Ancient humans ate dirt-covered root vegetables and fermented foods loaded with bacterial fragments, and that constant low exposure could explain why modern hygiene is backfiring on our health. I had a great conversation with Dr. Steven Gundry about lipopolysaccharides, those inflammatory molecules from gram-negative bacteria that trigger massive immune reactions when injected, yet seem to calm the system when we eat tiny amounts from plants, spices, grains, and soil. He explains wh...

A sensitive stomach and endless antibiotics as a kid left Dr. Vincent Pedre with a wrecked gut he never understood until much later. Now, he helps thousands rebuild their guts to quiet inflammation, sharpen the mind, and live longer with real energy. In this episode, we unpack why leaky gut quietly drives most chronic issues today, how endotoxins from bad bacteria trigger weight gain and insulin resistance, and the surprising truth behind acid reflux that keeps millions on unnecessary meds....

In this flashback episode, Chris Burres sits down with Dave Asprey to break down metabolic health, insulin resistance, and what actually drives longevity. We’re revisiting this conversation because science still holds up, and matters more than ever. Dave explains how metabolic dysfunction can develop years before standard blood tests show problems, and why insulin is often the earliest and most overlooked warning sign. Chris and Dave also cover practical ways to improve metabolic flexibili...

Maximizing your healthspan requires understanding your specific genetic blueprint to see how your body processes fats, carbs, and antioxidants. Standard medical school training provides only a fraction of the education needed to understand nutrition and prevention. I sat down with Dr. Jeff Graham to uncover why common health "hacks" like Vitamin E or intermittent fasting might be backfiring based on your DNA. We explore the transition from high-intensity athletics to longevity-focused...

Your youngest, healthiest cells already exist, and they might be the key to repairing skin, hair, joints, immunity, and aging itself. Microplastics, pharmaceuticals, and chronic stress get a lot of attention in longevity, but almost no one talks about what happens when your body runs out of high-quality repair cells. I sat down with Dr. Drew Taylor to discuss why aging accelerates as stem cell reserves decline and how banking your best cells today could change how you heal decades fro...

Microplastics are now showing up inside human reproductive organs, while endocrine-disrupting chemicals quietly wreck hormonal health from every angle. The standard medical system often dismisses these environmental toxins as normal despite the massive impact on performance and longevity. Miguel Bertonatti was a shredded eighteen-year-old suffering from erectile dysfunction, while his brother Carlos was surviving on whiskey and sixty milligrams of Adderall just to function. They stopped acc...

A single 20-minute session in a wireless suit left my wife sore for six days and turned a fit CrossFitter into someone who suddenly felt the barbell was loaded wrong because he got dramatically stronger after just two workouts. Alec Oliver, the founder of SQAI, brought elite-athlete electrical muscle stimulation out of secret training rooms and million-dollar clinics and made it something you can own, control from your phone, and use while you watch TV. We go hard on the science of why EMS ...

That random itchy tingle under your skin, the brain fog that hits every afternoon, the tight calves and plantar fasciitis that won’t quit… turns out those aren’t “just aging.” They’re red flags your body waves when old infections are quietly camping out in your organs, speeding up the clock. In this episode, Dr. Motley drops twenty years of clinical stories (including the frequency machine that saved his dad from fainting spells) and shows exactly which hidden strep, herpes viruses, L...

Reading half a million brain scans taught Dr. Kavin Mistry one wild truth: some 80-year-olds have brains that look 40, while plenty of 50-year-olds already look 90. He cracked the code on why that happens and turned it into seven simple paradigms that don’t just slow aging; they actually rewind the clock on your cells. We unpack his Amazon #1 bestseller, Primal Health Design, the tribe in Africa that basically never gets chronic diseases, why every single fear (yes, even public speaking) tr...

Perimenopause, hormone balance, and real prevention are not soft topics; they are the difference between feeling like yourself or feeling lost in your own body. Dr. Jen Pfleghaar joined me to lay out what’s actually happening in midlife women, why so many are getting brushed off, and what can be done early enough to change the whole trajectory. Dr. Jen also talks about cycle syncing, progesterone support, estrogen metabolism, and the hidden stress patterns that quietly wreck sleep, mood, an...

In this episode, we revisit our insightful conversation with Ben Azadi, bestselling author and metabolism expert. Ben shares powerful insights on achieving metabolic freedom, breaking free from diet myths, and transforming your self-image to optimize your health and energy. What You’ll Learn in This Episode: How insulin resistance is a root cause of many chronic diseases and how to reverse itThe benefits of metabolic flexibility and how "flex days" can improve your healthPractical tips on r...

A potato-sized abscess nearly ended his life in 2023, yet three weeks after emergency brain surgery, Dr. Brandon Brown was back adjusting patients. Today, the Migraine Doc shares the upper cervical secret that’s quietly erasing chronic migraines for thousands who were told “it’s just a migraine” and sent home with pills. In this episode, Brandon walks us through the seizure that started it all, the moment his brain literally shrank back to normal the second the infection was removed, and e...

Imagine waking up paralyzed for 25 years and then walking into Thanksgiving dinner on your own two feet. That actually happened to one woman after working with Garret Salpeter and his Neufit technology, and it’s the kind of result that makes you rethink everything you know about healing. In this episode, Garret breaks down why your nervous system is the real bottleneck in recovery, performance, and even chronic pain. We talk about the Neufit Neubie, a direct-current device that bypasses the o...

We often separate kindness from science, but they are deeply connected at a cellular level. Mark Young reveals how the act of giving actually triggers physiological changes that clear cognition, reduce stress, and might be the key to your next breakthrough. In this episode, Mark explains the powerful childhood story that led to his book, Radical Generosity, and why solving someone else's problem is the ultimate hack for your own nervous system. We also get into the weeds of his comp...

Our microbiome isn’t just digesting food; it’s directing our mood, our focus, and even the way we age. Dr. Steven Gundry explains how lipopolysaccharides (LPS), lectins, and damaged gut walls quietly drive inflammation, brain fog, and autoimmune flare-ups, and how re-training your immune system through smarter food choices can reverse these effects. Dr. Gundry shares how a single patient changed his entire career from heart surgeon to health educator, why healing leaky gut is the real key t...

Stress, trauma, and inflammation don’t just affect your mind but also rewire your immune system. Justin Maguire explains how emotional wounds, environmental toxins, and hidden pathogens can keep your body stuck in a “cell danger response” that fuels chronic inflammation, autoimmunity, and fatigue. Justin’s journey from childhood trauma and addiction to discovering his autoimmune condition and building Autonomic Coaching shows what’s possible when science meets self-awareness. We explore how...

Chronic stress and hormone chaos don’t just steal your energy; they rewrite your biology. Dr. Anna Cabeca shares how balancing oxytocin, managing cortisol, and tracking your body’s pH can reset metabolism, mood, and even fertility. After losing her mother to heart disease and facing her own early menopause diagnosis, Dr. Anna transformed her life (and thousands of others) by blending science with ancient wisdom. Her story of reversing infertility, healing burnout, and discovering the power ...

Stress isn’t just in your head; your body keeps score. Justin Roethlingshoefer explains how heart rate variability (HRV) reveals whether your body feels safe enough to heal, and why understanding this single metric can unlock lasting energy, better sleep, and complete ownership of your health. After facing a life-threatening diagnosis and years of being told he was “fine,” Justin turned to data to find what every doctor missed. His journey from a teenage hockey player battling anorexia to c...

True energy starts at the cellular level. Barton Scott reveals how balancing minerals, mastering absorption, and using nanotechnology can restore focus, mood, and vitality far beyond what diet or supplements alone can do. A chemical engineer turned nutritionist, Barton founded Upgraded Formulas after losing his mother and realizing that supplements, diets, and testing were all failing to show real results. In this conversation, he shares how nanotechnology changed mineral absorption, why ha...

Longevity isn’t luck; it’s data, discipline, and daily tracking. Dr. Michael Lustgarten shows us what it really takes to measure, master, and extend human healthspan through science and self-experimentation. Dr. Lustgarten has spent two decades turning his body into a living lab. With over 35 published papers, a TED Talk on personalized health, and his book Microbial Burden, he’s on a mission to quantify everything from diet and biomarkers to blood chemistry and gut health. We discuss why...