ability to activate telomerase—a repair enzyme essential for cellular health—TA-65 works to slow down telomere shortening, a primary driver of biological aging.

We break down the findings from key clinical trials, including the TACTIC study, where TA-65 demonstrated the ability to stabilize the aging clock. The results suggest powerful potential for protection against major age-related challenges, such as heart disease and immune system decline. By targeting aging at the cellular level, could TA-65 be the key to extending not just lifespan, but healthspan?

Join us as we unpack the cellular mechanisms of this molecule and what it could mean for the future of longevity, immunity, and overall vitality.

Support your cellular health and aging wellness with TA-65.
Order today through RevGenetics’ official store:
👉 https://www.revgenetics.com/products/ta-65-telomerase-activator

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity Products: https://www.revgenetics.com

Referenced Study:
🔗 TA-65 and Telomerase Study

In this episode of the RevGenetics Podcast, Les and Amy explore a surprising breakthrough in regenerative medicine: fat's critical role in tissue repair and hair regrowth. A recent study reveals that fat does far more than just store energy; it is a key player in healing and regeneration.

The study found that even minor skin damage can trigger a powerful regenerative response by activating stem cells through fatty acid signaling. The research uncovers a fascinating communication cascade: immune cells (macrophages) respond to injury, releasing signals that "awaken" dormant fat cells (adipocytes). These adipocytes then use fatty acid signaling to activate hair follicle stem cells, jumpstarting the repair process and promoting new hair growth.

This discovery shatters the old view of fat as mere energy storage, highlighting its crucial role as a dynamic player in tissue regeneration. Could this new understanding redefine our approach to healing and anti-aging?

Join us as we unpack the implications of this study and what it might mean for the future of regenerative medicine, skin health, and longevity science.

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
👉 Explore Longevity Products

Referenced Study:
🔗 Adipocytes promote tissue regeneration and hair follicle growth Study

Hashtags:
#TissueRegeneration #StemCells #FatMetabolism #HairGrowth #LongevityResearch #RevGenetics #RevGeneticsPodcast #SciencePodcast #RegenerativeMedicine #Adipocytes #FatSignaling #SkinRepair #AntiAging #LongevityScience #Macrophage #HairFollicle #ScienceBreakthroughs #CellMetabolism #HealthyAging #BiologyBreakthrough #ImmuneSystem

In this episode of The Deep Dive, supported by RevGenetics, we explore how the world’s oldest people may hold the key to treating one of the rarest aging diseases, Hutchinson-Gilford Progeria Syndrome (HGPS).

HGPS is caused by a mutation in the LMNA gene, which produces a toxic protein called progerin that causes rapid aging. However, super centenarians, people who live beyond 110 years, have a special LMNA gene variant that helps protect their cells from progerin damage.

Researchers now believe this longevity variant could help protect children with HGPS from early heart problems, especially diastolic dysfunction, an early sign of heart failure. This study offers new hope for immediate heart protection and a better understanding of how some humans naturally resist aging.

Join us as we explore the connection between genetic longevity and progeria research, and what it could mean for longer, healthier lives.

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
Explore Longevity Products

Referenced Study:
Supercentenarian LMNA Variant and HGPS – Nature Cell Discovery

Hashtags:
#Progeria #HGPS #LongevityResearch #SuperCentenarians #LMNAGene #RevGenetics #HealthyAging #AntiAgingScience #HeartHealth #Progerin #GeneticLongevity #CellularResilience #LongevityPodcast #AgeReversal #ScienceBreakthroughs #CardiovascularResearch #LongevityPotential #DeepDivePodcast #RevGeneticsSupport

In this episode of The Deep Dive, supported by RevGenetics, we explore a surprising breakthrough in longevity research: psilocybin, the active compound in magic mushrooms, may do more than just improve mental health.A recent study published by the Japanese Society of Anti-Aging Medicine introduces the psilocybin telomere hypothesis, suggesting that psilocybin’s mood-enhancing effects could be linked to telomere length, a key marker of cellular aging. In lab tests, psilocin, a metabolite of psilocybin, showed the ability to improve cell survival and extend lifespan in aging human cells.Even more compelling, older mice treated with psilocybin showed signs of enhanced survival and vitality, opening the door to a bold new direction in anti-aging science. Could psilocybin influence biological aging itself?Join us as we unpack the implications of this study and what it might mean for the future of longevity, mental wellness, and telomere science.Supported by RevGenetics – Science-Based Supplements For Healthy Aging 👉 [Explore Longevity Products](https://www.revgenetics.com)Referenced Study:🔗 [Psilocybin and Telomeres Study – Nature](https://www.nature.com/articles/s41514-025-00244-x)Hashtags:#Psilocybin #LongevityResearch #TelomereScience #HealthyAging #PsilocybinPodcast #AntiAgingMedicine #RevGenetics #PsilocinStudy #DeepDivePodcast #MentalHealthAndAging #ScienceBreakthroughs #CellularLifespan #TelomereLength #PsilocybinLongevity #MushroomMedicine #Neurobiology #LongevityPotential #AntiAgingBreakthrough #PsychedelicScience #RevGeneticsSupport

Can aging be reversed? A landmark 2025 Cell study says… maybe. Scientists engineered human senescence-resistant mesenchymal progenitor cells (SRCs) and infused them into aged primates,with mind-blowing results.

These SRCs didn’t just slow aging, they reversed biological age in key organs like the brain, bones, and reproductive system. Cognitive performance improved. Brain volume and connectivity bounced back. Even fertility markers surged in both male and female subjects.

The secret? SRCs released exosomes, tiny vesicles packed with rejuvenating signals, that triggered wide-scale cellular repair and anti-inflammatory effects across the body. From improved memory and myelination to restored spermatogenesis and oocyte health, this research opens new doors for regenerative therapies targeting aging at the root.

While human trials are still on the horizon, this could mark a turning point in the science of longevity and systemic rejuvenation.

Join us as we explore the science behind this game-changing breakthrough.

👉 Subscribe for More Longevity Updates: https://www.youtube.com/revgenetics
👉 Get Longevity Support From RevGenetics: https://www.revgenetics.com/collections/longevity-supplements

Referenced Study:
🔗 Cell (2025): Senescence-Resistant Cells Reverse Aging in Primates
https://doi.org/10.1016/j.cell.2025.05.021

Hashtags:
#LongevityBreakthrough #AntiAgingResearch #SenescenceResistance #StemCellTherapy #BrainHealth #ReproductiveHealth #CognitiveSupport #RegenerativeMedicine #HealthyAging #ExosomeTherapy #BiologicalAgeReversal #FOXO3 #FutureOfMedicine #RevGenetics #LongevityScience #PrimatesToPeople #StemCellNews #AgingReversal #RegenTech #SRCs

In this RevGenetics podcast, Les and Amy introduce the new advanced NAD supplement with a special delivery system in BioVXR capsules. The formula addresses challenges with NAD breakdown by NNMT enzyme, using NAD shield with an NNMT inhibitor and low-dose NAD precursor strategy. Ingredients include NAD precursor, trans resveratrol for antioxidant properties, and NNMT inhibitor from vanilla beans. Probiotics Bifidobacterium infantis and Lactobacillus salivarius support gut health for better nutrient absorption. This targeted approach offers a promising solution for boosting NAD levels and promoting healthy aging. Study: https://cdn.shopify.com/s/files/1/2088/8715/files/Eurofins_-_Capsule_Tests.png?v=1733770624 https://cdn.shopify.com/s/files/1/2088/8715/files/MUV1cm9maW5zX0Rpc2ludGVncmF0aW9uIFJlcG9ydC5wZGY_1.pdf?v=1733769841 Get Advanced NAD + NADshield Here: https://www.revgenetics.com/products/advanced-nad-and-nadshield-nnmt-inhibitor-stop-nad-deficiency

In this podcast by RebGenetics, we explore peripheral nerve regeneration. When nerves are damaged, they can regrow, but the process is slow and doesn't always lead to full recovery. Wallarian Degeneration breaks down the injured nerve, paving the way for regrowth. Schwann cells act as cleanup crew and guide axon regrowth. Time and distance affect recovery, making it a race against time. Electrical stimulation, like post-operative and conditioning stimulation, can aid in nerve regeneration by providing guidance and support. Overall, understanding the complexities of nerve regeneration can help improve recovery outcomes.

In this podcast, we explore the groundbreaking potential of **NMN (Nicotinamide Mononucleotide)**, a crucial molecule for **NAD+ production** in the body. As NAD+ levels naturally decline with age, NMN emerges as a promising solution to combat age-related health issues. Recent studies, including a groundbreaking **Nature study**, highlight NMN's ability to protect neurons and synapses critical for memory and cognition, offering hope in the fight against **Alzheimer's disease**. By activating the **ATF4 pathway**, NMN helps clear harmful proteins linked to Alzheimer's, showcasing its neuroprotective benefits. NMN is also gaining attention for its role in **fertility**. Research suggests NMN supports mitochondrial health, improves oocyte quality, and may help address age-related fertility challenges. These findings underscore NMN's dual potential to improve both cognitive function and reproductive health. While research is still in preclinical stages, the possibilities for **longevity** and **healthspan enhancement** are compelling. Join us for a deep dive into the transformative potential of NMN! **Referenced Studies:** 🔗 [Study 1](https://www.nature.com/articles/s41419-024-07062-1) 🔗 [Study 2](https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1480617/full) 🔗 [Study 3](https://www.sciengine.com/ABBS/doi/10.3724/abbs.2024167;JSESSIONID=009a062c-0115-4c3c-b85e-ef7e777a97e2) 🔗 [Study 4](https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01903-4) **Get RevGenetics Advanced NMN 1000 (60 Caps - 500 mg each):** 👉 [RevGenetics Advanced NMN](https://www.revgenetics.com/collections/advanced-nmn-products/products/advanced-nmn-1000-nicotinamide-mononucleotide-limited-production) #NMNAlzheimers #NMNFertility #NMNResearch #NADBoosters #AlzheimersResearch #FertilitySupport #LongevityScience #HealthyAging #MitochondriaHealth #ATF4Pathway #BrainHealth #CognitiveSupport #AgeRelatedFertility #Podcast #ScienceBreakthroughs #RevGenetics

Discover the incredible potential of spermidine for longevity and reproductive health in this podcast! Spermidine, a natural polyamine found in all living organisms, plays a vital role in cellular health. Cutting-edge research reveals that spermidine supplementation can help combat cellular deterioration, enhance **oocyte quality** in aging females, and even slow down the aging process.

Exciting studies also suggest that spermidine may improve fertility by boosting sperm binding and increasing fertilization rates in aged oocytes, offering hope for couples dealing with age-related fertility challenges. Dive in as we explore how spermidine is transforming the fields of anti-aging and reproductive science, showcasing its immense potential for improving quality of life.

**Referenced Studies:**

🔗 [Research Study 1](https://assets-eu.researchsquare.com/files/rs-4966373/v1/d2083cc8-b013-46e9-bd24-08c6d60bc720.pdf?c=1729174608)

🔗 [Research Study 2](https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01881-7)

🔗 [Research Study 3](https://www.semanticscholar.org/paper/Harnessing-Mitophagy-for-Therapeutic-Advances-in-Ghosh-Kumar/a9be508d021f6cbdf453e437ec7baaa5de9d0c2e)

🔗 [Research Study 4](https://link.springer.com/article/10.1007/s10571-024-01493-2)

🔗 [Research Study 5](https://academic.oup.com/ismecommun/article/4/1/ycae123/7826681?login=false)

**Get Spermidine Supplements Here:**

👉 [RevGenetics Spermidine Supplements](https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx)

#Spermidine #Longevity #ReproductiveHealth #FertilitySupport #AntiAging #CellularHealth #OocyteQuality #FertilityScience #AgeRelatedFertility #HealthyAging #Podcast #BreakthroughResearch #NaturalSupplements

In today's podcast, we explore the exciting potential of resveratrol in addressing COVID-19 and Parkinson's disease. Researchers have discovered that resveratrol targets critical processes in lung damage, offering hope for reducing infection and scarring. Using advanced virtual models, they’ve observed how resveratrol interacts at a molecular level, suggesting promising therapeutic effects. For Parkinson's disease, cutting-edge science is investigating nanoparticle delivery systems to optimize resveratrol's benefits, paving the way for groundbreaking treatments. Dive into the latest research and learn how this natural compound is shaping the future of medicine. **Referenced Studies:** 🔗 [De Gruyter Study](https://www.degruyter.com/document/doi/10.1515/chem-2024-0012/html) 🔗 [PubMed Study 1](https://pubmed.ncbi.nlm.nih.gov/39400013/) 🔗 [PubMed Study 2](https://pubmed.ncbi.nlm.nih.gov/39395579/) 🔗 [PubMed Study 3](https://pubmed.ncbi.nlm.nih.gov/39426178/) 🔗 [Preprint Study](https://www.preprints.org/manuscript/202410.0596/v1) **Get Resveratrol or Polydatin Here:** 👉 [RevGenetics Resveratrol Supplements](https://www.revgenetics.com/collections/resveratrol-supplements) **Hashtags:** #Resveratrol #COVID19Research #ParkinsonsDisease #LungHealth #Nanotechnology #CuttingEdgeScience #RevGenetics #NaturalMedicine #HealthInnovation #ScientificBreakthroughs

Can eating make us age faster? 🧐 In this video, we take a fascinating deep dive into the science of aging and digestion. Research suggests that as we age, digestive enzymes like trypsin and elastase may leak out of the gut, wreaking havoc on our organs and collagen. These enzymes, designed to break down food, can mistakenly start breaking down other parts of our bodies, potentially contributing to wrinkles, sagging skin, and other aging effects.

A recent study found that older rats had higher levels of these enzymes, leading to significant collagen damage in various organs. The connection between leaky gut, rogue enzymes, and collagen breakdown sheds new light on how our bodies change with age.

We also discuss natural trypsin inhibitors found in foods like egg whites, soybeans, sweet potatoes, and more, and how they could play a role in managing this process.

Stay tuned for more on the link between digestion and aging—this is one video you don’t want to miss!

Trypsin Inhibitor-Rich Foods:

🥚 Egg Whites

🌱 Soybeans

🍠 Potatoes & Sweet Potatoes

🌾 Amaranth Seeds

🍲 Beans, Lentils, & Peas

Hashtags:

#AgingScience #LeakyGut #CollagenHealth #Wrinkles #SkinCareTips #AntiAging #DigestiveHealth #NaturalRemedies #HealthyAging #GutHealth #ScienceOfAging #TrypsinInhibitors Study: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312149 Get 120 Capsules of Spermidine (25 mg each) Here: https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx

In this podcast, researchers explore the link between gut health and fighting off MRSA infections. They found that antibiotics disrupting gut bacteria made mice more susceptible to severe MRSA infections. However, fecal transplants from healthy mice improved infections drastically. The key molecule identified was spermidine, produced by gut bacteria. Mice with higher spermidine levels showed improved survival rates and reduced infection severity when infected with MRSA. Spermidine seemed to boost the immune system's response to the infection. This research highlights the importance of gut health in combating antibiotic-resistant superbugs like MRSA. Study: https://pubs.acs.org/doi/epdf/10.1021/acsinfecdis.3c00669?ref=article_openPDF Get 120 Capsules of Spermidine (25 mg each) Here: https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx

In this Podcast, we explore cutting-edge cancer research on the mitochondrial stem cell connection (MSCC). Published in September 2024, this study challenges traditional views by focusing on cellular energy crises. The MSCC theory suggests that malfunctioning mitochondria in stem cells can trigger tumor formation, leading to aggressive cancer growth. Cancer cells, desperate for energy, become "sugar addicts," relying on glucose and glutamine for fuel. This research highlights seven key points, emphasizing the importance of understanding how cellular energy processes impact cancer development. Stay tuned for more insights into this fascinating and groundbreaking study that provides dose and information on Intravenous Vitamin C, Oral Vitamin D, Zinc, Ivermectin, Benzimidazoles (Mebendazole), DON, Dietary Interventions and Additional Therapeutics. Study: https://isom.ca/article/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol/ Support RevGenetics by purchasing a world class NMN, M98 Resveratrol (Polydatin), Spermidine, Or Fisetin Supplement: https://www.revgenetics.com/collections/longevity-supplements

Scientists are exploring how aging impacts COVID severity, focusing on lung aging and cellular senescence. As we age, our lungs lose efficiency in repair mechanisms, like basal cells and cilia, making us more vulnerable to infections. Cellular senescence leads to zombie cells releasing inflammatory molecules, creating an inflammatory soup that affects healthy cells. This process, known as SASAP, worsens with SARS-CoV-2 infection, potentially explaining why COVID hits some harder than others. By understanding these aging-related factors, researchers hope to develop new strategies like Senolytics to combat COVID and improve outcomes. Study: https://link.springer.com/article/10.1186/s13619-024-00201-1 Try RevGenetics Senoyltics Supplement available here, for your next study: https://www.revgenetics.com/collections/longevity-supplements/products/senolytics-500-fisetin-500mg

In this podcast, we explore a study on whether chocolate high in flavanols can protect skin from the sun. Flavanols are antioxidants found in cocoa beans, fruits, and vegetables. The study involved women aged 20-65 consuming chocolate daily for 12 weeks. Researchers measured skin protection using the minimal erythema dose (MED), which indicates sun sensitivity. By tracking MED changes, they assessed the impact of chocolate consumption on skin reaction to UV radiation. The study aimed to determine if flavanols in chocolate could provide additional antioxidant protection for the skin. Stay tuned to learn more about the fascinating findings! Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082621/ Longevity Supplements: https://www.revgenetics.com/collections/longevity-supplements