Dave explains how oxalates quietly damage mitochondria, bind essential minerals, and form inflammatory crystals in the body, why even healthy superfoods can backfire over time, and how to reduce oxalate load safely to improve metabolism, brain fog, pain, and long term longevity without extreme dieting.

This video reveals the hidden mistake most people make when fasting that causes muscle loss instead of fat loss.

This weekly rundown breaks down how drug pricing policy, smarter fasting strategies, cocoa bioactives, organ-specific aging clocks, and skin-focused longevity tech are reshaping what actually works in modern biohacking and prevention.

This episode explores how addiction really works beneath the surface, and shows how long term sobriety is built by rewiring biology, nervous system patterns, and identity rather than relying on willpower alone.

This episode breaks down how aging is driven by modifiable biological systems like insulin signaling, mTOR, mitochondria, and inflammation, and shows how targeted biohacking, nutrition, and functional medicine can slow or even reverse biological age.

This episode uncovers why muscle tone and cognitive power decline early in adulthood and shows how a simple, science-backed supplement can restore ATP production, sharpen memory, improve stress and sleep resilience, and slow age-related deterioration when used correctly.

This episode breaks down five cutting-edge findings in supplements, cardiac diagnostics, detox science, psychedelics and metabolic control, and mitochondrial aging to reveal how emerging research can translate into practical upgrades for your health and longevity.

Dave Asprey explores how conscious intimacy and erotic experience create real altered states of consciousness through the body’s own chemistry, revealing why desire, surrender, and learning to ask for what you want can transform how you show up in life, work, and relationships.

This episode lays out the blueprint for having healthier children later in life by treating preconception as the most important window for human health. You’ll learn why fertility is not just about getting pregnant, but about building the biological foundation that shapes a child’s brain development, metabolism, immune function, and long term resilience. This conversation reframes infertility as a meaningful signal to pause, repair, and prepare, instead of something to override or rush past. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Ann Shippy is a board-certified internal medicine physician, certified functional medicine practitioner, and a leading expert in preconception health and fertility optimization. A former IBM chemical engineer, she brings a rare systems-based and data-driven approach to uncovering the root causes of infertility, chronic disease, and hormonal dysfunction. Through her Austin-based medical practice, she has helped men and women restore fertility naturally and conceive healthy children well into their 40s using advanced lab testing, precision supplements, and targeted functional medicine strategies. Together, Dave Asprey and Dr. Shippy explore why childhood illness and infertility are rising at the same time, and how environmental toxins, mold exposure, microbiome imbalances, sleep disruption, and chronic inflammation undermine fertility in both men and women. They discuss the role of mitochondria, circadian rhythms, thyroid health, testosterone, and epigenetics in reproductive health, and why IVF should not be the first step without addressing underlying biological dysfunction. You’ll Learn: • Why preconception matters more than pregnancy for long term child health • How sperm and egg quality act as biological time capsules for future generations • Why infertility functions as a warning signal instead of a random failure • How environmental toxins and mold exposure disrupt fertility and mitochondrial health • The connection between fertility, longevity, and overall human performance • Why sleep, circadian rhythm, and stress strongly influence reproductive hormones • The role of thyroid function and testosterone in fertility and metabolism • When IVF makes sense and why it should not bypass foundational health work Thank you to our sponsors! - Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: preconception health, fertility optimization, healthy pregnancy preparation, sperm and egg quality, epigenetic inheritance, generational health, infertility root causes, environmental toxins fertility, mitochondrial health fertility, functional medicine fertility, hormone balance fertility, IVF alternatives, natural fertility strategies, longevity and reproduction, human performance biology, sleep and fertility, circadian rhythm health, supplements for fertility, smarter not harder health, Dave Asprey fertility, Human Upgrade fertility, Dr. Ann Shippy, Ann Shippy MD, Ann Shippy fertility expert, Ann Shippy preconception, The Preconception Revolution Resources: • Dr Shippy’s New Book ‘The Preconception Revolution’: https://annshippymd.com/the-preconception-revolution/ • Dr Shippy’s Website: https://annshippymd.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:45 — Introduction 2:49 — Rising Childhood Illnesses 5:47 — Ann’s Fertility Journey 10:41 — Environmental Toxins & Mold 12:42 — Circadian Rhythms & Sleep 16:42 — IVF Considerations 19:54 — Infertility as a Warning Sign 22:20 — Egg Selection & Biology 26:43 — Men’s Role in Fertility 28:16 — Supplements for Fertility 36:49 — Thyroid & Fertility 42:20 — Testosterone & Fertility 50:40 — Stress & Trauma 53:56 — Spiritual Aspects 59:15 — Relationship Health

Try TrueDark Glasses: https://truedark.com/?coupon-code=DAVETUBE&sc-page=shop Kill your zombie cells with: http://www.qualialife.com/davenad Your brain has a built-in switch that controls deep sleep but for most people, it’s turned off. In this video, Dave Asprey exposes the hidden factors blocking your deep sleep. He shows how small changes to posture, meal timing, and lighting can reactivate your brain’s sleep control center so you sleep deeper, recover faster, and wake up refreshed, all in 6.5 hours a night. *** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. *** Thank you to our sponsors! • ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. • AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. Timestamps 00:00 – The Hidden Sleep Switch Nobody Talks About 01:35 – The Root Causes of Bad Sleep 02:13 – The Invisible Force Ruining Your Sleep 03:48 – The Worst Sleeping Positions (and Why) 04:30 – Correct Setup for Side and Back Sleepers 06:23 – Why Food Timing Destroys Deep Sleep 08:29 – The 3-Hour Rule 09:33 – The Circadian Rhythm Problem in Modern Life 11:30 – The Brain’s Master Clock 12:30 – Mimicking Nature with Morning and Evening Light 14:20 – Proof That Light Manipulation Works 15:05 – How to Reset Your Circadian Rhythm Step-by-Step Resources:   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com   • Upgrade Labs: https://upgradelabs.com   • 40 Years of Zen: https://40yearsofzen.com  Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast:  Instagram: https://www.instagram.com/TheHumanUpgradePodcast/  Facebook: https://m.facebook.com/Thehumanupgrade/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode shows how entrepreneur Jonathan Swanson uses world class delegation and human plus AI support to reclaim time, reduce stress, and create the personal leverage needed for better health, clearer thinking, and a more ambitious life.

Host Dave Asprey and Jawzrsize founder Brandon Harris reveal how targeted jaw training improves posture, airway function, cognitive performance, and facial strength by restoring the full range power modern diets no longer provide.

This episode reveals how focused ultrasound can directly stimulate the vagus nerve to shift the body out of chronic sympathetic stress, improve HRV, support emotional regulation, and build long term autonomic resilience through daily nervous system training.

Dave Asprey breaks down what really happens during a 72-hour fast, showing how deep cellular repair, autophagy, and mitochondrial rejuvenation activate only in the later stages of fasting and how to prepare, fast, and refeed safely for the strongest anti-aging results.

Host Dave Asprey and Dr. Nayan Patel reveal how advanced transdermal delivery of glutathione, GHK copper peptide, and vitamin C can rapidly rebuild collagen, restore intracellular copper, improve hair and skin density, and upgrade the biology of aging from the inside out.

This episode reveals how BioHarvest’s plant cell technology creates highly bioavailable compounds like piceid resveratrol without growing the plant, delivering measurable improvements in blood flow, brain performance, and longevity while eliminating the waste and inconsistency of traditional extraction.

This episode explores how Raffaele Gianfrancesco uses vibroacoustics, flickering light, and harmonic frequency technology to rapidly shift brain states, release stored trauma, and create deep coherence in the mind and body.

This episode tells the true story of how a burned out Silicon Valley millionaire discovered a simple Tibetan drink that transformed his energy, rewrote the science of fat and metabolism, and sparked a global movement that changed how the world eats and performs.

This episode reveals how whole body vibration unlocks rapid circulation, lymphatic drainage, balance, and nitric oxide activation, giving you many of the benefits of a full workout while you stand still.

In this episode, Dave Asprey and Dr. Cameron Chesnut reveal how cutting edge anesthesia protocols, regenerative fat transfer, metabolic prep, peptides, ketones, hyperbarics, and non opioid pain strategies can transform any surgical procedure into a safer, faster healing, brain protected experience with dramatically improved long term results.