In this episode of the CNTR podcast, we explore how sleep can be used as a biomarker for neurological disease. Dr. Alice Lam and Dr. Alex Bender discuss the central role that sleep may play in the pathophysiology of Alzheimer’s Disease and Epilepsy. This episode highlights how advances in EEG signal processing and machine learning can improve the identification of pathological brain activity. We also touch on an exciting NIH-funded, longitudinal study, ELUCID, which hopes to explain the relationship between late-onset epilepsy and dementia.
In this episode, we explore Deep Brain Stimulation (DBS) with CNTR faculty Dr. Darin Dougherty & Dr. Todd Herrington. We focus on how DBS is revolutionizing the treatment of Parkinson's disease, Major Depressive Disorder, and Obsessive Compulsive Disorder. We discuss the recent FDA approval of adaptive DBS in Parkinson’s disease and the exciting future of neuromodulation in psychiatric care. This episode highlights how these transformative technologies are improving lives of patients as we speak.
In this episode, Dr. Rina Zelmann & Dr. Pariya Salami discuss the field of neuromodulation for epilepsy management & treatment. Dr. Zelmann & Dr. Salami, both instructors in Neurology in the Mass General Brigham Department of Neurology at Harvard Medical School, discuss their research on responsive neurostimulation (RNS), a closed-loop system designed to detect and respond to seizures. In our conversation, we examine why the thalamus is a central target for neurostimulation and explore the applications of these devices outside clinical practice, specifically in understanding sleep and consciousness.
In this episode, Dr. Eric Rosenthal and Dr. Sahar Zafar discuss how AI can revolutionize neurocritical care while navigating the challenges of privacy, bias, and data standardization. We explore the importance of inclusivity in AI models, the role of patient perspectives in shaping data privacy policies, and the future of precision medicine in neurocritical care. Dr. Eric Rosenthal is a neurointensivist and neurophysiologist at Massachusetts General Hospital. He is the Medical Director of the Neurosciences Intensive Care Unit, the ICU Director of the MGH Clinical Data Animation Center and a faculty member at the Center for Neurotechnology and Neurorecovery. Dr. Sahar Zafar is also a neurointensivist and neurophysiologist at Massachusetts General Hospital. She is the Medical Director for Inpatient Neurology and is Co-Director of the Center for Value-Based Healthcare and Sciences. She is also an Associate Professor of Neurology at Harvard Medical School and a faculty member at the Center for Neurotechnology and Neurorecovery.
In this episode, Dr. Angelique Paulk and Dr. Sydney Cash discuss recent advances in translational recording technologies. From non-implanted methods to the innovative Neuropixels probes, our guests discuss the implications of high-resolution recordings on neuroscience research and clinical practice. Tune in to discover how these technologies have the potential to improve patient care and what challenges lie ahead in making these tools widely accessible.
Dr. Sydney Cash is the Division Chief for the Clinical Neurophysiology Division at Massachusetts General Hospital. He is a Professor in Neurology at Harvard Medical School, the Principal Investigator of the Cash Lab and a Director of the Center for Neurotechnology and Neurorecovery. Dr. Angelique Paulk is an Instructor in the Department of Neurology at Massachusetts General Hospital. She is on the research staff of the Cash Lab and is a faculty member at the Center for Neurotechnology and Neurorecovery.
In this episode, we explore the field of brain-computer interfaces with Dr. Leigh Hochberg and Dr. Dan Rubin. We discuss how the BrainGate consortium is working to help individuals with paralysis regain movement & communication and examine how decoding neural activity is turning thoughts into action.
Dr. Leigh Hochberg and Dr. Dan Rubin are Neurologists at Massachusetts General Hospital. Dr. Hochberg is the Director of the BrainGate consortium and leads the BrainGate clinical trial, the largest and longest-running clinical trial of an implanted BCI. Dr. Rubin is a principal investigator in the BrainGate Consortium whose research explores the development of electrophysiologic biomarkers and tools to facilitate recovery after neurologic injury.
In this episode, we discuss consciousness in a clinical setting. Covert consciousness is a state where individuals appear unconscious on the bedside examination yet demonstrate signs of awareness through advanced tests of brain function. Together, Dr. Brian Edlow and Dr. Yelena Bodien explain how these tests reveal covert consciousness and how modern neurotechnologies are redefining the clinical evaluation of consciousness in patients with severe brain injuries.
Welcome to the first episode of The CNTR, the podcast from the Center for Neurotechnology and Neurorecovery (CNTR) at Massachusetts General Hospital.
Join us as we dive into the world of neurotechnology with CNTR directors, Dr. Leigh Hochberg and Dr. Sydney Cash. Learn about some historical milestones that have shaped the field, revolutionary clinical trials, and the inspiring stories of how advances in neurotechnology are improving the lives of patients with neurologic diseases.