My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
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In this video I do a full deep dive on injectable L-carnitine—what it is, how it actually works in your body, and how I personally use it in my own optimization routine. I’ve been using injectable L-carnitine for years, and the longer I use it, the more it’s become one of those quiet, reliable staples I always come back to for energy, performance, and longevity support.
I start by breaking down the basics: L-carnitine is a naturally occurring amino acid derivative that shuttles long-chain fatty acids into the mitochondria so they can be burned for energy. When you think L-carnitine, think mitochondria, ATP, and better fuel utilization. I explain why injectable L-carnitine is so powerful compared to oral—much higher bioavailability, higher plasma levels, and you avoid some of the downsides like elevated TMAO that can show up with long-term, high-dose oral use.
From there, I walk through the human data: improved exercise performance, reduced lactate, better recovery, cardiovascular support, and even a wild study in centenarians showing more muscle, less fat, and better physical function from L-carnitine supplementation. I also talk about cognitive and mood benefits, and why I stack injectable L-carnitine with acetyl-L-carnitine orally for brain health.
I’m honest about side effects and trade-offs: post-injection pain, occasional lumps, and even the “fishy odor” some people notice at higher doses. I share exactly how I dose it (usually 400–500 mg IM before workouts, three to four times per week), why I prefer intramuscular over subcutaneous, and what needle size works best in the real world.
I close by making the case that injectable L-carnitine isn’t a magic fat burner—but it is one of the most useful, versatile tools for anyone who cares about performance, energy, and long-term health.
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In this video, I delve into the intricate relationship between testosterone therapy and mental health in both men and women. Drawing from extensive research and personal experience, I discuss how low testosterone levels can affect mood, energy, and cognitive functions, leading to issues like depression and anxiety. While testosterone therapy is not a cure-all, it can significantly alleviate certain mental health symptoms by optimizing hormone levels. I also address common misconceptions about testosterone therapy, such as the myth of 'roid rage,' and emphasize the need for a comprehensive approach to mental health that includes physical, emotional, psychological, and spiritual components. Additionally, I touch upon the importance of monitoring testosterone levels as a potential factor in mental health issues and offer insights into the impact of testosterone on cognitive improvement and mood stability, especially in hypogonadal individuals.
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In this episode, I break down one of the most confusing topics in the entire peptide world — the difference between GHRHs (growth hormone–releasing hormones) and GHRPs (growth hormone–releasing peptides). I know a lot of people get tripped up by this, especially with so many companies selling blends that mix multiple GH peptides together. So I wanted to simplify it and show you exactly how these compounds work, what makes them different, and how to use them intelligently to get the best results.
I’ll walk you through how each class — GHRHs like CJC-1295 and Tesamorelin, and GHRPs like Ipamorelin and GHRP-6 — activates unique pathways in the body. You’ll learn why stacking them correctly can amplify growth hormone release far beyond what either can do alone, and why combining the wrong ones is often redundant or even counterproductive.
Whether you’re brand new to peptides or have been experimenting for years, this episode will give you a clear framework for how to structure your peptide stack for anti-aging, better recovery, improved sleep, and optimized body composition. I’ll also share my personal experience, what I’ve seen work best for clients, and how to avoid the common mistakes people make when using growth hormone–based peptides.
If you’ve ever wondered how to pair CJC with Ipamorelin, when Tesamorelin makes sense, or what the real differences are between these compounds, this episode will give you all the answers — straight from my experience and research in the field.
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In this episode, I dive deep into what I believe could be the most powerful synergy in the entire world of longevity and metabolic optimization — the combination of SGLT2 inhibitors (like Jardiance and Farxiga) with GLP-1 agonists (like Retatrutide, Tirzepatide, and Semaglutide).
These medications were originally created for diabetics, but what we’re learning now is that they may be rewriting the entire playbook on healthspan and lifespan extension. I break down the research showing how SGLT2 inhibitors not only lower blood glucose but also improve cardiovascular health, protect the kidneys, reduce inflammation, and even clear senescent cells — all while mimicking the effects of caloric restriction and fasting.
Then, I explain how pairing them with a GLP-1 creates a metabolic symphony unlike anything else we’ve ever seen. Together, they reduce insulin resistance, improve energy metabolism, and activate the same longevity pathways linked to caloric restriction, AMPK activation, and mitochondrial renewal.
If you care about living longer, staying leaner, and protecting every organ system in your body, this episode is a must-listen. I share what I’ve seen personally, what’s happening in clinical data, and why I believe the GLP-1 + SGLT2 combo could end up being one of the greatest discoveries in modern medicine for both health and performance.
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In this episode, I dive deep into one of my all-time favorite immune-support peptides — Thymosin Alpha 1 (TA-1).
As we head into cold and flu season, I wanted to do a full recap and update on why TA-1 is something I always keep in my own stack. It’s one of those foundational peptides that a lot of people overlook once they move on to “sexier” compounds, but the truth is — few things strengthen the immune system, fight inflammation, and restore balance like this one does.
I’ll walk you through:
What Thymosin Alpha 1 actually is and how it was discovered
How it works in the body to activate T-cells, natural killer cells, and the innate immune system
Its antiviral, anti-tumor, and anti-inflammatory effects backed by global clinical studies
Why it’s FDA-designated for certain cancers and used in over 35 countries for immune-related diseases
The real-world dosing strategies I use for immune maintenance, illness prevention, and recovery
How TA-1 synergizes with glutathione and other immune peptides
And why it’s an absolute must-have during stressful periods, travel, or any time your system feels run-down
I also share some of the newer data around TA-1’s role in cancer therapy, viral infections, and immune modulation — and why it continues to be one of the safest, most versatile peptides out there.
If you’re someone who wants to stay strong, resilient, and protected year-round without relying on the usual over-the-counter stuff, this episode is for you.
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In this video, I dive deep into one of the most important concepts for the future of health optimization — Peptide Replacement Therapy (PRT). Just like we replace hormones as we age, it’s time to start replacing the endogenous peptides that naturally decline over time and are critical to maintaining energy, muscle, immunity, and longevity.
I walk through 14 naturally occurring peptides — like IGF-1, Thymosin Alpha 1, TB-500, KPV, MOTS-C, Humanin, SS-31, Glutathione, Epitalon, Kisspeptin, Oxytocin, GHK-Cu, and others — explaining what they do, how they decline with age, and how we can safely and effectively use peptide analogs to restore youthful balance and optimize the aging process.
If you’re already optimizing hormones, this is the next frontier in extending healthspan and performance — Peptide Replacement Therapy.
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In this video I break down pregnenolone for men on testosterone therapy and share when it helps, when it does nothing, and when it can backfire. We cover the steroidogenesis pathway so you can see where pregnenolone sits as the mother hormone. I explain how TRT suppresses LH and FSH and why that can lower testicular production of upstream steroids even if adrenal output is unchanged. I walk through pregnenolone’s role as a neurosteroid, how it converts to allopregnanolone, and why that often improves sleep quality, stress tolerance, and mood via GABA modulation. I also outline signs of low pregnenolone, summarize what the clinical literature suggests about cognition and anxiety, and give simple dosing guardrails I use personally and with clients. As always none of this is medical advice. Use it to have a smarter conversation with your clinician.
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In this video, I break down one of the most misunderstood topics in the GLP-1 world — microdosing Retatrutide. There’s a lot of debate online about whether you should take Retatrutide once per week or split it into multiple smaller injections. Today, I’m going deep into the science, pharmacokinetics, and real-world experience behind both approaches so you can decide what’s right for you.
I cover how microdosing affects appetite, energy, side effects, and results, and why it might be the better approach for long-term metabolic optimization. You’ll also learn how this compares to traditional weekly dosing and why both methods can work — depending on your goals.
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Creatine is one of the simplest, most proven tools for strength, brain energy, and healthy aging. In this deep dive, I explain what creatine is, how it actually powers ATP, what the human data shows for performance, cognition, recovery, and longevity, how to dose it (with or without a loading phase), common myths and side effects, and why newer forms like “creGAAtine” might help you saturate muscle and brain with less water bloat. If you’ve asked me for my baseline supplement stack, this is where I start.
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Injectable Glutathione: 2025 Update & Comprehensive GuideHey everyone, it's Hunter Williams here! In today's video, I bring you my 2025 update on glutathione, particularly injectable glutathione. I've used it for years and continue to be amazed by its benefits. This video expands on my previous content with newer clinical evidence and informed recommendations. We'll discuss its role in mitigating the effects of mitochondrial peptides, combating environmental stressors, and maintaining liver health. I'll delve into the bioavailability challenges of oral glutathione versus injectables, specific use cases like liver disease, male fertility, and even chemotherapy support. Plus, I'll share how to properly administer it, monitor its effects, and my personal insights on how it enhances energy, immune function, and overall well-being. Don't miss out on this detailed and informative guide—perfect for anyone into peptide research or looking to optimize their health! As always, check the links in the description, and don't forget to join my email list for updates. Thanks for your continuous support. Let's dive in!00:00 Introduction and Video Overview
02:39 What is Glutathione?
03:47 Bioavailability and Delivery Methods
06:06 Mechanisms of Action and Benefits
08:41 Clinical Applications and Case Studies
25:27 Dosing Guidelines and Best Practices
28:48 Conclusion and Final Thoughts
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Timestamps
00:00 Introduction and Video Overview00:14 Oxytocin and Its Connection to Fat Loss01:16 Scientific Data and Research on Oxytocin02:30 Mechanisms of Oxytocin in Fat Loss04:23 Oxytocin's Effects on Appetite and Metabolism05:29 Comparing Oxytocin with Other Weight Loss Aids10:37 Direct Actions of Oxytocin on Fat Cells11:59 Animal and Human Studies on Oxytocin19:26 Oxytocin Usage Protocols24:33 Potential Side Effects and Safety26:56 Conclusion and Final ThoughtsJoin me, Hunter Williams, as I delve into the fascinating connection between oxytocin—the 'love hormone'—and its surprising benefits for fat loss. Discover the scientific data and practical insights that show how this peptide hormone can enhance muscle preservation, improve metabolism, and reduce cravings for high-fat foods. Learn the optimal ways to use oxytocin, including dosing protocols and the synergy with diet and exercise. Don't forget to stay connected by joining my email list for updates on new videos and content. Let's dive in and explore how oxytocin can support your fitness and wellness journey!
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Timestamps
00:00 Introduction and Q&A Overview
01:39 First Question: CJC 1295 Dosage
02:20 Retatrutide with HCG Monotherapy
03:04 Peptides for Relaxation and PTSD
03:49 Peptides for Migraines
04:22 Combining GLP-1 and Tesamorelin
04:51 Workout Timing and Peptide Injections
06:08 Dealing with GLP-1 Fatigue
07:54 GLP-1 for Autoimmune Diseases
09:22 Peptides for Cold, Flu, and COVID-19
09:55 Peptides for Energy and Overall Health
10:39 Testing Peptides Separately vs. Blends
13:16 Metformin and Biomarker Testing
14:18 Body Recomposition and Peptides
15:07 Peptides for Tendinitis and Pain Management
16:18 Muscle Building Peptides
17:25 Metformin and Protein Synthesis
18:07 Thoughts on SARMs
19:16 Enclomiphene for Testosterone Production
20:25 Injectable Bioregulators
22:48 Peptides for Heart Health
23:30 Peptides for Lung Issues
25:40 Peptides for Hair Growth
30:12 Shipping Peptides in Summer Heat
31:08 Testosterone for Women
31:34 Bio Regulators for All Ages
31:53 Metformin and Jardiance: A Powerful Combo
32:22 Peptides for Histamine and Inflammation
32:54 Reconstituting Peptides: Tips and Tricks
34:31 Stacking Peptides: Safety and Recommendations
34:56 Comparing Metformin and ATX 304
36:02 Combining Peptides for Appetite and Weight Management
36:44 Titrating Off Tirzepatide
38:33 Understanding Blood Sugar and Insulin
40:37 Testosterone Therapy and Hair Loss
41:22 Peptides for Joint Pain and Recovery
42:19 Peptides for Lung Health
42:53 Peptides for Fat Loss in Athletes
43:42 Synthetic vs. Natural BioRegulators
44:21 Peptides and Gene Mutations
45:53 Testosterone Levels in Women
46:26 GLP Drugs for Weight Loss
47:02 Peptides for Perimenopausal Women
47:47 Stacking Tirzepatide and Retatrutide
48:29 Daily Timing of Peptides and Supplements
50:39 Combining Peptides in One Syringe
51:19 Peptides for Bladder Infections
51:54 Muscle Growth with Retatrutide
53:47 Peptides for Older Adults
54:40 Hormone Imbalance in Women Over 55
55:13 Peptides for Pets
56:43 Supplements with TRT
57:27 Evaluating Sermorelin
58:55 Dealing with Peptide-Induced Cramping
01:00:06 Final Thoughts and Appreciation
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00:00 Introduction and Video Overview
00:20 Personal Experience with SS 31
01:43 Scientific Basis and Human Trials
03:25 Mechanisms of SS 31
07:37 Clinical Applications and Benefits
14:46 Dosing Guidelines and Safety
21:21 Emerging Applications and Future Potential
26:51 Conclusion and Final Thoughts
In this comprehensive deep dive into SS-31, I'll be sharing my personal experience with this powerful mitochondrial peptide, its scientific mechanisms, clinical applications, dosing guidelines, and the outstanding benefits observed in various human trials.
Whether you're looking to enhance your energy levels, improve athletic performance, or support your cardiovascular and cognitive health, SS-31 offers promising solutions. Don't miss out on this essential biohacking tool!
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I break down the human data on HGH (human growth hormone) for anti-aging and performance—what actually improves, what doesn’t, and where it clearly helps (injury recovery and true GH deficiency). I also cover side effects, dosing philosophy (“replacement, not enhancement”), and how to think about HGH in a longevity stack as you age.
Timestamps
0:00 - Intro, goal of the video and who this is for
2:10 - What HGH is and age-related decline (somatotropin refresher)
3:28 - The Rudman 1990 study and “turning back the clock” claims
4:26 - 1994–1996 trials: lean mass up, strength/endurance unchanged
5:00 - 2002 Blackman RCT + meta-analysis: +2 kg lean, −2 kg fat
7:00 - Side effects: edema, joint pain, carpal tunnel, insulin resistance (dose-dependent)
8:38 - Athletic performance evidence: banned in sport, but does it help?
10:06 - WADA/Stanford findings: sprint bump, no strength/endurance gains
12:20 - Injury & healing overview: why HGH could help tissue repair
12:36 - Burn-healing data: faster closure and shorter stays (with hyperglycemia risk)
13:48 - Fracture healing: tibial fracture RCT, closed vs. open outcomes
15:28 - ACL surgery study: better knee extensor strength without bigger muscles
17:02 - Adult GH deficiency (AGHD): signs, causes, quality-of-life impact
18:48 - Early AGHD trials (1989–1990): composition, VO₂, well-being improvements
19:40 - 2000s–today: cardio risk markers, aerobic capacity, long-term outcomes
20:34 - Who benefits most: AGHD/older adults vs healthy/athletes
25:08 - Replacement vs enhancement: practical dosing philosophy
26:00 - Final verdict: where HGH fits in a longevity stack
27:14 - New studio, channel update, and closing thoughts
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In today’s video I unpack amlexanox—an old anti-inflammatory/allergy drug with surprising metabolic effects. I share my first encounter with it in the research-chem world, what I noticed subjectively, and then dive into mechanisms (IKKε/TBK1 inhibition, catecholamine resensitization, beige fat), rodent data, the Phase 2 human trial (150 mg/day), safety, dosing, who seems to respond best, and how I’m stacking it inside Bio Ignite. If your goal is fat loss with stubborn adipose inflammation, this is worth understanding.
0:00 - Welcome + what today’s video covers
0:28 - How I first found “AM Lox” browsing catalogs
1:06 - Cycling off SLU-PP-332 and first personal trial
1:40 - Noticing dryness/ab definition; early under-dosing
2:12 - 2025 “sugar diet” + hunting for FGF21 boosters
2:40 - Finding data that amlexanox increases FGF21
3:02 - Literature dosage (100–150 mg) vs my early dose
3:38 - Why I think it’s a useful fat-loss rotation tool
4:24 - Channel/hosting update + where to find my videos
5:08 - Slides start: what amlexanox is/was used for
6:00 - Core mechanism: IKKε/TBK1 → PDE3B → cAMP resistance
7:16 - IL-6→STAT3 hepatic signaling + beigeing via FGF21
8:30 - Big-picture benefits: inflammation, insulin sensitivity, glycemia
10:32 - Human data: Phase 2 trial (150 mg/day x 12 weeks)
11:10 - Modest/variable weight change; who improved most
12:37 - Practical takeaways: glycemia, liver fat, insulin sensitivity
14:12 - Dosing in practice (50 mg caps, TID = 150 mg/day)
15:12 - Responder phenotype: high adipose inflammation
16:00 - Who benefits most + variability at similar body fat
17:56 - Study roll-up and mechanism recap
18:52 - Final thoughts, use-cases, and product note (Bio Ignite)
19:54 - Thank you + where to grab the peptide cheat sheet
What You'll Learn
Why amlexanox can “release the brakes” on fat-burning by inhibiting IKKε/TBK1 and restoring cAMP/catecholamine responsiveness.
How it raises IL-6 transiently in adipose, activates STAT3 in the liver, suppresses gluconeogenesis, and increases FGF21 to promote beige fat programs.
The mouse vs. human gap: robust fat loss in mice; in humans, clearer improvements in A1c, fructosamine, liver fat, insulin sensitivity—especially when adipose inflammation is high.
Dosing used in the Phase 2 trial: 50 mg TID (total 150 mg/day) for 12 weeks.
Safety snapshot: no serious AEs attributed to amlexanox in metabolic trials; most common was a transient rash.
Timestamps (exact to the transcript)What you’ll learn
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In this 2025 refresh I walk through why GHK-Cu remains one of the most versatile, well-tolerated peptides for systemic repair and cosmetic wins. I cover mechanisms (copper delivery + gene modulation), data across tissues (skin, bone, liver, lung, gut, nerves), and performance/brain angles (sleep loss resilience, anxiolysis, analgesia).
I also talk realistic use cases, stacking concepts, and where the research is heading—plus how I’m rebuilding after my original channel was deleted.
If this helped, drop a comment and make sure you’re on my email list so we can stay connected no matter what platforms do next.
0:00 - Intro, channel update & why I’m revisiting GHK-Cu
3:09 - What is GHK-Cu? Discovery, decline with age & why it still matters
4:46 - Core mechanisms: copper delivery + gene-expression “reset”
9:50 - Wound healing fundamentals (closure, granulation, angiogenesis)
11:06 - Systemic healing even under steroids (cortisone models)
13:00 - Organ regeneration: liver “youth,” COPD gene signature, gut lining
14:18 - Ulcerative colitis 2025 study: cytokines down, barrier up
17:10 - Skin rejuvenation: collagen, firmness, pigmentation
18:20 - Hair growth: anagen extension, minoxidil-level results
22:08 - Practical stacks, safety notes & key takeaways
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In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you’ve heard ATX-304 described as “exercise in a capsule,” you’ll see why after going through the research, mechanisms, human trials, and potential applications.
I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.
👉 Don’t forget to download the Peptide Cheat Sheet linked below and join my email list for updates on cutting-edge research compounds.
⏱️ Timestamps
0:00 – Intro & what ATX-304 is
0:27 – Why it’s also called OS-01/OS-03
1:06 – Clearing up confusion with skincare OS-01
1:21 – Background & how I discovered ATX-304
2:15 – Why early adoption is expensive & my mission to lower costs
3:00 – What makes ATX-304 different from other mitochondrial supplements
3:14 – Mechanisms, animal trials, human data & dosage overview
4:13 – Discovery & development background (Sweden to Cambrian Biotech)
5:07 – Phase 2 trials in type 2 diabetes (glucose & vascular effects)
6:00 – AMPK explained in simple terms
7:11 – Mechanism of action: preventing dephosphorylation
8:34 – ATX-304 as a dual AMPK + mitochondrial activator
9:34 – Effects on glucose metabolism & insulin sensitivity
10:24 – Why fasting insulin improvements matter
10:42 – Lipid metabolism, fatty liver benefits & cholesterol reduction
12:15 – Fat mass reduction with muscle preservation
13:00 – Why this matters for body composition vs. GLP-1s
14:04 – Cellular stress response & autophagy benefits
15:00 – Vascular and cardiac improvements
16:16 – Diabetes studies: preventing disease progression
17:18 – Anti-aging effects in mice (exercise capacity & insulin sensitivity)
18:02 – Liver protection benefits
18:25 – Kidney protection against toxic injury
19:12 – Vascular disease, aneurysm & neurodegeneration studies
20:06 – Preclinical evidence across multiple organ systems
20:10 – Human trial: 28-day study results
21:04 – Safety profile & side effect comparison to GLP-1s
22:00 – Clinical development & obesity trials
22:18 – Potential in combination with semaglutide
23:00 – Dosage ranges (100–1000mg) & cost considerations
24:14 – Why it reduces insulin burden & cardiovascular risk factors
25:00 – Sustainable fat loss & improved exercise capacity
26:44 – Vascular protection & fatty liver disease applications
27:25 – Neurodegeneration & concussion recovery potential
27:58 – Healthy aging & safety considerations
28:38 – Summary: exercise in a bottle & proven benefits
29:23 – Closing thoughts, gratitude & community message
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0:00 - Intro: why I’m covering Testagen
0:30 - The low-T epidemic and TRT context
1:12 - Why I’m excited about Testagen vs HCG
2:00 - What I’ll cover today (what it does, dosing, use cases)
2:40 - What Testagen is (KEDG bioregulator peptide)
3:12 - Mechanisms and “does this help women?” note
4:00 - Core effects: endocrine support + epigenetic action
5:00 - Target tissues: pituitary, thyroid, testes, bone marrow
6:00 - Vascular/erectile benefits; “calibrating” the HPT axis
6:30 - Fertility use case + my personal plan
7:16 - Manufacturer indications; sexual function improvements
8:12 - Case study: semen parameters quadrupled on Testolutin
8:58 - Thyroid support, TBI/central hypo considerations
9:58 - Anti-aging & immune modulation overview
10:20 - Human evidence: oral Testolutin study (TT, LH/FSH ↑)
11:02 - Human evidence: IM Testagen (2.5 mg x 10 days) results
11:48 - 2022 combo study (4-peptide stack; free T ↑ ~54%)
13:08 - Animal data: pituitary-independent thyroid restoration
14:08 - Cell data: nuclear entry, histone/DNA binding
14:34 - Outcomes summary: testosterone, LH/FSH, libido
15:02 - Testagen vs TRT; stacking with Epitalon/Epithalamin
16:01 - Safety profile: “no significant side effects” noted
16:56 - Dosing protocol I recommend (2 mg/day, 10–60 days)
17:24 - Full male-health stack ideas (Testagen + others)
17:40 - Big-picture takeaway: who benefits most
18:10 - Real-world reports, call for comments, and thanks
I break down Testagen (a KEDG bioregulator) as a legit pathway to support testicular function, HPT axis “calibration,” and fertility—without typical TRT downsides.
I walk through how it works at the epigenetic level (nuclear entry, histone/DNA interaction), human and animal evidence (oral Testolutin and injectable Testagen), thyroid and immune benefits, erectile/vascular support, and what I’ve seen in early adult men with low T.
I also share my fertility plan, practical dosing (2 mg/day; 10–60 days), and how I’d pair Testagen with peptides like Epitalon, Libidon, Glandokort, and Superfort for broader rejuvenation. If you’ve used Testagen, drop your experience—wins or misses—so we can help the community learn what’s working.
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