My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
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In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you’ve heard ATX-304 described as “exercise in a capsule,” you’ll see why after going through the research, mechanisms, human trials, and potential applications.
I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.
👉 Don’t forget to download the Peptide Cheat Sheet linked below and join my email list for updates on cutting-edge research compounds.
⏱️ Timestamps
0:00 – Intro & what ATX-304 is
0:27 – Why it’s also called OS-01/OS-03
1:06 – Clearing up confusion with skincare OS-01
1:21 – Background & how I discovered ATX-304
2:15 – Why early adoption is expensive & my mission to lower costs
3:00 – What makes ATX-304 different from other mitochondrial supplements
3:14 – Mechanisms, animal trials, human data & dosage overview
4:13 – Discovery & development background (Sweden to Cambrian Biotech)
5:07 – Phase 2 trials in type 2 diabetes (glucose & vascular effects)
6:00 – AMPK explained in simple terms
7:11 – Mechanism of action: preventing dephosphorylation
8:34 – ATX-304 as a dual AMPK + mitochondrial activator
9:34 – Effects on glucose metabolism & insulin sensitivity
10:24 – Why fasting insulin improvements matter
10:42 – Lipid metabolism, fatty liver benefits & cholesterol reduction
12:15 – Fat mass reduction with muscle preservation
13:00 – Why this matters for body composition vs. GLP-1s
14:04 – Cellular stress response & autophagy benefits
15:00 – Vascular and cardiac improvements
16:16 – Diabetes studies: preventing disease progression
17:18 – Anti-aging effects in mice (exercise capacity & insulin sensitivity)
18:02 – Liver protection benefits
18:25 – Kidney protection against toxic injury
19:12 – Vascular disease, aneurysm & neurodegeneration studies
20:06 – Preclinical evidence across multiple organ systems
20:10 – Human trial: 28-day study results
21:04 – Safety profile & side effect comparison to GLP-1s
22:00 – Clinical development & obesity trials
22:18 – Potential in combination with semaglutide
23:00 – Dosage ranges (100–1000mg) & cost considerations
24:14 – Why it reduces insulin burden & cardiovascular risk factors
25:00 – Sustainable fat loss & improved exercise capacity
26:44 – Vascular protection & fatty liver disease applications
27:25 – Neurodegeneration & concussion recovery potential
27:58 – Healthy aging & safety considerations
28:38 – Summary: exercise in a bottle & proven benefits
29:23 – Closing thoughts, gratitude & community message