Why did the FDA deny sotagliflozin —even with strong data showing heart, kidney, and glucose benefits? In this episode, Dr. Steve Edelman sits down with special guest Stacey Simms to break down the full story behind SGLT inhibitors and their complicated path in type 1 diabetes.
Together, they walk through how SGLT inhibitors transformed type 2 diabetes care, why many clinicians believe people with type 1 should have access, and how the risk of DKA shaped the FDA’s decision. Dr. Edelman also shares insights on who might benefit, how to reduce risk, and why continuous ketone monitoring could be a game-changer for future approvals.
They also touch on the growing discussion around GLP-1 medications in type 1 diabetes, new study results, and what emerging evidence could mean for future treatment options.
In this episode:
• Sotagliflozin & SGLT Inhibitors in T1D: Why these medications matter and what the latest data shows.
• The FDA Denial: Understanding the DKA concerns and why approval remains challenging.
• Real-World Experience: How clinicians are using SGLT inhibitors safely today in select patients.
• Continuous Ketone Monitoring: Why dual-analyte sensors could unlock safer use in T1D.
• GLP-1s in Type 1 Diabetes: What recent research reveals about potential benefits.
• Who Might Benefit Most: Kidney protection, heart health, and metabolic improvements.
• Looking Ahead: How ongoing studies and patient advocacy could shape future guidelines
Learn more about Diabetes Connections with Stacey Simms: https://diabetes-connections.com
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Continuous glucose monitoring didn’t start as sleek apps and tiny sensors — it began with chunky receivers, short wear times, and a lot of skepticism. In this episode, Dr. Jeremy Pettus and Dr. Steve Edelman sit down with Dexcom CEO and original sensor engineer Jake Leach to trace the evolution of CGM from those early “Tylenol-shaped” receivers and repurposed pagers to today’s G7 system and beyond.
They walk through the major turning points: abandoning long-term implants for subcutaneous sensors, proving that real-time CGM meaningfully improves time in range and safety, and pushing back against old-school thinking that insisted patients shouldn’t see their own data. From STS 3-Day to Seven Plus, G4, G5, G6, and now G7, Dr. Edelman, Dr. Pettus, and Jake Leach break down what each generation added — better accuracy, easier insertion, smartphone and cloud connectivity, and integration with pumps and AID systems.
Most importantly, Dr. Edelman, Dr. Pettus, and Dexcom CEO Jake Leach, focus on what’s coming next and what it means for people living with diabetes today: the 15 day Dexcom G7 sensor, Smart Basal insulin titration for people with type 2 diabetes, AI-powered food logging, and the upcoming G8 platform designed to measure multiple analytes (glucose plus ketones and more) — all while pushing toward broader access and affordability.
Key Topics:
0:23 - Introduction & TCOYD’s 30th Anniversary
1:39 - Meet Jake Leach: 21 Years at Dexcom
3:08 - The Early Days: From Implantable Sensors to Patches
5:26 - The First Commercial CGM (STS 3-Day) & The "Pager" Receiver
8:35 - The Evolution to 7-Day Wear (Seven Plus)
10:15 - The Early Struggles with Insurance Coverage
12:32 - Why Unblinded Real-Time Data Changed Everything
16:36 - The G4 Era: Improved Accuracy & The "Share" Cradle
20:26 - G5: The Shift to Smartphone Connectivity
27:04 - Real Talk: Addressing G7 Connectivity & Sensor Failures
29:07 - Dexcom's "Unlimited Replacement" Policy for Failed Sensors
31:39 - CONFIRMED: The New 15-Day Sensor Launch
32:43 - "Smart Basal": A New Tool for Type 2 Diabetes
35:44 - G8 Reveal: Measuring Ketones, Lactate & Potassium
39:12 - New Feature: AI Smart Food Logging
41:22 - The Future of CGM: Pre-Diabetes & Heart Health
46:34 - Closing Thoughts
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Get a practical breakdown of Afrezza, the ultra-rapid inhaled insulin, with this comprehensive guide to efficacy, timing, and real-world application. Join Drs. Jeremy Pettus and Steve Edelman—endocrinologists living with Type 1 diabetes—as they reveal why this unique tool is often misunderstood and how to use it effectively to flatten post-meal spikes.
In this episode, we move beyond the basics to correct the biggest mistake users make regarding Afrezza dosage. If you’ve tried this therapy before and felt it "didn't work," the issue often lies in the conversion ratio. We review data from Afrezza MannKind studies (such as INHALE-3) to explain the shift from the old 1:1 ratio to the more effective 1:3 ratio. We also cover why this "rapid-on, rapid-off" insulin is the ultimate solution for exercise and how to navigate insurance coverage and prior authorizations.
Topics covered in this episode:
Timecodes:
0:00 Start
0:24 Intro: What is Afrezza?
1:39 "Rapid On, Rapid Off" vs. Injectable Insulin
2:44 Preventing Delayed Hypoglycemia (Lows)
4:03 The Early Dosing Mistake (The 1:1 Ratio)
4:35 Jeremy’s Story: Why He Quit Using It Initially
5:44 The Correct Dosing Conversion (1:2 to 1:3)
8:09 Timing: Do You Need to Pre-Bolus?
9:16 "Follow-On" Doses for High Protein/Fat Meals
11:00 Cartridge Sizes & "Bucket" Dosing Strategy
13:10 Using Inhaled Insulin for Exercise
14:23 Real-World Test: Trix Cereal & Afrezza
15:28 Storage Tips: Fridge vs. Room Temp
16:44 Managing the Cough Side Effect
17:29 Proper Inhalation Technique
19:37 Using Afrezza with Insulin Pumps (Hybrid Closed Loop)
21:54 Pediatric Update: Is it Safe for Kids?
23:11 Why You Must Use a CGM
23:49 Lung Safety, Smokers & Spirometry Tests
24:49 How to Get It Prescribed (Overcoming Doctor Resistance)
26:27 Utilizing Trainers & Prescription Combos
29:08 Conclusion
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Type 1 diabetes doesn’t always travel alone — in fact, it often brings other autoimmune conditions along for the ride. In this episode, Dr. Jeremy Pettus and Dr. Steve Edelman shine a light on the most common ones that tend to show up with T1D, why they happen in the first place, when you should be screened, and what subtle symptoms should raise a red flag.
They walk through what’s common but manageable, like thyroid issues and celiac disease — as well as what’s rare but critical not to miss, like Addison’s disease (adrenal failure), which can be dangerous if left undiagnosed but incredibly treatable once caught early.
Most importantly, Jeremy and Steve explain how simple blood tests can catch these conditions before they spiral, and how the right medication can completely change how you feel day-to-day.
Key Topics:
• T1D & Autoimmunity 101: Why having one autoimmune condition raises your risk for others
• Thyroid Disorders: The most common — hyper vs. hypo, yearly screening, easy treatment
• Celiac Disease: Why it’s up to 10x more common in T1D and often missed without symptoms
• Addison’s Disease Awareness: The “silent” cortisol deficiency you don’t want to miss
• Proactive Care Mindset: How to build autoimmune screening into your diabetes warranty plan
(00:00) Intro: The "Raindrop" Analogy
(02:26) Thyroid Disease: The Most Common T1D Link
(05:25) Hypothyroidism (Low Thyroid): Symptoms & Easy Treatment
(09:30) Hyperthyroidism (Graves' Disease): Symptoms & Cures
(13:25) Your "Diabetes Warranty": Why You Need a Yearly TSH
(14:48) Celiac Disease: The 10% Risk Factor (19:28) Celiac Screening vs. "Gluten Sensitivity"
(25:31) Addison's Disease: The Other One to Know
(29:43) Final Takeaway: Be Your Own Advocate
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Gene therapy isn’t science fiction anymore, it’s becoming one of the most exciting frontiers in diabetes care. In this episode, Dr. Jeremy Pettus and Dr. Steve Edelman sit down with Dr. Fraser Wright, career gene therapist and Co-Founder/Chief Gene Therapy Officer at Kriya Therapeutics, to explore how gene therapy could one day help the body make its own insulin.
Together, they unpack what gene therapy actually is, Dr. P’s involvement as a medical consultant for Kriya Therapeutics, how AAV (adeno-associated virus) vectors work, and what makes this “one-and-done” approach so different from traditional treatments. From success stories in blindness and hemophilia to emerging type 1 diabetes studies, the trio breaks down the science, the safety, and the hope behind this revolutionary research.
You’ll learn how gene therapy has moved from rare diseases to more common ones, why the first human trials in diabetes are on the horizon, and what and what this could mean for long-term blood sugar control and independence from injections.
Key Topics:
0:00 – Intro: Jeremy and Steve introduce gene therapy and why this topic is a game-changer
2:15 – What gene therapy is and how it’s different from standard protein-based treatments
4:54 – Understanding AAV: safety, engineering, and why it’s the preferred delivery method
8:50 – Real-world success: seven FDA-approved AAV therapies for genetic diseases
12:20 – Lessons learned from treating blindness and how they apply to diabetes
17:40 – The Type 1 Diabetes model: using muscle tissue to produce insulin
22:15 – Managing control, glucose sensing, and preventing hypoglycemia
25:50 – Safety measures and how treatment can be reversed locally if needed
28:30 – Exercise, durability, and what animal studies reveal about real-life performance
31:10 – Timelines, trials, and what’s next for gene therapy in diabetes. What’s Ahead: Clinical trials expected to begin around 2026, offering cautious but real optimism for the future of diabetes treatment.
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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The diagnosis of Cushing's Syndrome is often missed because its underlying cause, hypercortisolism, masks itself as 'just diabetes,' 'just stress,' or 'just getting older,' which can lead to serious problems. In this conversation, Dr. Steve Edelman talks with a military veteran named Phil and his wife Cherese about years of unexplained fatigue, tough-to-control blood sugars, and high blood pressure, and the one test that made everything make sense. This episode discusses the early warning signs, how to advocate for answers and the hypercortisolism treatments that helped Phil feel like himself again. You’ll also hear why targeted hypercortisolism treatments and diabetes-specific approvals are on their way.
You’ll learn why hypercortisolism is more common than most people realize, how it can hide behind type 2 diabetes, and what tests and treatments can make a life-changing difference.
Timecodes:
0:00 – What is Cushing's Syndrome (hypercortisolism) & guest setup
0:41 – Steroids & cortisol 101: why persistently high cortisol wreaks havoc
2:01 – Phil’s backstory: diabetes diagnosis and years of “uncontrolled” numbers
4:55 – Escalating meds, rising A1C, growing fatigue—when things stop making sense
7:25 – Cherese’s Story: lifestyle overhaul, then deeper testing when sugars don’t improve
10:47 – Classic signs of Cushing's Syndrome (buffalo hump, thin arms) & sleep issues
11:23 – CATALYST study: up to 1 in 4 with tough-to-control T2D show evidence of hypercortisolism
13:10 – Diagnosing Cushing's: The hypercortisolism suppression test
16:06 – Treatment wins: targeted therapy improves glucose, mood, sleep; “new era” in care
20:45 – Takeaways: Recognizing Cushing's, self-advocacy & red flags
Important Links:
Cortisol in Control website:
https://www.cortisolincontrol.com/
https://www.cortisolmatters.com/patient
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Type 2 diabetes is one of the most common chronic conditions in the U.S., but it doesn’t have to define or limit your life. In this episode, Dr. Steve Edelman and Dr. Jeremy Pettus—two endocrinologists with decades of experience—break down practical strategies for living well with type 2. From the latest medications and tools to everyday lifestyle choices, they highlight what really makes a difference in the long run. Their goal? To show you that type 2 diabetes is not only manageable but that taking control can actually improve your health and quality of life.
Living with type 1 diabetes is a daily grind, full of numbers, decisions, and constant adjustments, but it doesn’t have to feel overwhelming. In this episode, Dr. Steve Edelman and Dr. Jeremy Pettus two endocrinologists who also live with T1D, share their top 10 tips for making life with diabetes more manageable and a little easier to navigate. They cover everything from setting realistic blood sugar goals and understanding the metrics that matter most, to smart supply hacks that can save you stress when you least expect it. They also dive into why celebrating the small wins like getting through the night without a low or nailing your pre-meal insulin timing can make a big difference in your long-term mindset. Whether you’re newly diagnosed or decades into the journey, this episode is packed with advice you can use today and into the future.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Think sleep apnea is just about loud snoring? Think again. This common condition is a serious health issue that affects a staggering number of people with both type 1 and type 2 diabetes. In this eye-opening episode, Dr. Steve Edelman is joined by Dr. Jeremy Pettus, who shares his own recent and unexpected diagnosis of obstructive sleep apnea. From recognizing the subtle symptoms to navigating the diagnosis process and starting treatment, Dr. Pettus offers a firsthand account of what it's like to confront this underdiagnosed condition. This episode is a crucial wake-up call, revealing how untreated sleep apnea can impact everything from your heart health and blood pressure to your energy levels and insulin resistance. Whether you or a loved one has diabetes, this is essential listening.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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What if you could learn about type 1 diabetes before symptoms even appear? In this powerful episode, Dr. Steve Edelman and Dr. Jeremy Pettus sit down with Senior Football Insider and Sanofi Spokesperson Adam Schefter to talk about why early screening for T1D is a conversation every family should be having.
Adam shares his personal connection to type 1 diabetes through his wife’s experience and how it changed his outlook on health, preparation, and the role of care partners. Together, they break down the importance of understanding early-stage T1D, how screening works, and why early knowledge is more than just information—it’s peace of mind.
Whether you’re newly diagnosed, a care partner, or simply looking to stay informed, this episode offers insight, support, and a meaningful call to action.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Managing type 1 diabetes while balancing college sports, academics, and everyday life is no small feat. In this episode, Dr. Jeremy Pettus and Dr. Steve Edelman sit down with two remarkable Dexcom U athletes—baseball pitcher Leo and soccer/track star Amber—to talk about how they're thriving with T1D on and off the field. From diagnosis stories to game-day strategies, device hacks, and mentoring others with diabetes, Leo and Amber open up about what it really takes to perform at a high level while managing their diabetes as well as being a part of Dexcom U. Whether you're a student-athlete, a parent, or just looking for inspiration, this episode is a powerful reminder that diabetes doesn’t have to hold you back.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Conversations about diabetes and health can be awkward—especially when you're a teenager trying to figure it all out. In this episode, Dr. Steve Edelman welcomes diabetes influencer Mary Comeau and pediatric endocrinologist Dr. Manasi Jaiman to break down the real issues young people with type 1 diabetes face when navigating adolescence, independence, and taboo topics like sex, alcohol, marijuana, driving, and overbearing parents. With personal stories, practical advice, and some laughs along the way, this episode is all about helping young adults with T1D build confidence, advocate for themselves, and feel less alone.
Key Topics:
See a whole video series dedicated for teens with Mary and Dr. Manasi Jaiman: tcoyd.org/video-teens-young-adults-type-1-diabetes/
Follow Mary: instagram.com/mary_comeau
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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People living with diabetes often focus on managing blood sugars, medications, and diet — but skin health is an equally important and often overlooked part of the picture. In this episode, Dr. Steve Edelman sits down with Dr. Tanya Nino, a board-certified dermatologist, to explore the skin conditions commonly seen in people with diabetes. From everyday concerns like dry, itchy skin to more serious fungal infections and rare complications like necrobiosis lipoidica, Dr. Nino offers clear explanations, helpful tips, and guidance on when to seek medical care. This episode is packed with practical advice to help people living with diabetes better protect and care for their skin.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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When complications like chronic kidney disease and Type 1 diabetes intersect, it can feel overwhelming. In this episode, Dr. Steve Edelman sits down with Kristen Hohmann, a Type 1 diabetic who underwent both kidney and pancreas transplants, to explore her journey of managing diabetes, overcoming kidney failure, and pursuing the life-changing decision to undergo a dual organ transplant. Kristen shares the emotional, physical, and mental challenges she faced along the way, offering valuable insights into the transplant process and the importance of self-advocacy.
Key Topics:
American Diabetes Association (ADA): diabetes.org
National Kidney Foundation: kidney.org
Mayo Clinic Transplant Services: mayoclinic.org
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Managing Type 1 diabetes is complex, but when an eating disorder like diabulimia enters the picture, it becomes even more challenging. In this episode, Dr. Steve Edelman and Dr. Jeremy Pettus sat down with clinical psychologist Dr. Liana Abascal to explore the psychological and physical impact of eating disorders, particularly diabulimia, in individuals with Type 1 diabetes. They dive deep into the signs, risk factors, and treatment strategies for those struggling with both diabetes and eating disorders.
Key Topics:
Diabulimia Hotline: diabulimiahotline.org
American Diabetes Association (ADA): diabetes.org
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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Managing diabetes isn't just about numbers—it's also about handling the emotional toll that comes with it. In this episode, Dr. Steve Edelman and Dr. Jeremy Pettus sit down with leading diabetes psychologist Dr. Bill Polonsky to unpack the mental health side of living with diabetes. From feeling overwhelmed by constant decision-making to dealing with burnout, they explore the real-life emotional challenges people with diabetes face every day. You'll learn how to recognize the signs of diabetes distress, how it's different from clinical depression, and where to find support that actually helps.
Key Topics:
diabetesdistress.org
behavioraldiabetes.org
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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In this jam-packed episode, Dr. Jeremy Pettus and Dr. Steve Edelman team up with special guest Dr. David Ahn to break down the latest and greatest in diabetes technology for 2025. From extended-wear CGMs to fully automatic hybrid closed-loop pumps and dual-hormonal systems, this episode is your complete guide to what’s available now and what’s coming soon. Whether you’re on MDI, using a pump, or considering a tech upgrade, this conversation will help you navigate the expanding world of devices—and find the right setup for you.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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In this episode, Dr. Jeremy Pettus and Dr. Steve Edelman go head-to-head in a friendly face-off between two of the most talked-about medications in diabetes and weight management: Ozempic and Mounjaro. Both are part of the powerful GLP-1 class, but which one might be better for you? From A1C reduction and weight loss to heart and kidney protection, ease of use, side effects, and insurance coverage—Drs. E & P walk you through a category-by-category comparison. They bring the clinical data and their own real-world patient experience to help you understand the key differences (and similarities) between these leading therapies. Whether you're managing type 2 diabetes, living with type 1, or exploring options for weight loss, this episode is designed to help you make an informed decision with your healthcare provider.
Key Topics:
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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In this episode, Dr. Steve Edelman and Dr. Jeremy Pettus sit down with Sierra Werling, their first patient to ever receive Tzield, to discuss the groundbreaking therapy designed to delay the onset of type 1 diabetes. Sierra shares her personal journey, how she discovered she was at risk for type 1, what led her to pursue the Tzield treatment, and how her life has changed since receiving it. Steve and Jeremy also break down the science behind Tzield, how it works to preserve insulin-producing beta cells, and why early screening for type 1 diabetes is more important than ever. They discuss how delaying the disease can impact long-term health, providing individuals more time to prepare, access new treatments, and potentially reduce complications in the future. This episode highlights a major shift in diabetes care, one that moves beyond just managing type 1 diabetes to proactively delaying its onset. Tune in to hear Sierra’s experience, insights, and what this means for the future of diabetes prevention.
Key Topics:
Screen today: screenfortype1.com
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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In this episode, Dr. Steve Edelman sits down with Michael Killiam, Director of Clinical Services at Pacific Northwest Research Institute, to discuss two groundbreaking studies—TEDDY and Cascade—that have shaped our understanding of genetic and environmental triggers for type 1 diabetes. The TEDDY study, spanning over 20 years and involving nearly 8,800 participants, investigates why some genetically at-risk individuals develop type 1 diabetes while others do not. Cascade builds upon TEDDY’s findings, aiming to integrate early screening into standard healthcare and identify potential preventative interventions. Michael and Dr. Edelman break down the major findings of these studies, including the role of viruses, genetics, and immune responses, and what they mean for the future of type 1 diabetes prevention and treatment.
Key Topics:
Teddy Study: teddy.epi.usf.edu
CASCDE study: cascadekids.org
Visit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org
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