In this episode of the CNTR podcast, we explore how sleep can be used as a biomarker for neurological disease. Dr. Alice Lam and Dr. Alex Bender discuss the central role that sleep may play in the pathophysiology of Alzheimer’s Disease and Epilepsy. This episode highlights how advances in EEG signal processing and machine learning can improve the identification of pathological brain activity. We also touch on an exciting NIH-funded, longitudinal study, ELUCID, which hopes to explain the relationship between late-onset epilepsy and dementia.