Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory.
Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he's turned his attention to longevity, and he's not just theorizing. Dr. Cramer is participating in Mitrix's groundbreaking mitochondrial transplantation trial, which aims to replace damaged mitochondrial DNA with healthy versions grown in bioreactors.
In this conversation, Dr. Cramer explains why he believes mitochondrial dysfunction is the root cause of aging, not just another hallmark. He discusses how energy depletion cascades into all other aging symptoms, why previous interventions like telomere extension haven't delivered, and what markers will be tracked throughout his trial. He also shares his personal longevity protocol, including rapamycin, senolytics, and hyperbaric oxygen therapy.
This is one of the first detailed discussions of autologous mitochondrial transplantation for aging in humans.
🌐Links in this video
Mitrix Bio website https://mitrix.bio
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
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Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.
Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.
The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.
Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.
This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.
🌐Links in this video
Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/38956196/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.
In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.
Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.
He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.
🌐Links in this video
Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner
X (Twitter) https://x.com/CharlesMBrenner/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.
In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.
We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.
🌐Links in this video
Dr Meikle's page at Baker https://baker.edu.au/research/staff/peter-meikle
Pelagic AI https://pelagicai.it/
Juvanescence https://juvlabs.com
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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Genetics professor Dr. Jan Vijg explains how DNA damage causes aging and why human lifespan may be limited to 115 years. Learn about the 100,000 DNA hits your cells take daily, breakthrough research on the DREAM gene complex that could slow mutation accumulation, and whether we can extend maximum lifespan.
In this conversation, Dr. Jan Vijg, Professor and Chair of Genetics at Albert Einstein College of Medicine, explains how genome instability drives the aging process. We explore how your cells sustain 100,000 DNA lesions daily, the difference between DNA damage and somatic mutations, and why mutations accumulate exponentially with age.
Dr. Vijg discusses his controversial 2016 Nature paper arguing human maximum lifespan is capped at 115 years, and why mean lifespan improvements don't translate to breaking this limit. He shares exciting new research on the DREAM gene complex - a potential master regulator that could enhance DNA repair across multiple pathways simultaneously.
Key topics include: how DNA repair systems decline with age, why long-lived species have better repair mechanisms, tissue-specific mutation rates, the role of SIRT6 and NAD in DNA repair, rare genetic variants in centenarians, and whether pharmacological interventions could slow aging at the cellular level.
🌐Links in this video
Dr Vijg's page at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/11318/jan-vijg
Evidence for a limit to human lifespan https://pubmed.ncbi.nlm.nih.gov/27706136/
The DREAM complex links somatic mutation, lifespan, and disease https://www.biorxiv.org/content/10.1101/2025.09.15.676396v1.full
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Holistic dentist Dr. Namrata Patel reveals how your oral microbiome predicts heart disease, Alzheimer's, and cancer 10-13 years before symptoms appear. Learn about saliva testing, the bacteria that cause systemic inflammation, why tongue exercises reduce sleep apnea 30%, and the daily protocol that protects your healthspan.
In this conversation, holistic dentist Dr. Namrata Patel explains how your mouth is an early warning system for chronic disease. We explore the specific bacteria that cause heart attacks, diabetes, cancer, and Alzheimer's - and how saliva testing can detect these risks years before blood tests show problems.
Dr. Patel shares breakthrough research on myofunctional therapy, showing how simple tongue exercises can reduce sleep apnea by 30%. We discuss the connection between dry mouth, nitric oxide production, and systemic inflammation, plus why conventional mouthwash may be destroying beneficial bacteria.
Key topics include: the optimal daily oral care protocol, how to monitor your oral health at home, the truth about root canals and hidden infections, when to see a functional dentist versus conventional dentist, and why oral health becomes more critical after age 40. Whether you have perfect teeth or chronic health conditions, this episode reveals how your mouth impacts your longevity.
🌐Links in this video
Green Dentistry Home Page https://sfgreendentist.com/
Dr Patel's book on Amazon:
Age With Style: Your Guide To A Youthful Smile & Healthy Living https://amzn.to/49AdQn5
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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Clinical psychologist Dr. Lloyd Glauberman reveals why smart, motivated people struggle to maintain healthy habits - and the 3 things you knew as an infant that could transform your health. Learn about lifestyle intelligence, the metabolism changes after 40, and why sustaining change is harder than starting.
In this conversation, clinical psychologist Dr. Lloyd Glauberman explains the hidden psychological barriers preventing lasting health changes. We explore how family and culture "hypnotically" program us away from natural eating, sleeping, and movement patterns we understood as infants.
Dr. Glauberman introduces the concept of Lifestyle Intelligence - managing the three core elements of health: nutrition, sleep, and exercise. He explains why metabolism slows with age, causing 20+ pound weight gain even without behavior changes, and shares practical strategies for sustaining lifestyle modifications long-term.
Key topics include: the role of sleep as the "lynchpin" for health, why perfectionism sabotages progress, how digital devices create modern trance states, and the surprising calculation showing how every meal adds or subtracts time from your life. Whether you're struggling to start or maintain health changes, this episode provides actionable psychological insights for lasting transformation.
🌐Links in this video
Lifestyle Intelligence website https://lifestyleintelligencelq.com/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Duke Professor reveals how 90-year-olds tripled their muscle strength in just 10 weeks - and why we've been measuring muscle mass wrong for decades. Dr. William Evans explains the revolutionary new test that predicts disability, mortality, and even Alzheimer's risk. Learn the exact protocols for maintaining muscle mass as you age, the truth about protein requirements, and why your doctor isn't testing for sarcopenia. Plus: critical warnings about GLP-1 weight loss drugs and muscle loss in older adults.
Dr. William Evans is a professor of medicine at Duke University whose pioneering research established sarcopenia as a recognized medical condition. In this episode, he reveals groundbreaking findings about muscle mass and aging that challenge decades of scientific assumptions.
Dr. Evans explains why traditional methods like DEXA scans have been measuring the wrong thing, and introduces his revolutionary creatine-based test that accurately measures muscle mass with just a single urine sample. His research on over 4,000 people proves that muscle mass is central to how we age - affecting everything from physical disability to cognitive function and mortality risk.
We discuss practical strategies for maintaining muscle, including resistance training protocols, optimal protein intake for older adults, and the concerning effects of GLP-1 weight loss drugs on muscle preservation. Dr. Evans also shares insights on hormone therapy, the future of muscle-building drugs, and why exercise remains the single most important intervention for healthy aging and Alzheimer's prevention.
🌐Links in this video
Dr Evans page at Duke University https://medicine.duke.edu/profile/william-joseph-evans
Short Physical Performance Battery https://www.physio-pedia.com/Short_Physical_Performance_Battery
MyoCorp website https://myocorps.com/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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44% of supplements FAIL testing! Dr. Glenn, Head of Science at SuppCo, reveals which supplements don't contain what they say, how to spot red flags, and why even expensive brands might be lying about what's in the bottle. Learn the 3 essential rules before buying ANY supplement.
Think your supplements contain what they claim? Think again. Dr. Glenn, Head of Science at SuppCo, drops a bombshell: 44% of supplements they've tested have failed - meaning they contain less than 95% of the active ingredient listed on the label. Many have ZERO active ingredients at all.
In this eye-opening interview, Dr. Glenn exposes the dark side of the $70 billion supplement industry, including creatine gummies on Amazon with no creatine, urolithin A products with less than 1% of the active ingredient, and why products with better reviews often contain nothing at all.
Learn which certifications actually matter (NSF, USP, cGMP), the red flags to watch for when shopping, why gummies are particularly risky, and how SuppCo's trust score system helps consumers navigate the overwhelming world of supplements. Plus, get Dr. Glenn's 3 essential tips every supplement buyer needs to know before making their next purchase.
🌐Links in this video
SuppCo website : https://supp.co/home/today
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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Methylene blue was the first synthetic medicine ever created. 140 years later, we're discovering it might be one of the most powerful tools for brain health and longevity. Here's what the research actually shows.
Dr. Francisco Gonzalez-Lima has spent decades researching methylene blue, the first synthetic medicine in history. In this conversation, he explains how this unique compound enhances mitochondrial function, increases cellular energy production, and reduces oxidative stress; all at very low doses.
We discuss the critical importance of dose (low dose benefits, high dose harms), why pharmaceutical-grade purity matters, and how to personalize your dosing using a simple urine test. Dr. Gonzalez-Lima also addresses common misconceptions from failed Alzheimer's trials and explains why those studies used the wrong approach.
Looking ahead, he shares his plans to combine methylene blue with near-infrared light therapy and MCT oil for his upcoming clinical trial on mild cognitive impairment. Whether you're interested in cognitive enhancement, neuroprotection, or healthy aging, this is essential viewing.
🌐Links in this video
Dr Gonzalez-Lima's page https://liberalarts.utexas.edu/psychology/faculty/fg
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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Hearing loss isn't just about your ears—it's about your brain. Dr. Ben Thompson reveals how treating hearing loss can reduce cognitive decline by 48% and shares breakthrough protocols for tinnitus recovery that actually work.
Audiologist Dr. Ben Thompson explains the critical connection between hearing health and cognitive function, discussing the landmark ACHIEVE study that showed hearing treatment reduced cognitive decline by 48% in at-risk older adults.
Learn how the ear and brain work together, what causes age-related hearing loss, and why the cochlea's hair cells don't regenerate. Dr. Thompson covers the biggest threats to your hearing (hint: it's not just aging), how to protect yourself from noise damage, and the truth about tinnitus, including why most people are told there's nothing they can do when effective treatments exist.
Discover how modern hearing aid technology has evolved beyond bulky devices to sleek, smartphone-integrated systems that actively separate speech from background noise. Whether you're experiencing hearing changes yourself or have aging family members, this conversation offers practical insights on preserving both hearing and cognitive health for the long term.
🌐Links in this video
Treble Health web page: https://treblehealth.com/
Treble Health YouTube Channel https://www.youtube.com/@treblehealth
Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial
https://pubmed.ncbi.nlm.nih.gov/37478886/
The ACHIEVE study page https://www.achievestudy.org/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
NAD+ Anti-Aging Breakthrough: How This Molecule Could Reverse Aging and Treat Alzheimer's Disease | Clinical Trial Results from Leading Longevity Researcher Dr. Evandro Fang
Some links are affiliate links so we will earn a commission when they are used to purchase products.
Dr. Evandro Fang from the University of Oslo reveals groundbreaking research on NAD+ and its role in combating aging and neurodegenerative diseases. In this interview, Dr. Fang discusses his lab's pioneering work on mitophagy (mitochondrial cleanup) and how NAD+ precursors like NR and NMN have shown remarkable results in clinical trials for premature aging disorders. He shares dramatic case studies, including a 3-year-old Austrian boy who regained motor skills after NAD+ treatment, and explains the molecular mechanisms behind aging at the cellular level. The conversation covers his upcoming Phase 2 clinical trial using Urolithin A for Alzheimer's disease, the challenges of translating longevity research into approved therapies, and combination approaches involving exercise and caloric restriction. Dr. Fang provides practical insights into current NAD+ supplementation evidence while addressing safety concerns and optimal dosing strategies. This technical but accessible discussion offers valuable perspectives on the future of anti-aging medicine and therapeutic interventions for age-related diseases.
🌐Links in this video
Dr Fang's page https://evandrofanglab.com/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
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Could a simple supplement that bodybuilders use to build muscle actually help fight Alzheimer's disease? Dr. Matthew Taylor from the University of Kansas reveals surprising results from her groundbreaking clinical trial testing high-dose creatine in Alzheimer's patients
In this episode, Dr. Matthew Taylor discusses his pioneering research on creatine supplementation for Alzheimer's disease, addressing a critical gap in brain energy metabolism that worsens with aging and becomes severely impaired in dementia. His 8-week clinical trial gave 20 Alzheimer's patients 20 grams of creatine daily - a bodybuilder's loading dose - and found remarkable improvements in memory, executive function, and even unexpected gains in reading comprehension. Using advanced MRI spectroscopy, his team confirmed that creatine actually reaches the brain, increasing levels by 11%. Beyond cognitive benefits, participants also showed significant improvements in hand grip strength and muscle mass. Dr. Taylor explains how brain energy metabolism creates a vicious cycle in Alzheimer's, explores whether creatine could prevent dementia in healthy aging, and reveals his plans for combining creatine with ketogenic diet approaches. This conversation offers hope for a simple, accessible intervention that could help millions facing cognitive decline.
🌐Links in this video
Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition
https://pmc.ncbi.nlm.nih.gov/articles/PMC12089086/
Dr Taylor's website at Kansas University https://www.kumc.edu/mtaylor3.html
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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A potential functional cure for HIV could be just months away from human trials. Dr. Lanna reveals how her company Sentcell is using cellular rejuvenation to eliminate HIV reservoirs—and the surprising anti-aging benefits that come with it.
n this groundbreaking interview, Dr. Lanna, founder and CEO of Sentcell, explains how his team has developed a revolutionary approach to HIV treatment that could eliminate the need for lifelong antiretroviral therapy. Unlike traditional strategies that target the virus directly, Sentcell's method uses a molecule called DOS to rejuvenate CD4 T-cells, triggering them to naturally clear HIV DNA from their own genomes through a process that mimics elite controllers—rare individuals who can suppress HIV without medication. The treatment works by reactivating dormant cellular pathways that outcompete HIV's integration machinery, effectively reversing viral integration and clearing infected cells within days to weeks. Beyond HIV, Dr. Lanna discusses his team's discovery of "rivers of telomeres"—vesicle structures released by rejuvenated T-cells that can systemically rejuvenate other organs and extend lifespan by 12-17 months in animal studies. With Phase 1 human trials planned for 2026 at University College London, this research represents a potential paradigm shift from managing HIV as a chronic condition to achieving a functional cure.
🌐Links in this video
Sentcell website https://sentcell.life/
Dr Lanna on LinkedIn https://www.linkedin.com/in/professor-alessio-lanna-ph-d-687a1bb1/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
When someone's LDL cholesterol hits 574 mg/dL, doctors typically expect the worst. But what if everything we think we know about cholesterol and heart disease risk is incomplete?
In this episode, I sit down with researchers Nick Norwitz, Adrian Soto-Mota, and Dave Feldman to discuss their groundbreaking study on lean mass hyperresponders - a rare population who develop extremely high LDL cholesterol on ketogenic diets despite being lean, fit, and metabolically healthy. Their recent paper "Plaque Begets Plaque, ApoB Does Not" challenges conventional wisdom by showing that in this unique population, neither LDL cholesterol nor ApoB levels predicted plaque progression over one year of follow-up. Instead, existing plaque was the strongest predictor of future plaque growth. We explore the proposed lipid energy model that may explain why some people's cholesterol skyrockets on keto, discuss the limitations and implications of their findings, and examine what this means for personalized cardiovascular risk assessment. This conversation touches on fundamental questions about causality in medicine, the importance of studying outlier populations, and why a one-size-fits-all approach to cholesterol management may be missing crucial nuances.
🌐Links in this video
Longitudinal Data From the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not https://pubmed.ncbi.nlm.nih.gov/40192608/
Citizen Science Foundation https://citizensciencefoundation.org/
Nick's home page https://www.nicknorwitz.com/
On X
Nick Nowitz https://x.com/nicknorwitz
Dave Feldman https://x.com/realDaveFeldman
Adrian Soto-Mota https://x.com/AdrianSotoMota
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
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Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach.
Some links are affiliate links so we will earn a commission when they are used to purchase products.
In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. Dr. Robbins also shares insights into next-generation compounds his lab is developing and hints at positive clinical trial results coming soon.
🌐Links in this video
APERS & TRIALS
Fisetin at the ITP
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
https://pmc.ncbi.nlm.nih.gov/articles/PMC10828146/
Bone strength trial
Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans
https://clinicaltrials.gov/study/NCT04313634
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (SToMP-AD)
https://www.clinicaltrials.gov/study/NCT04685590
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00046-4/fulltext
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age
https://pmc.ncbi.nlm.nih.gov/articles/PMC9924942/
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https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
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DESCRIPTION
Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.
Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.
🌐Links in this video
Dr Jeffery's page at UCL https://profiles.ucl.ac.uk/7465-glen-jeffery
Links to the NASA Study and write up
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
https://www.cell.com/cell/fulltext/S0092-8674(20)31461-6
https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/
Some papers mentioned in the inteview
Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision
https://www.nature.com/articles/s41598-025-09785-3
Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression
https://www.nature.com/articles/s41598-025-89081-2
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AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Discover why muscle power—not just strength—is the key predictor of healthy aging and longevity. Exercise physiologist Dr. Stuart Phillips reveals groundbreaking research showing that older adults can safely engage in power training, challenging decades of conventional wisdom about senior fitness.
In this interview renowned exercise physiologist and gerontology expert Dr. Stuart Phillips from McMaster University shares cutting-edge insights into optimizing exercise and nutrition for healthy aging. Dr. Phillips, who has spent decades researching muscle physiology and aging, breaks down the science behind successful aging and reveals why most people are focusing on the wrong metrics.
🌐Links in this video
Twitter/X: @McKinProf
Instagram: @McKinProf
LinkedIn: Stuart Phillips, McMaster University
TikTok: @McKinProf
Dr Phillips page at McMaster https://experts.mcmaster.ca/display/phillis
Dr Phillips' course on Coursera https://www.coursera.org/learn/hacking-exercise-health
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
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Revolutionary brain health breakthrough: Light therapy helmet shows remarkable results for memory loss and cognitive enhancement. Real patient stories reveal dramatic improvements in speech, balance, and memory function using photobiomodulation technology.
n this comprehensive interview with Liam, co-founder of Neuronic, we explore the cutting-edge world of photobiomodulation therapy for brain health. Discover how their light therapy devices - resembling bike helmets with 300+ LEDs - are helping patients with Alzheimer's, stroke, concussion, and long COVID brain fog. Liam shares incredible patient testimonials, including families saying "I got my mother back" and "I got my dad back" after just weeks of treatment. We dive deep into the science behind 1070 nanometer light therapy, discuss ongoing clinical trials, the FDA approval process, and how this technology is being used in clinics worldwide. Whether you're dealing with cognitive decline, seeking peak performance, or interested in preventive brain health, this episode reveals how light therapy could be a game-changer for neurological wellness.
🌐Links in this video
https://www.neuronic.online/
Neuronic Devices $100 Discount Code MODERN100 https://tinyurl.com/bdhtm2th
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
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Discover why the standard B12 test might be missing your deficiency, and learn the better biomarkers that could reveal if brain fog, fatigue, and cognitive decline are actually nutrition-related rather than age-related.
In this deep dive with Dr. Martin Warren, Chief Scientific Officer at the Quadrum Institute and leading B12 researcher, we explore why vitamin B12 deficiency is far more common and complex than most people realize. Dr. Warren explains why standard B12 blood tests are unreliable (with only 50/50 accuracy for detecting deficiency), why the current deficiency cutoff of 148 picomolar may be too low, and how homocysteine and methylmalonic acid are better indicators of functional B12 status. He reveals that B12 deficiency can masquerade as normal aging—causing brain fog, fatigue, and cognitive decline—but is often reversible with proper treatment. The discussion covers why plant-based diets create deficiency risks, how absorption changes with age due to intrinsic factor decline, the connection between B12 and brain health (including white matter damage), and practical testing and supplementation strategies. Dr. Warren also makes a compelling case for revolutionizing healthcare through regular micronutrient monitoring rather than waiting for disease symptoms to appear.
🌐Links in this video
Quadram Institute. https://quadram.ac.uk/people/martin-warren/
Pernicious anemia society https://pernicious-anaemia-society.org/
Club 12 https://www.club-12.org/
Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults https://pubmed.ncbi.nlm.nih.gov/39927551/
Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO
AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw
https://www.choosemuse.com
All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
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