You’ve done it. You’ve lost the weight. But then something shifts. The hunger gets louder. Food becomes more tempting. The scale starts creeping back up. You’re doing everything right, yet your body seems to be fighting you at every turn. If this sounds familiar, you’re not alone, and more importantly, it’s not your fault.
The truth is, after weight loss, your body launches a powerful biological response designed to bring that weight back. It’s not about willpower or discipline. It’s about survival mechanisms that were built for a world without grocery stores on every corner. Understanding what’s actually happening inside your body after weight loss changes everything from how you approach maintenance to how you talk to yourself when things get hard.
Join Holly and Jim as they sit down with Dr. Paul MacLean, one of the world’s leading experts on the biology of weight regain. You’ll discover why keeping weight off requires completely different strategies than losing it, what your metabolism is really doing after weight loss, and the science-backed tools that can help you succeed long-term despite your biology working against you.
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You’ve heard it everywhere: “You can’t outrun a bad diet.” Or maybe it’s “Exercise doesn’t matter for weight loss.” Or wait, is it “Just lift weights and you’ll be fine”? The conflicting advice is enough to make anyone throw their hands up in frustration. What if the real answer isn’t choosing between diet and exercise, but understanding how they work together?
Join Holly and Jim as they sit down with Robert Ross, one of the rare researchers who has spent over three decades studying both sides of the equation. Ross is a professor in the School of Kinesiology and Health Studies at Queen’s University in Ontario, Canada, and he’s led groundbreaking research on how exercise, diet, and body fat interact, especially that stubborn visceral fat that drives metabolic disease. His work has shaped clinical guidelines and challenged long-held assumptions about weight loss. You’ll discover why the bathroom scale might be lying to you, what your belt buckle reveals that the scale doesn’t, and why being a “non-responder” to exercise might be a myth.
Get ready for a conversation that will fundamentally change how you think about managing your weight, whether you’re considering GLP-1 medications, struggling to keep weight off, or just trying to figure out if you should be doing cardio or lifting weights.
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Writing a book isn’t just about putting words on a page. It’s about translating decades of research into something that can actually change lives. After two years of late-night rewrites, deleted chapters, and countless debates over how to explain complex science in simple terms, Holly and Jim are finally ready to pull back the curtain on their new book, Losing the Weight Loss Meds.
This episode is different. Instead of diving into weight loss science, Holly and Jim are taking you behind the scenes of their creative process. You’ll hear about the “messy middle” of writing, the chapters they rewrote twenty times, and the moment they realized this book needed to exist now. More importantly, you’ll discover why weight loss maintenance, once the “opposite of sexy,” has suddenly become the most critical challenge facing millions of people.
If you’ve ever wondered what it takes to create a science-based guide that works in real life, or if you’re curious about the future of weight management in America, this conversation will give you a front-row seat to both the struggles and the breakthroughs that shaped this groundbreaking book.
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2026 is about to bring a massive surge of people starting GLP-1 medications. Maybe you're one of them. These powerful drugs can deliver incredible weight loss results, but here's what nobody talks about: starting the wrong way can cost you muscle, money, and momentum before you even get going.
Most people unknowingly sabotage their success, not because they're doing something wrong, but because no one taught them how to start smart. The difference between struggling and thriving on GLP-1s often comes down to avoiding a handful of critical mistakes in those first few weeks and months.
Join Holly and Jim as they reveal the 10 biggest mistakes people make when starting GLP-1 medications and exactly what to do instead. Whether you're about to start your first dose or helping someone else navigate their journey, this episode is your insider roadmap to setting yourself up for the best possible results and avoiding the pitfalls that derail so many others.
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Download their free guide at www.weightwisdom.com
Ever wonder why you lose weight everywhere except where you actually want to? Or why your body seems to have "favorite spots" for storing fat? It's not in your head, and it's not random.
Join Holly and Jim as they sit down with Dr. Mike Jensen, one of the world's leading experts on body fat distribution from the Mayo Clinic. His groundbreaking research has revolutionized how doctors understand fat, revealing that where your body stores it matters just as much as how much you have. You'll discover why some fat depots are actually protective while others signal metabolic trouble, and most surprisingly, what you can actually do about it.
This conversation will change how you think about your body. From the simple "pinch test" that reveals your visceral fat status to the unexpected truth about hip and thigh fat being beneficial, Dr. Jensen shares insights that could transform your approach to weight management and metabolic health.
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The holidays are here, and so is the annual tug-of-war between enjoying festive foods and dreading the scale come January. But what if you didn't have to choose? What if you could indulge in grandma's famous pie, raise a glass with loved ones, and still walk into the new year feeling great?
Join Holly and Jim as they tackle the science behind holiday weight gain and, more importantly, how to outsmart it. They're bringing in reinforcements this time: Kelly Berg and Maddison Garcia from UAB's Metabolic Kitchen share clever swaps, simple tricks, and dietitian-approved hacks that cut calories without cutting the joy. From reimagining your cocktail to rethinking your plate size, you'll walk away with strategies that actually work in the real world.
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You're doing everything right. You've been consistent with your plan, staying active, watching what you eat. But then it happens, the scale refuses to budge. For days. Then weeks. The frustration creeps in, and suddenly you're wondering if all your effort is even worth it.
Here's the truth: when your weight loss stalls, it doesn't mean you've failed. It means your body is doing exactly what it's designed to do. The plateau you're experiencing isn't a roadblock. It's actually a sign that something important is happening beneath the surface.
Join Holly and Jim as they dive into the science of weight loss plateaus. You'll discover why plateaus happen to everyone, what's really going on in your body when the scale stops moving, and most importantly, the strategic "cards" you can play to break through and keep progressing toward your goals.
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What if you could sit down with your younger self and share everything you've learned about weight loss? Not the textbook advice, but the hard-won wisdom that only comes from living it. The kind of insights that make you think, "I wish someone had told me this years ago."
Join Holly and Jim as they share powerful reflections from state-of-slimmers and listeners who've been through the journey. You'll hear honest, transformative advice about what really matters when it comes to losing weight and keeping it off. These aren't just tips, they're the truths people discovered about themselves along the way.
This episode will shift how you think about your own journey. Whether you're just starting out or looking for that missing piece, you'll find wisdom here that could change everything.
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Ever wondered why your body does strange things during weight loss, but felt too awkward to ask? You're not alone. From unexpected physical changes to confusing emotional responses, weight loss brings surprises nobody warns you about. These unspoken questions deserve genuine answers, free from judgment and shame.
Join Holly and Jim as they tackle the questions people whisper about but rarely say out loud. They're diving into the weird body stuff, the mental games, and the relationship shifts that come with losing weight. Whether it's why certain areas change first, how to handle friends who seem threatened by your progress, or feeling like a fraud when people compliment you, this episode goes there.
If you've ever had a question about weight loss that felt too personal or too embarrassing to ask, this conversation is for you. Holly and Jim bring science, compassion, and a healthy dose of vulnerability to topics most experts avoid.
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Send your awkward, embarrassing, or "too weird to ask" weight loss questions to Holly and Jim for their next episode!
The supplement aisle seems to promise everything: rapid fat burning, appetite suppression, effortless weight loss. With billions of dollars spent annually and 60% of Americans taking supplements regularly, the questions are endless. Do they actually work? Are they safe? And how do you separate the science from the marketing hype?
Join Holly and Jim as they tackle the complex world of weight loss supplements with one of the nation's leading experts. You'll discover why the supplement industry operates so differently from pharmaceuticals, what the research really says about popular ingredients, and how to make informed decisions in a marketplace flooded with big promises but limited oversight.
Their guest, Dr. Paul Coates, spent nearly two decades as director of the NIH Office of Dietary Supplements, where he guided national research priorities and consumer education. He served as president of the American Society for Nutrition and is the lead editor of the Encyclopedia of Dietary Supplements. If anyone can cut through the confusion, it's Paul.
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NIH Office of Dietary Supplements: https://ods.od.nih.gov/
You've got questions. Lots of them. And if you've been trying to lose weight or keep it off, chances are you've Googled these same burning questions at 11 p.m., desperately searching for answers that actually make sense.
From "Do I really have to give up bread?" to "What do I do when the scale isn't moving?" - these are the questions that keep showing up in Holly and Jim's clinics, programs, emails, and even chance encounters at the grocery store. The questions that make you laugh, make you think, and the ones you're probably too embarrassed to ask out loud but secretly wonder about every day.
Join Holly and Jim as they count down the top 10 most frequently asked weight loss questions, delivering science-backed answers that cut through the confusion. You'll discover why some popular beliefs might be holding you back, learn when to trust your body's signals, and find out which "golden rule" of weight loss might actually be more flexible than you think. Plus, they reveal the number one question that stumps people the most - and why the answer might completely change how you think about success.
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"I just need more willpower." If you've ever said this to yourself, you're not alone. It's one of the most common beliefs in weight loss: that success comes down to having iron-clad self-control and the ability to resist every temptation that comes your way.
But what if willpower isn't the secret weapon you think it is? What if, depending on it, is actually setting you up for failure? Holly and Jim are about to shatter one of the biggest myths in weight management and show you a completely different path to lasting success.
Join them as they reveal why willpower is overrated and share the top 10 strategies that matter far more than white-knuckling your way through cravings. You'll discover science-backed alternatives that successful people use instead of relying on mental muscle alone, and why these approaches are not only more effective, but also more sustainable for the long haul.
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I just love food too much. It's one of the most common excuses people give for not starting their weight loss journey. But what if loving food could actually be your secret weapon?
Join Holly and Jim as they welcome David Page, the Emmy-winning creator of Diners, Drive-Ins, and Dives and host of the Culinary Characters Unlocked podcast. David has built his entire career around celebrating incredible food, yet he's managed to lose over 80 pounds without sacrificing his passion for eating. His story will completely change your thinking about the relationship between food and weight loss success.
You'll discover how a diabetes scare became the catalyst for lasting change, why David chose to stay on GLP-1 medications long-term, and his brilliant strategy for transforming beloved high-calorie dishes into healthier versions that still deliver on flavor. This conversation is packed with practical tips, honest vulnerability, and proof that you don't have to choose between loving food and loving your health.
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GLP1 medications have revolutionized weight loss, helping millions achieve results they've struggled to reach for years. These powerful tools have changed the obesity treatment landscape in ways we never imagined possible. But here's what might shock you: even with these game-changing medications, many people unknowingly sabotage their own success.
The truth is, having access to effective weight loss medication is only half the battle. The other half? Knowing how to use these tools strategically and avoiding the common pitfalls that can derail your progress. Whether you're currently taking GLP1s, considering them, or planning your exit strategy, the mistakes people make are surprisingly predictable and completely preventable.
Join Holly and Jim as they reveal the 10 most critical mistakes people make with GLP1 medications. You'll discover the hidden traps that can undermine your success while you're on the medication, and the dangerous oversights that lead to rapid weight regain when you stop. This episode could be the difference between temporary results and lasting transformation.
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Fall is here, and with it comes one of the most challenging seasons for maintaining your weight loss progress. Shorter days, comfort food cravings, endless holiday gatherings, and disrupted routines create what Holly and Jim call "the perfect storm for weight gain." But what if this season didn't have to mean falling behind?
Instead of throwing in the towel until January, you can use this time to actually move forward. The science shows that people typically gain 1-3 pounds during the fall and holiday season – and most never lose it. Over five years, that's 15 pounds of creeping weight gain that could have been prevented.
Join Holly and Jim as they reveal the top 10 pitfalls that sabotage your progress during fall, along with research-backed "power plays" to counter each one. You'll discover how to fall forward instead of falling behind, setting yourself up to roll into winter ahead of the game rather than playing catch-up come January.
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Think you know everything about working out? Most people hit the gym with good intentions, but miss a critical piece of the puzzle that could be sabotaging their results. The order you do your exercises, the type of resistance training you choose, and even how you think about protein could be the difference between building functional strength and just going through the motions.
Join Holly and Jim as they welcome Professor Robin Daly from Deakin University in Melbourne, Australia. Robin holds the chair in Exercise and Aging and has made it his mission to prove that the right kind of exercise isn't just good for your muscles, it's essential for your bones, brain, and longevity. His research has been cited over 12,000 times, but more importantly, he's creating real-world programs that people actually stick with.
With the rise of GLP-1 medications causing dramatic weight loss, there's growing concern about muscle loss during the process. Robin breaks down what's really happening when people lose weight rapidly and reveals why the traditional approach to protein might be missing the mark entirely.
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When you're losing weight, you probably think about dropping dress sizes, improving blood sugar, or reducing joint pain. But what if some popular weight loss approaches could actually be setting you up for broken bones later in life? It's a connection most people never make and one that could change how you think about your weight loss journey.
This hidden risk becomes even more important as new weight loss medications help people achieve dramatic results. While losing 30+ pounds can transform your health in countless positive ways, there's a conversation happening between your bones and your weight that you've probably never heard about. The surprising truth? Even moderate weight loss of just 6-9% can significantly increase your risk for fractures.
Join Holly and Jim as they sit down with Dr. Sue Shapses, Professor of Nutritional Sciences at Rutgers University and a leading expert on the relationship between weight loss and bone health. For over 30 years, Sue has been uncovering how our weight loss strategies affect skeletal strength and long-term bone function. Her research reveals why people with obesity might have denser bones that are actually weaker and what you can do to protect yourself during weight loss.
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Ever felt like you're fighting a losing battle with hunger while trying to lose weight? You're cutting portions, counting calories, and white-knuckling your way through constant cravings. What if there was a smarter approach that didn't require superhuman willpower?
The secret isn't eating less food, it's eating differently. Today's episode introduces you to one of the most powerful yet underutilized strategies in weight management: energy density. This science-backed approach shows you how to feel completely satisfied while naturally reducing calories, using the principles of volume, water content, and food texture to work with your body's natural hunger signals instead of against them.
Join Holly and Jim as they sit down with Dr. Barbara Rolls, professor and the Helen A. Guthrie Chair in Nutritional Sciences at Penn State. Dr. Rolls literally wrote the book on this topic, Volumetrics, and has spent decades researching how we can eat more food while weighing less. Her students have gone on to become leading researchers in the field, making her insights both groundbreaking and practical for everyday life.
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You've heard the weight loss success stories, but what about the hidden cost? While the scale drops, something precious might be disappearing too – your muscle. With the rise of GLP-1 medications helping millions shed pounds rapidly, a critical question emerges: are we losing the right kind of weight?
The harsh reality is that for every pound you lose, up to 25% could be lean muscle mass. And here's the kicker – when you regain weight (which happens to most people), you don't get that muscle back. You end up at the same weight but with a completely different body composition, setting yourself up for a metabolic disaster. But there's hope, and the solution is simpler than you might think.
Join Holly and Jim as they welcome Dr. Stuart Phillips, one of the world's leading experts in muscle physiology and protein metabolism. As a distinguished university professor at McMaster University and holder of a Tier 1 Canada Research Chair in Skeletal Muscle Health, Dr. Phillips has spent decades uncovering the secrets that bodybuilders and physique competitors use to lose fat while preserving every precious gram of muscle.
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Protein is everywhere these days. Walk down any grocery aisle and you'll see "high protein" splashed across cereal boxes, snack bars, and even ice cream. Scroll through social media, and influencers are preaching about protein powder. But with all this noise, what does the science actually say about protein's role in weight management?
If you've ever wondered whether protein really lives up to the hype or if you're struggling with constant hunger, afternoon snacking, or hitting weight loss plateaus, this episode cuts through the confusion. You'll discover the research-backed truth about how much protein you actually need, when to eat it for maximum benefit, and why your breakfast might be the key to controlling your appetite all day long.
Join Holly and Jim as they sit down with Dr. Heather Leidy, one of the world's leading researchers on protein and satiety. Dr. Leidy is a nutritional physiologist and associate professor at the University of Texas at Austin who has spent two decades studying how protein impacts hunger, fullness, and eating behavior. She served on the 2020 Dietary Guidelines Advisory Committee, and her groundbreaking research focuses on the power of protein, especially at breakfast, for appetite control and weight management.
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