In this episode, Prof Chapman explains how IVF protocols are adjusted for women with PCOS, why PCOS patients often respond well to IVF, and how modern stimulation and antagonist protocols have significantly reduced the risks of OHSS. He also discusses when it’s worth optimizing health before treatment, why many women with PCOS may not need IVF at all, and what makes embryo transfers slightly more complex in this group—offering reassurance and clarity for patients navigating their options.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains how advances in embryo freezing—particularly vitrification—have transformed IVF outcomes, making frozen embryo transfers just as successful as fresh transfers in many cases. He walks through the pros and cons of fresh versus frozen cycles, the original and current reasons for “freeze-all” strategies, and why factors like hormone levels, uterine environment, OHSS risk, and genetic testing all play a role in deciding the best approach. A clear, reassuring conversation to help patients understand why freezing embryos is often recommended and how the decision should be personalised.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains why implantation failure can happen even in “healthy” patients—starting with the reality that it’s common in nature too. He shares that embryo genetics are a major cause, why PGT can improve success per transfer, and what doctors check next in repeat failures (uterine shape issues, chronic endometritis, key blood tests, and certain medical conditions). He also touches on the limits of immune-based treatments and ends with an encouraging reminder that success rates improve over multiple transfers.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks the science behind endometrial receptivity—how the uterine lining changes after ovulation, what the “window of implantation” really means, and why timing is only one piece of the puzzle. He explains how tests like the ERA work, why a large trial found no improvement in pregnancy rates despite the cost, and why results can vary from one cycle to the next. Prof Chapman also weighs in on newer microbiome-based tests, and shares practical perspective on progesterone support and the risk of over-treatment in IVF and frozen embryo transfer cycles.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks the science — and the uncertainty — surrounding DHEA supplements in IVF. He explains what DHEA actually does, why androgens matter for egg development, and why older women may consider it despite mixed evidence. With practical insights, clinical experience, and a candid look at the research, he offers clear guidance on when DHEA might help, when it likely won’t, and what patients should realistically expect.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks the science behind embryo selection—what truly improves outcomes, what’s more hype than help, and why some tools may need pharmaceutical-level regulation. He explains how genetic testing compares to AI-driven selection, why non-invasive methods still fall short, and the critical role of trained embryologists in guiding success. This conversation offers a clear, evidence-based view of how couples can navigate embryo selection with confidence and realistic expectations.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman breaks down what personalized medicine truly means in the world of fertility care. He explains why tailored treatment—not “one-size-fits-all” protocols—is essential for giving patients the best chance of success. From thorough history-taking and detailed diagnostic tests, to choosing the right medications, addressing conditions like endometriosis, and avoiding unnecessary IVF cycles, he highlights how genuine individualized care works in practice.
Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains how modern genetic testing of embryos is dramatically improving IVF outcomes, even for patients in their mid-40s. He shares two remarkable recent cases of 44-year-old women who each produced a single embryo—both genetically normal—leading to unexpectedly high chances of pregnancy.
Prof Chapman also breaks down the evolving science behind embryo screening, why mutation testing in parents matters, and the promising future of non-invasive techniques using laser reflections and culture-fluid analysis.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within
the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains how embryo genetic testing has evolved over 25 years—from basic chromosome counting to today’s highly accurate methods—and what that means for IVF success rates. He breaks down the true benefits, the financial considerations, the challenges posed by mosaic embryos, and why age plays such a crucial role in deciding whether testing is worthwhile.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explores how modern medicine approaches male infertility—from identifying when genetic limitations make treatment impossible, to boosting hormone signals with medications like Clomiphene, to using direct testicular stimulation. He also explains surgical sperm retrieval for men with no sperm in the ejaculate and highlights how ICSI has transformed outcomes, allowing even very low sperm counts to achieve high fertilization rates. This clear, forward-looking walkthrough shows why most men with reduced sperm production can now expect the possibility of fatherhood.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman breaks down the key investigations behind male infertility—from assessing testicular size to detecting varicose veins and understanding why temperature plays such a crucial role in healthy sperm production. He also explains how ultrasounds, hormone tests, and genetic screening help pinpoint the root causes and guide the next steps toward effective treatment.
Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman breaks down how sperm are made—using a relatable “factory floor” analogy to explain the 90-day production process, the brain’s role as the “foreman,” and the key hormones that signal healthy spermatogenesis. He also highlights common disruptors such as stress, tumors, and especially gym supplements that can shut down sperm production in men under 30. A clear, practical look at how clinicians investigate male fertility from the top down.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman discusses the often-overlooked topic of male infertility — a challenge that affects many couples but is rarely addressed with the sensitivity it deserves. He explores the psychological impact on men, debunks common myths about sperm count and masculinity, and explains what sperm quality really means. From understanding sperm concentration, motility, and morphology to the chances of natural conception, Prof Chapman offers a grounded, compassionate look at what men can do — and why there’s still reason for optimism.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks the real science behind artificial wombs and lab-grown eggs — and why these breakthroughs are still years away from mainstream fertility clinics. He also discusses when pre-genetic testing truly makes sense, who benefits most, and how it helps couples avoid the heartbreak of failed cycles and miscarriages.
Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks one of the most common fertility questions: “What can I take to improve my egg quality?” He shares the hard truth about lifestyle factors, the limits of supplements, and why scientific evidence still lags behind online claims. From DHEAS to CoQ10, Prof Chapman separates hopeful theory from proven fact—offering clear guidance for anyone navigating fertility treatments and looking to make informed choices.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman reflects on the most remarkable breakthrough in his decades-long career — the introduction of intracytoplasmic sperm injection (ICSI) in the early 1990s. He explains how this single innovation revolutionised treatment for men with low or even absent sperm counts, making fatherhood possible where it once seemed impossible. Prof Chapman also traces the evolution of IVF success rates from just 10% in the 1980s to over 40% today, highlights the game-changing impact of embryo freezing, and discusses why global consistency in IVF ethics and regulation remains a challenge.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman talks about what happens when IVF doesn’t work — from understanding the reasons behind failed cycles to exploring next-step options like egg or sperm donation. He also shares his clinic’s success rates for women over 30, how remote and overseas patients can access treatment, and the vital role of counseling and emotional support throughout the IVF journey.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman answers a listener’s question about antiphospholipid syndrome (APAS) and how it can affect IVF outcomes. He explains how immune-related conditions increase miscarriage risk, and why treatments like heparin and steroids can improve success rates when properly managed. Prof Chapman also shares valuable insights on what to do after a failed IVF cycle—when to change protocols, consider a new clinic, or simply keep trying. His key message: don’t lose hope—persistence, proper review, and the right expertise make all the difference.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman answers viewer Jen’s two big questions about IVF costs — what happens financially if your first cycle fails, and what hidden or unexpected fees to look out for. He explains why most clinics don’t offer discounts for additional cycles, breaks down the true cost structure behind IVF treatments, and shares practical advice on what to ask before you start so you know exactly what you’re committing to.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman marks a remarkable milestone — the 500th episode of his fertility podcast. Reflecting on decades of helping couples conceive, he shares insights into one of the most common yet misunderstood fertility conditions: polycystic ovarian syndrome (PCOS). Prof Chapman explains the hormonal imbalances behind PCOS, how medications like Clomiphene and Letrozole can restore ovulation, and why many women with this condition can conceive naturally — often without IVF. A powerful, hopeful conversation grounded in science, experience, and compassion for those navigating the fertility journey.

Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF).

Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.