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The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
1421 episodes
1 day ago

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Show more...
Health & Fitness
Education,
Self-Improvement,
Science
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All content for The Human Upgrade: Biohacking for Longevity & Performance is the property of Dave Asprey and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Show more...
Health & Fitness
Education,
Self-Improvement,
Science
Episodes (20/1421)
The Human Upgrade: Biohacking for Longevity & Performance
The Tiny Implant Replacing Life-Changing Drugs | Biohacking Tools : 1365
Host Dave Asprey and Dr. Kevin J. Tracey reveal how targeted vagus nerve stimulation can control inflammation, replace drugs, and unlock powerful upgrades in immunity, metabolism, brain performance, and longevity through bioelectronic medicine.
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1 day ago
56 minutes 4 seconds

The Human Upgrade: Biohacking for Longevity & Performance
The Boring Secret Behind Celebrities Who Don’t Age : 1364
This episode reveals how lobsters, telomeres, and a little-known enzyme point to a surprising anti-aging pathway you can activate in just ten minutes a day through simple, evidence-backed practices that help slow cellular aging.
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3 days ago
14 minutes 50 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Biohacking News Weekly Update : 1363
This week's biohacking roundup covers five major breakthroughs: cocoa extract reducing cardiovascular deaths by 27%, FDA-cleared AI stethoscopes for home health monitoring, the explosive rise of beef organ supplements among women, spirulina's renewed spotlight for longevity and collagen support, and new Senate legislation to protect health data from wearables and wellness apps.
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5 days ago
10 minutes

The Human Upgrade: Biohacking for Longevity & Performance
How to Build Muscle WITHOUT Lifting! Biohacker Longevity : 1362
Host Dave Asprey talks with Dr. Sten Stray-Gundersen to reveal how blood flow restriction and intermittent hypoxia training unlock faster strength, hormone, and longevity gains by optimizing oxygen use, vascular health, and mitochondrial performance with minimal effort.
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6 days ago
1 hour 3 minutes 49 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Why Motivation DOESN’T Work | Mental Biohacks : 1361
Host Dave Asprey talks with personal growth leader David Bayer to reveal why motivation fails, how belief and perception shape reality, and how rewiring the mind through awareness, forgiveness, and consciousness can unlock lasting transformation, resilience, and human performance.
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1 week ago
39 minutes 28 seconds

The Human Upgrade: Biohacking for Longevity & Performance
New Japanese Walking Hack Burns More Fat Than 10,000 Steps : 1360
Dave Asprey reveals a powerful Japanese walking method that burns fat faster than 10,000 steps, lowers stress, boosts mitochondrial health, and transforms metabolism in just 15–30 minutes a day.
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1 week ago
9 minutes 22 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Biohacking News Weekly Update : 1359
Dave Asprey breaks down six new breakthroughs in biohacking and health tech—from melatonin’s hidden heart risks to mitochondrial immune upgrades, AI that decodes cells, and a first-ever blood test for chronic fatigue—giving you the data you need to live longer, think faster, and perform at your peak.
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1 week ago
11 minutes 39 seconds

The Human Upgrade: Biohacking for Longevity & Performance
The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358
Dr. Daniel Amen joins Dave Asprey to explain how emotional and physical pain share brain circuits, what 300,000 scans reveal about trauma, toxins, and thought patterns, and how tools like havening, rage journaling, red light, and saffron retrain the brain for relief.
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1 week ago
1 hour 8 seconds

The Human Upgrade: Biohacking for Longevity & Performance
The New SCIENCE of Energy Healing | Biohacking Updated : 1357
After being bedridden for seven years, Harry Massey discovered the power of bioenergetic healing and developed the GEM wearable—an energy-based device designed to activate over a thousand genes linked to cellular repair, mitochondrial efficiency, and longevity.
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2 weeks ago
37 minutes 16 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356
Host Dave Asprey reveals why aging isn’t determined by time but by the health of your cells—showing how to measure your true biological age, strengthen your mitochondria, and use fasting, REHIT workouts, and stress-resilience hacks to feel younger, stronger, and more focused at any age
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2 weeks ago
21 minutes 52 seconds

The Human Upgrade: Biohacking for Longevity & Performance
What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355
Host Dave Asprey and Leela Quantum Tech founder Philipp Samor von Holtzendorff-Fehling explore how quantum energy and frequency medicine can neutralize EMFs, enhance mitochondrial performance, and unlock a new frontier in human performance, longevity, and consciousness.
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2 weeks ago
45 minutes 24 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354
Dave Asprey and Dr. Rollin McCraty explore how heart rate variability and coherence training unlock peak performance, emotional balance, and the hidden connection between your heart, brain, and consciousness.
Show more...
2 weeks ago
1 hour 10 minutes 18 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Biohacking Cannabis: The DNA Science of Plant Medicine : 1353
Host Dave Asprey and EndoDNA founder Len May reveal how decoding your DNA can personalize cannabis, psychedelics, and supplements to enhance brain performance, longevity, and overall human optimization.
Show more...
3 weeks ago
43 minutes 13 seconds

The Human Upgrade: Biohacking for Longevity & Performance
This Legal Focus Powder Beats Any Dopamine Detox : 1352
Dopamine isn’t your real problem — low brain energy is. In this solo episode, Dave Asprey reveals how fatigue in your mitochondria, not dopamine addiction, is what’s draining your focus and motivation — and explains how creatine, the overlooked brain energy molecule, can rapidly recharge your ATP, sharpen cognition, and restore your mental performance in just minutes a day.
Show more...
3 weeks ago
18 minutes 27 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Biohacking News Weekly Update : 1351
Dave Asprey breaks down five breakthrough stories in biohacking and health-tech — from vitamin D’s anti-aging power to gene-based rejuvenation, gut-driven autophagy, supplement reform, and the rise of AI-powered medical avatars reshaping the future of personalized health.
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3 weeks ago
5 minutes 57 seconds

The Human Upgrade: Biohacking for Longevity & Performance
How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350
Host Dave Asprey reveals how to safely use nicotine as a potent nootropic and longevity tool—exploring dosage, genetics, stacking, and biohacking strategies to enhance focus, metabolism, and mitochondrial performance without addiction.
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3 weeks ago
34 minutes 28 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Why Women’s Joints Are Failing 10x Faster : 1349
Kiran Krishnan reveals how joint degeneration is driven by inflammatory cytokines and poor circulation—and shares breakthrough strategies using nutrition, mitochondrial support, and clinical research to reverse arthritis, rebuild cartilage, and slow biological aging.
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4 weeks ago
57 minutes 16 seconds

The Human Upgrade: Biohacking for Longevity & Performance
Why You Still Feel Tired And Foggy On A Perfect Diet : 1348
This episode reveals the hidden biological disruptors—like EMFs, mold, and toxins—that sabotage your energy, focus, and longevity, even when your diet is perfect, and shows you how to eliminate them for truly lasting upgrades.
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1 month ago
12 minutes 36 seconds

The Human Upgrade: Biohacking for Longevity & Performance
10 Minute Weekly Biohacking Update : 1347
This episode delivers five cutting-edge biohacking breakthroughs—from AI heart scans to brain training and digital twins—plus a five-day protocol to upgrade your biology with real science, not guesswork.
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1 month ago
6 minutes 1 second

The Human Upgrade: Biohacking for Longevity & Performance
These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346
Host Dave Asprey and medical anthropologist Alberto Villoldo, Ph.D., explore how ancient plant medicine, mindset, and modern biohacking can regenerate the brain, activate healing genes, and unlock higher human performance.
Show more...
1 month ago
56 minutes 52 seconds

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.